Medical Genetics
FOXO1 is a tumor suppressor in cervical cancer
Authors: B. Zhang, L.S. Gui, X.L. Zhao, L.L. Zhu and Q.W. Li
Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in ce.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.3
- DOI:
- 10.4238/2015.June.18.3
Clinical features and treatment of endophthalmitis after cataract surgery
Authors: J. Zhu and Z.H. Li
The aim of this study was to investigate the clinical features and treatment results of endophthalmitis after cataract surgery. Five patients with endophthalmitis after phacoemulsification with intraocular lens implantation were enrolled in this study. The pathogenesis, clinical manifestation, and surgical outcomes of 5 patients were compared. Three patie.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.4
- DOI:
- 10.4238/2015.June.18.4
Nucleolar-persistence phenomenon during spermatogenesis in genus Meccus (Hemiptera, Triatominae)
Authors: F.F. Madeira, A.A.C. Lima, J.A. Rosa, M.T.V. Azeredo-Oliveira and K.C.C. Alevi
The Triatominae subfamily consists of 150 species in 18 genera, grouped into six tribes. In cytogenetics, triatomines are important biological models because they have holocentric chromosomes and nucleolar persistence in meiosis. The phenomenon of nucleolar persistence has been described for 23 species of triatomine in three g.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017427
- DOI:
- 10.4238/gmr.15017427
Association between IL-1�², IL-8, and IL-10 polymorphisms and risk of acute pancreatitis
Authors: D. Li, J. Li, L. Wang and Q. Zhang
We assessed the possible correlation between genetic polymorphisms in interleukin (IL)-1β, IL-8, and IL-10 and risk of acute pancreatitis. Polymorphisms of IL-1β +3954C/T (rs1143634), IL-1β -511C/T (rs16944), IL-8 -251T/A (rs4073), IL-10 -1082A/G (rs1800896), and IL-10 -819C/T (rs1800871) were assessed by polymerase chain reaction-restricti.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.6
- DOI:
- 10.4238/2015.June.18.6
Effect of morphine preconditioning in the delayed phase on the expression of p38 mitogen-activated protein kinase in a rabbit model of myocardial ischemia-reperfusion injury
Authors: K. Ran, Z.X. Gong, D.L. Yang, Y.T. Chang, K.M. Duan and Y.W. Ou
This study aimed to investigate the protective effects of delayed morphine preconditioning on myocardial ischemia-reperfusion injury. We randomly divided 30 rabbits into three groups with 10 rabbits in each group as follows: sham operation group (C group), ischemia-reperfusion group (I/R group), and morphine pretreatment group (M group). Rabbits in C Grou.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.7
- DOI:
- 10.4238/2015.June.18.7
Population structure and demographic history of Sicyopterus japonicus (Perciformes; Gobiidae) in Taiwan inferred from mitochondrial control region sequences
Authors: Y.M. Ju, C.H. Hsu, L.S. Fang, H.D. Lin, J.H. Wu, C.C. Han, I.-S. Chen and T.Y. Chiang
The amphidromous goby Sicyopterus japonicus is distributed throughout southern Taiwan and Japan. Larvae of this freshwater fish go through a long marine stage. This migratory mode influences population genetic structure. We examined the genetic diversity, population differentiation, and demographic history of S. japonicus based on the mitochondrial DNA co.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.6
- DOI:
- 10.4238/2013.September.27.6
Unicentric Castleman disease located in the anterior mediastinum misdiagnosed as invasive thymoma: a case report
Authors: Y. Liu, D.Y. Xie, X.M. Lin and C. Chi
Castleman disease is a rare lymphoproliferative disorder of unknown etiology. The localized form, which usually presents as a slow-growing mass, is most commonly located in the mediastinum. Invasion of the vena anonyma by a mass has rarely been reported. We herein describe a case of initially misdiagnosed invasive thymoma in a 72-year-old woman, but posto.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.10
- DOI:
- 10.4238/2015.June.18.10
Chemical signatures in the developmental stages of Protopolybia exigua
Authors: E.R.S. Silva, K.B. Michelutti, W.F. Antonialli-Junior, M. Batistote and C.A.L. Cardoso
The chemical signature of social insects is very important for communication, and specific signs of each colony and its individuals are acquired throughout their development. This chemical signature can also be related to the composition of the materials employed during nest construction. Furthermore, the venom also contains i.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017586
- DOI:
- 10.4238/gmr.15017586
Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis
Authors: Q.F. Li, Q.Y. Li, A.R. Gao and Q.F. Shi
Epigenetic silencing of the GSTP1 gene by promoter methylation has been associated with increased risk and shortened survival in patients with hepatocellular carcinoma (HCC). We therefore conducted a meta-analysis to obtain a more precise estimate of this association. By searching the Cochrane Library, CBM, EMBASE, PubMed, and the Web of Science, we tabul.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.19
- DOI:
- 10.4238/2015.June.18.19
MicroRNA analysis in model species based on evolutionary rates
Authors: X.F. Mao and Y.C. Cao
MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression. In an attempt to gain insights into miRNAs at the macroevolutionary level, we performed a systematic analysis of miRNAs in six model organisms based on their evolutionary rates. First, we calculated their miRNA evolutionary rates, and found that they did not correlate with th.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017216
- DOI:
- 10.4238/gmr.15017216