Medical Genetics
Clinical and pathological features and treatment of AIDS-related cutaneous Kaposi�s sarcoma in Chinese Han patients
Authors: X.-K. Zheng, S.-H. Lu, J.-F. Liu and Y.-R. Lai
This retrospective study aimed to observe the clinicopathological features and immunological phenotypes, and explore effective treatment and prognosis for 12 Chinese Han patients with acquired immunodeficiency syndrome-related cutaneous Kaposi’s sarcoma. All 12 patients were human immunodeficiency virus-positive, and underwent the standard highly ac.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.25
- DOI:
- 10.4238/2015.June.18.25
Expression and significance of S100P, CD147, and OCT4 in different prostate cancer tissue TNM stages
Authors: Q. Wang, J.G. Zhang and W. Wang
The aim of this project was to investigate the expression and significance of S100P, CD147, and OCT4 in prostate cancer tissue at different TNM stages. We enrolled 54 patients with prostate cancer, 40 with benign prostatic hyperplasia, and 20 subjects with normal prostates. S100P, CD147, and OCT4 were detected by immunohistochemistry. The positive rate of.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.27
- DOI:
- 10.4238/2015.June.18.27
Development and characterization of novel microsatellite markers for Ginkgo biloba using 454 pyrosequencing
Authors: Q. Zhou, X.X. Wang, M. Xu, F.L. Cao, F.X. Yu and L.A. Xu
As a “living fossil” that is used to understand the evolutionary history of seed plants, Ginkgo biloba is a well-known multipurpose tree with edible seeds, medicinal properties, and ornamental value, but little is known about its genetic diversity. Microsatellite, or simple sequence repeat (SSR), markers have prove.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017385
- DOI:
- 10.4238/gmr.15017385
Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon
Authors: S.M. Ghogomu, N.E. Ngolle, R.N. Mouliom and B.F. Asa
The association of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and essential hypertension has been reported but with controversial results in diverse populations in Asia and Europe, thereby suggesting a dependency on ethnicity. The aim of this study was to investigate the association between the MTHFR C677T polymorphism and ess.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017462
- DOI:
- 10.4238/gmr.15017462
High levels of polymorphism found through cross-amplification of microsatellite loci in a Ctenomys pearsoni (Rodentia, Ctenomyidae) population
Authors: N. Mannise, S. Gonz�¡lez, J.E. Maldonado, G. Izquierdo, G. Francescoli and M. Cosse
Ctenomys pearsoni (Pearson’s tuco-tuco) is a subterranean rodent native to Uruguay. We tested the amplification pattern of 12 microsatellite loci, designed for C. sociabilis and C. haigi in a C. pearsoni population. DNA extractions were made from hair samples, and PCR amplification products were run on an ABI 3100 microcapillary gel. Eight loci were.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.5
- DOI:
- 10.4238/2013.April.2.5
Gene expression study related with the intrinsic pathway of apoptosis in bladder cancer by real-time PCR technique
Authors: D.F. Barione, F.S.N. Lizarte, P.C. Novais, C.A.M. de Carvalho, F.C.B. Valeri, F.M. Peria, H.F. de Oliveira, D.L. Zanette, W.A. Silva Jr., A.J. Cologna, R.B. Reis, S. Tucci Jr., A.C.P. Martins, D.P.C. Tirapelli and L.F. Tirapelli
We examined the expression of anti-apoptotic genes (XIAP and Bcl-2) and apoptotic genes (cytochrome c, caspase-9, Apaf-1) in tissue samples of patients with superficial bladder cancer. Thirty-two bladder cancer tissue samples (8 papillary urothelial neoplasm of low malignant potential, 10 low-grade, and 14 high-grade) and 8 normal bladder tissue samples f.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.4
- DOI:
- 10.4238/2013.April.2.4
Association between a point mutation at the -743-bp region of the transthyretin (TTR) gene and familial vitreous amyloidosis
Authors: X.M. Nie, S.J. Cai, B. Xie, X.W. Chen and M. Jiang
The aim of this study was to identify changes in the base sequence of the upstream regulatory region of the transthyretin (TTR) gene. Whole-blood DNA was extracted from ten subjects belonging to a family with familial amyloidosis vitreoretinopathy; the upstream regulatory sequence was amplified by polymerase chain reaction, detected by gel electrophoresis.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016926
- DOI:
- 10.4238/gmr.15016926
Intracranial aneurysm risk factor genes:relationship with intracranial aneurysm risk in a Chinese Han population
Authors: L.T. Zhang, F.J. Wei, Y. Zhao, Z. Zhang, W.T. Dong, Z.N. Jin, F. Gao, N.N. Gao, X.W. Cai, N.X. Li, W. Wei, F.S. Xiao, S.Y. Yue, J.N. Zhang, S.Y. Yang, W.D. Li and X.Y. Yang
Few studies have examined the genes related to risk factors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression mod.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.30
- DOI:
- 10.4238/2015.June.18.30
Forced expression of OCT4 influences the expression of pluripotent genes in human mesenchymal stem cells and fibroblasts
Authors: C.S. Palma, M.A. Tannous, T.M. Malta, E.M.S. Russo, D.T. Covas and V. Pican�§o-Castro
Genetic reprogramming of adult cells to generate induced pluripotent stem (iPS) cells is a new and important step in sidestepping some of the ethical issues and risks involved in the use of embryonic stem cells. iPS cells can be generated by introduction of transcription factors, such as OCT4, SOX2, KLF4, and CMYC. iPS cells resemble embryonic stem cells .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.22
- DOI:
- 10.4238/2013.April.2.22
Association between the rs4753426 polymorphism in MTNR1B with fasting plasma glucose level and pancreatic �²-cell function in gestational diabetes mellitus
Authors: Y. Zhan, C. Li, Q. Gao, J. Chen, S. Yu and S.G. Liu
We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were de.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.1
- DOI:
- 10.4238/2015.August.3.1