Medical Genetics
Development of a new amplification-refractory mutation system for detection of a single nucleotide polymorphism linked to drug resistance in Ancylostoma caninum
Authors: L.F. Furtado and Ã?Â?.M. Rabelo
Single nucleotide polymorphisms at codons 167, 198, and 200 in the β-tubulin isotype 1 gene have been associated with benzimidazole resistance. Until now, the only mutation observed in Ancylostoma caninum was at codon 200 of this gene. However, the standardized methodologies used to detect mutations in this species are faulty. The objective of this s.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.12.13
- DOI:
- 10.4238/2015.May.12.13
A repetitive sequence assembler based on next-generation sequencing
Authors: S. Lian, Y. Tu, Y. Wang, X. Chen and L. Wang
Repetitive sequences of variable length are common in almost all eukaryotic genomes, and most of them are presumed to have important biomedical functions and can cause genomic instability. Next-generation sequencing (NGS) technologies provide the possibility of identifying capturing these repetitive sequences directly from the NGS data. In this study, we .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038790
- DOI:
- 10.4238/gmr.15038790
Association of CHRNA4 gene rs1044396 and rs1044397 polymorphisms with Parkinson�s disease symptoms and smoking
Authors: L.M. Zhang, X.P. Zhang, Y.Q. Chen and W. Ye
We assessed the CHRNA4 exon 5 rs1044396 and rs1044397 polymorphisms and investigated their relationship with Parkinson’s disease (PD) severity and several non-motor symptoms. Ninety-seven patients with primary PD and 108 controls were recruited, and their smoking history identified. Patients with PD were assessed using the unified PD rating scale (U.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.12.14
- DOI:
- 10.4238/2015.May.12.14
Protein-protein interaction network construction for cancer using a new L1/2-penalized Net-SVM model
Authors: H. Chai, H.H. Huang, H.K. Jiang, Y. Liang and L.Y. Xia
Identifying biomarker genes and characterizing interaction pathways with high-dimensional and low-sample size microarray data is a major challenge in computational biology. In this field, the construction of protein-protein interaction (PPI) networks using disease-related selected genes has garnered much attention. Support vector machines (SVMs) are commo.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038794
- DOI:
- 10.4238/gmr.15038794
IFGFA: Identification of featured genes from genomic data using factor analysis
Authors: C.H. Fu, S. Deng, J.H. Wu, X.Q. Wu, Z.H. Fu and Z.G. Yu
In this study, a software tool (IFGFA) for identification of featured genes from gene expression data based on latent factor analysis was developed. Despite the availability of computational methods and statistical models appropriate for analyzing special genomic data, IFGFA provides a platform for predicting colon cancer-related genes and can be applied .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038803
- DOI:
- 10.4238/gmr.15038803
Effects of the Zhikang capsule on healing of the flap after radical breast cancer surgery
Authors: C. Cheng, Y. Lv, E. Zhang, T. Yan, C. Li, D.-X. Hou and J.-H. Li
This study aimed to investigate the effect and mechanism of trauma flap healing promoted by the Zhikang capsule after radical breast cancer surgery. The enrolled breast cancer patients were randomly divided into two groups: treatment and observation. The patients in the treatment group were treated with the Zhikang capsule in addition to the conventional .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.2
- DOI:
- 10.4238/2015.May.18.2
Meta-analysis of differentially expressed genes in ankylosing spondylitis
Authors: Y.H. Lee and G.G. Song
The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in ankylosing spondylitis (AS). We performed a metaanalysis using the integrative meta-analysis of expression data program on publicly available microarray AS Gene Expression Omnibus (GEO) datasets. We performed.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.6
- DOI:
- 10.4238/2015.May.18.6
Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis
Authors: Y. Zhao,H.R. He, M.Y. Wang, X.D. Ren, L. Zhang, Y.L. Dongand J. Lu
Cyclin D1 (CCND1) is a key protein involved in cellcycle regulation, and the CCND1 G870A polymorphism is associated with many types of malignancy. Studies examining the associations between this G870A polymorphism and susceptibility to leukemia and hepatocellular carcinoma (HCC) have shown inconsistent results. Therefore, we conducted a meta-analysis to c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.7
- DOI:
- 10.4238/2015.May.18.7
Catheter-directed thrombolysis in the treatment of acute deep venous thrombosis: a meta-analysis
Authors: J.J. Zheng, Z.H. Zhang, Z. Shan, W.J. Wang, X.X. Li, S.M. Wang, Y.-X. Li and G.-S. Cheng
We performed a meta-analysis for systematic evaluation of the status quo of catheter thrombolysis for the treatment of acute lower limb deep vein thrombosis in China. We searched the China Biomedical bibliographic database (CBM), China National Knowledge Infrastructure (CNKI), Weipu full-text electronic journals, Wanfang full-.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.1
- DOI:
- 10.4238/2014.July.24.1
Effects of changes in serum endostatin and fibroblast growth factor 19 on the chemotherapeutic sensitivity in acute myeloid leukemia patients
Authors: Y.Z. Su, C.B. Wang, Y. Zhou and N.T. Sun
The present study aimed to explore the changes in serum endostatin and fibroblast growth factor 19 (FGF-19) in acute myeloid leukemia patients, and to determine their effects on chemotherapeutic sensitivity. Sixty acute myeloid leukemia patients and 30 healthy controls were included in the study. Patient serum endostatin and FGF-19 levels were measured on.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.8
- DOI:
- 10.4238/2015.May.18.8