Medical Genetics
Meta-analysis demonstrates no association between p53 codon 72 polymorphism and prostate cancer risk
Authors: M.S. Li, J.L. Liu, Y. Wu, P. Wang and H. Teng
We examined whether p53 codon 72 polymorphism confers prostate cancer risk by conducting a meta-analysis. Two investigators independently searched the Pubmed, Embase and CBM databases. This meta-analysis was made of seven case-control studies, that included 892 prostate cancer cases and 1020 healthy controls. Meta-analysis res.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.29.3
- DOI:
- 10.4238/2011.November.29.3
Comparative RNA profile analysis of idiopathic dilated cardiomyopathy and ischemic cardiomyopathy
Authors: L.L. Qiu, X.J. Ding, H.T. Zhu, L.W. Gao, J.F. Tang and X.Q. Liu
Previous research has focused on revealing the functions of each individual gene and/or pathway in idiopathic dilated cardiomyopathy (DCM) or ischemic cardiomyopathy (IC). However, the common or specific pathways of the initiation and processes of DCM and IC are still unclear. Here, we attempted to uncover the critical genes and potential molecular networ.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016910
- DOI:
- 10.4238/gmr.15016910
A diagnostic kit for the enteroviruses Coxsackie A6 and A10
Authors: X.Y. Zhang1, X. Yao2, Z.W. Chen3, X.H. Jiang4, N.H. Xie3, C.Y. Zhang5 and Z.H. Guan5
Recently, there has been an upward trend in the occurrence of hand-foot-mouth disease, which is correlated with Coxsackie A6 and A10 infections. Although two separate diagnostic reagents are available for these two viral strains, the protocol and diagnosis efficiency still need to be improved. More importantly, as co-infection with these viruses is common.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017431
- DOI:
- 10.4238/gmr.15017431
Mangiferin induces cell cycle arrest at G2/M phase through ATR-Chk1 pathway in HL-60 leukemia cells
Authors: Z.G. Peng, Y.B. Yao, J. Yang, Y.L. Tang and X. Huang
This study aimed to determine the effect of mangiferin on the cell cycle in HL-60 leukemia cells and expression of the cell cycle-regulatory genes Wee1, Chk1 and CDC25C and to further investigate the molecular mechanisms of the antileukemic action of mangiferin. The inhibitory effect of mangiferin on HL-60 leukemia cell proliferation was determined by the.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.12.2
- DOI:
- 10.4238/2015.May.12.2
Lack of association between the ESR1 rs9340799 polymorphism and age at menarche: a meta-analysis
Authors: H.Y. Wu, X.K. Xing, K.J. Wang and L. Zhang
It has been reported that the estrogen receptor alpha (ESR1) rs9340799 polymorphism is associated with age at menarche (AAM). However, recent investigations have generated inconsistent results. This study aimed to establish a more precise estimation of the association between this polymorphism and AAM. A meta-analysis was conducted based on an in silico l.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038598
- DOI:
- 10.4238/gmr.15038598
PI3K-Akt-mTOR signal inhibition affects expression of genes related to endoplasmic reticulum stress
Authors: Q. Song, C.C. Han, X.P. Xiong, F. He, W. Gan, S.H. Wei, H.H. Liu, L. Li and H.Y. Xu
PI3K-Akt-mTOR signaling pathway is associated with endoplasmic reticulum (ER) stress. However, it is not clear how this signaling pathway affects the ER stress. The present study aimed to determine whether the PI3K-Akt-mTOR signaling pathway regulates tunicamycin (TM)-induced increases in mRNA levels of genes involved in the ER stress, to help elucidate t.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037868
- DOI:
- 10.4238/gmr.15037868
Association between the WRAP53 gene rs2287499 C>G polymorphism and cancer risk: A meta-analysis
Authors: H.Y. Cao, S. Wang, Z.Y. Zhang and J.Y. Lou
The TP53 5'-untranslated region flanking the gene WRAP53 (also known as WDR79 and TCAB1) has been hypothesized to be associated with cancer risk due to its critical function in regulating p53 levels. In this review, we analyzed the association between the WRAP53 gene rs2287499 C>G polymorphism and risk of cancer using five case-control studies, compris.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037976
- DOI:
- 10.4238/gmr.15037976
Expression of PAPPA2 in human fetomaternal interface and involvement in trophoblast invasion and migration
Authors: H.Y. Wang, Z. Zhang and S. Yu
Pregnancy-associated plasma protein-A 2 (PAPPA2) is a placental-enriched gene that is important for normal human placentation and defects in the gene can cause complications in pregnancy. Yet the exact expression pattern and role of PAPPA2 in the human fetomaternal interface are not clear. In this study, in situ hybridization (ISH) and immunohistochemistr.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038075
- DOI:
- 10.4238/gmr.15038075
A novel rare copy number variant of the ABCF1 gene identified among dengue fever patients from Peninsular Malaysia
Authors: B.P. Hoh1, S.S. Sam2, S.H. Umi1, M. Mahiran3, N.Y. Nik Khairudin4, S. Rafidah Hanim5 and S. AbuBakar2,6
Copy number variation (CNV) is a form of genetic variation in addition to single nucleotide polymorphisms. The significance of CNV in the manifestation of a number of diseases is only recently receiving considerable attention. We genotyped 163 dengue patients from Peninsular Malaysia for genes possibly linked to dengue infecti.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.19.9
- DOI:
- 10.4238/2014.February.19.9
BRAF overexpression is associated with BRAF V600E mutation in papillary thyroid carcinomas
Authors: R.C. da Silva, H.S.C. de Paula, C.B.Q.S. Leal, B.C.R. Cunha,E.C. de Paula, R.C.G. Alencar, A.J. Meneghini, A.M.T.C. Silva,A.P. Gontijo, I.J. Wastowski and V.A. Saddi
A common mutation in the BRAF gene, comprising the T1799A nucleotide transversion, which leads to the V600E amino acid substitution in the BRAF protein, has been observed in about 50% of papillary thyroid carcinomas (PTCs). However, BRAF protein expression has been rarely examined in such tumors. Clinical studies have shown important associations between .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.12.9
- DOI:
- 10.4238/2015.May.12.9