Medical Genetics
HydroCalc Proteome: a tool to identify distinct characteristics of effector proteins
Authors: G.J. da Silva, R.G.T.M. da Silva, V.A. Silva, E. C. Carit�¡, A.L. Fachin and M. Marins
Bacterial pathogenicity is associated with secretion of effector proteins into intra- and extracellular spaces. These proteins interfere with cellular processes such as inhibition of phagosome-lysosome fusion, induction of apoptosis and autophagy, activation and suppression of kinases, regulation of receptor activity, and modulation of transcription facto.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038111
- DOI:
- 10.4238/gmr.15038111
Predictive role of RRM1 and BRCA1 mRNA expression on the clinical outcome of advanced non-small cell lung cancer
Authors: J.G. Liang, Z.Y. Jin, X.D. Gao, M.R. Te, L.H. Ge and C.L. Wang
This study aimed to evaluate the association between RRM1 and BRCA1 expressions and the therapeutic efficacy of platinum-based chemotherapy in non-small cell lung cancer patients in terms of their response and prognosis. In total, 377 patients agreed to participate in our study, and all of them received plati.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.8
- DOI:
- 10.4238/2014.July.24.8
Association of the TNF-�± +489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.12
- DOI:
- 10.4238/2015.May.18.12
Relationship between RFC gene expression and intracellular drug concentration in methotrexate-resistant osteosarcoma cells
Authors: J.J. Wang and G.J. Li
Osteosarcoma is a primary malignant tumor in adolescents, associated with high mortality and morbidity. The high-dose methotrexate (MTX) chemotherapy used to treat this disease may induce primary or secondary drug resistance, resulting in a reduced effect of comprehensive treatment. In this study, the relationship between redu.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.10
- DOI:
- 10.4238/2014.July.24.10
Limited open reduction is better for simple- distal tibial shaft fractures than minimally invasive plate osteosynthesis
Authors: Q. Li, B.F. Zeng, C.F. Luo, S. Song, C.Q. Zhang and W.Q. Kong
The aim of this study was to compare the effects and indications of minimally invasive plate osteosynthesis (MIPO) and limited open reduction (LOR) for managing distal tibial shaft fractures. A total of 79 cases of distal tibial shaft fractures were treated surgically in our trauma center. The 79 fracture cases were classified.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.15
- DOI:
- 10.4238/2014.July.24.15
A novel NF1 frame-shift mutation (c.702_703delGT) in a Chinese family with neurofibromatosis type 1
Authors: S.P. Cai, N. Fan, J. Chen, Z.L. Xia, Y. Wang, X.M. Zhou, Y. Yin, T.L. Wen, Q.J. Xia, X.Y. Liu and H.Y. Wang
This study aimed to characterize the clinical features of a Chinese pedigree with neurofibromatosis type 1 (NF1) and to identify mutations in the NF1 gene. In this three-generation family containing 8 members, 5 had been diagnosed with NF1 and the others were asymptomatic. All members of the family underwent complete medical e.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.19
- DOI:
- 10.4238/2014.July.24.19
Double-loop locking cross-stitch suture and suspension fixation for medial collateral ligament origin reconstruction
Authors: C.J. Li, B.C. Wang and D.Q. Liu
The purpose of this study was to summarize the clinical application and results of the double-loop locking cross-stitch suture and suspension fixation method for medial collateral ligament origin reconstruction. Thirty-six patients (21 males, 15 females) with an average age of 40 years (range = 17-58 years), who underwent trea.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.20
- DOI:
- 10.4238/2014.July.24.20
Genetic diversity of Toona sinensis Roem in China revealed by ISSR and SRAP markers
Authors: P.Y. Xing, T. Liu, Z.Q. Song and X.F. Li
Toona sinensis Roem has an important value as a type of traditional vegetable and Chinese medicinal herb, and is also a valuable source of wood in China. In this study, we used the inter-simple sequence repeat (ISSR) and sequence-related amplified polymorphism (SRAP) markers to assess the level and pattern of genetic diversity in five domesticated T. sine.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038387
- DOI:
- 10.4238/gmr.15038387
Functional polymorphisms in microRNAs and susceptibility to liver cancer: a meta-analysis and meta-regression
Authors: B.S. Wang, Z. Liu, W.X. Xu and S.L. Sun
MicroRNAs (miRNAs) are small non-coding RNA molecules that play a fundamental role in controlling a variety of biological functions. Emerging evidence has shown that common genetic polymorphisms in miRNAs may be associated with the development of liver cancer; however, several individually published studies showed inconclusive.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.22
- DOI:
- 10.4238/2014.July.24.22
Development of microsatellite markers of vandaceous orchids for species and variety identification
Authors: S. Peyachoknagul, C. Nettuwakul, P. Phuekvilai, S. Wannapinpong and K. Srikulnath
Vandaceous orchids are a group of orchid genera in the subfamily Vandoideae. Among this group, Mokara, Phalaenopsis, and Vanda are the most popular and commercially important orchids in Thailand. Novel microsatellite markers were developed from Mokara, the intergeneric hybrid from 3 genera Vanda.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.23
- DOI:
- 10.4238/2014.July.24.23