Medical Genetics
VKORC1 rs2359612 and rs9923231 polymorphisms correlate with high risks of cardiovascular and cerebrovascular diseases
Authors: Y. Li, J. Zhu and J.Q. Ding
We aimed to confirm the correlations between rs2359612 and rs9923231 single nucleotide polymorphisms (SNPs) in the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene and the risk of cardiovascular and cerebrovascular diseases (CCVDs) using meta-analysis. Electronic databases were exhaustively searched for rel.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.38
- DOI:
- 10.4238/2015.November.18.38
Serum levels of S-100�² correlate with the clinical status and severity of hypoxic-ischemic encephalopathy in neonates
Authors: L.H. Shi, Y. Zhou, M.F. Guo, J.S. Liu, C.X. Li, G.F. Wang, W. Liu and L. Tian
The clinical significance of serum S-100β levels in neonates with hypoxic-ischemic encephalopathy (HIE), as a reference index to assess HIE severity, was evaluated in this study. On the basis of our strict inclusion and exclusion criteria, relevant high-quality case-control studies reporting the association between HIE an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.41
- DOI:
- 10.4238/2015.November.18.41
Biological changes of Enterococcus faecalis in the viable but nonculturable state
Authors: J. E, Y.T. Jiang, P.F. Yan and J.P. Liang
Enterococcus faecalis may enter a viable but nonculturable (VBNC) state under adverse conditions. E. faecalis, the major bacterial species present in failed root canal treatments, is thought to survive after endodontic treatment by entering a VBNC state. In this study, we characterized the VBNC state of E.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.44
- DOI:
- 10.4238/2015.November.18.44
Technological value of SPECT/CT fusion imaging for the diagnosis of lower gastrointestinal bleeding
Authors: Z.G. Wang, G.X. Zhang, S.H. Hao, W.W. Zhang, T. Zhang, Z.P. Zhang and R.X. Wu
The aim of this study was to assess the clinical value of diagnosing and locating lower gastrointestinal (GI) bleeding using single photon emission computed tomography (SPECT)/computed tomography (CT) fusion imaging with 99mTc labeled red blood cells (99mTc-RBC). Fifty-six patients with suspected lower GI bleeding r.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.2
- DOI:
- 10.4238/2015.November.24.2
Multidrug resistance gene (MDR1) polymorphisms may not be directly associated with response to imatinib in chronic myeloid leukemia
Authors: J.L. Wang, H.J. Liu, F. Li, W.Y. Yang, J.M. Wang, S.F. Tan and Q. Wang
Our study aimed to investigate the association between multidrug resistance (MDR1) gene polymorphisms and the response to imatinib (IM) in chronic myeloid leukemia (CML). An electronic databases in PubMed, Cochrane Library, Wanfang, China National Knowledge Infrastructure, and VIP were searched using combinations of k.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.4
- DOI:
- 10.4238/2015.November.24.4
Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma
Authors: B.A. Coelho, G.T. Peterle, M. Santos, L.P. Agostini, L.L. Maia, E. Stur, C.V.M. Silva, S.O. Mendes, C.C.J. Alman�§a, F.V. Freitas, A.R. Bor�§oi, A.B. Archanjo, A.M.C. Mercante, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A Silva-Conforti
Five-year survival rates for oral squamous cell carcinoma (OSCC) are 30% and the mortality rate is 50%. Immunohistochemistry panels are used to evaluate proliferation, vascularization, apoptosis, HPV infection, and keratin expression, which are important markers of malignant progression. Keratins are a family of intermediate f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.21
- DOI:
- 10.4238/2015.November.24.21
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
Authors: P.R.S. Rodrigues, L.L. Maia, M. Santos, G.T. Peterle, L.U. Alves, J.T. Takamori, R.P. Souza, W.M. Barbosa, A.M.C. Mercante, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A. Silva-Conforti
The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been repo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.5
- DOI:
- 10.4238/2015.November.24.5
Suitable internal control microRNA genes for measuring miRNA abundance in pig milk during different lactation periods
Authors: Y.R. Gu, Y. Liang, J.J. Gong, K. Zeng, Z.Q. Li, Y.F. Lei, Z.P. He and X.B. Lv
Determination of an optimal set/number of internal control microRNA (miRNA) genes is a critical, but often undervalued, detail of quantitative gene expression analysis. No validated internal genes for miRNA quantitative PCR (q-PCR) in pig milk were available. We compared the expression stability of six porcine internal control miRNA genes in pig milk from.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.18.3
- DOI:
- 10.4238/2012.June.18.3
Structure and polymorphism of novel X-chromosome short tandem repeat loci in a Chinese Han population
Authors: Y.S. Zhu, H. Wu and J.H. Lai
Recently, 5 novel X-chromosome short tandem repeat (X-STR) loci with high degrees of polymorphism were examined. In this study, we investigated the genetic distribution of these loci in a Chinese Han population. The 5 X-STR loci were successfully examined by polyacrylamide gel electrophoresis in a total of 200 unrelated Shaanx.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.12
- DOI:
- 10.4238/2015.November.24.12
Effects of kinase insert domain receptor (KDR) gene silencing on the sensitivity of A549 cells to erlotinib
Authors: W.L. Zhu and Y.H. Liu
We investigated the effects of kinase insert domain receptor (KDR) gene silencing on the proliferation of A549 cells and their sensitivity to erlotinib. A KDR small interfering RNA (siRNA) sequence was designed and synthesized; then, it was transfected into A549 cells using LipofectamineTM 2000. KDR mRNA and protein expression after KDR gene si.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.15
- DOI:
- 10.4238/2015.November.24.15