Human Genetics
Effect of inhibition of MEK pathway on 5-aza-deoxycytidine-suppressed pancreatic cancer cell proliferation
Authors: X. Wang1, H. Wang1, N. Jiang1, W. Lu1, X.F. Zhang1 and J.Y. Fang2
Pancreatic adenocarcinoma is a lethal disease because it is inoperable at the time of diagnosis. Therefore, the search for new therapeutic approaches is critical. The abnormal expression of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) pathway and alteration in epigenetic modification (DNA methylation and acetylation of .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.6
- DOI:
- 10.4238/2013.November.18.6
Protective effects of the antileishmanial extract of Tephrosia cinerea (L.) Pers. (Fabaceae) against cyclophosphamide-induced damage
Authors: A.C.S. Dias1, V.R. Moreira1, L.P. Almeida1, M.I.S. Lima1, J.L. Bezerra2, M.N.S. Ribeiro2, F.R.F. Nascimento3 and S.R.F. Pereira1
Tephrosia cinerea L. (Pers.) is a tropical species that exhibits antileishmanial activity in Leishmania amazonensis promastigote cultures and is commonly used to treat infections, inflammations, ulcers, nervous conditions, and diarrhea. However, no studies have investigated its effects on genetic material. Therefore, we evaluated the genotoxic potential, .. Read More»
- Genet. Mol. Res. 13(4):
Lack of genotoxicity in Astyanax bimaculatus and Oreochromis niloticus of 17�±-methyltestosterone used in fish hatcheries to produce male monosex populations
Authors: C.L.G. Rivero-Wendt1, A.L. Miranda-Vilela1, M.F.N. Ferreira1, F.S. Amorim2, V.A.G. da Silva2, H. Louvandini3 and C.K. Grisolia1
17α-Methyltestosterone (MT) is widely used in fish hatcheries of many countries to produce male monosex populations. Its genotoxic risk to fish species is not well known and studies in other in vivo models are still inconclusive. MT was tested for genotoxicity in the fish species Oreochromis niloticus (tilapia), a target species, and Astyanax bimacu.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.13
- DOI:
- 10.4238/2013.October.24.13
Registries of cleft lip/palate cases between 2004 and 2010 in Denizli, Turkey
Authors: A.G. Tomat�±r, I. Acikbas, B. Akdag and A. K�¶ksal
Oral clefts are one of the most common birth defects in humans. However, few population-based studies of these defects have been carried out in Turkey. Our objective was to determine the registries of cases of cleft lip and palate. All cases of cleft lip and palate referred to central state hospitals in Denizli between January 2000 and May 2010 were inves.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.19.4
- DOI:
- 10.4238/2013.February.19.4
ReSeqTools: an integrated toolkit for large-scale next-generation sequencing based resequencing analysis
Authors: W. He, S. Zhao, X. Liu, S. Dong, J. Lv, D. Liu, J. Wang and Z. Meng
Large-scale next-generation sequencing (NGS)-based resequencing detects sequence variations, constructs evolutionary histories, and identifies phenotype-related genotypes. However, NGS-based resequencing studies generate extraordinarily large amounts of data, making computations difficult. Effective use and analysis of these data for NGS-based resequencin.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.15
- DOI:
- 10.4238/2013.December.4.15
Prevalence and genotypic diversity of cervical human papillomavirus infection among women from an urban center in Brazil
Authors: J. Coser, T. da Rocha Boeira, D. Simon, A.S. Kazantzi Fonseca, N. Ikuta and V.R. Lunge
Human papillomavirus (HPV) infection is a common viral sexually transmitted infection and the main cause of cervical cancer in women worldwide. Epidemiological data on the prevalence of HPV in a given population is essential for the establishment of effective prevention strategies. The aim of this study was to determine HPV prevalence in women who attende.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.19.3
- DOI:
- 10.4238/2013.February.19.3
Transcriptome network analysis of potential candidate genes for heart failure
Authors: J. Chen, H.Y. Wang and C.Y. Zeng
The purpose of this study was to examine the hypothesis that a transcriptome network can be developed through a set of transcription factors regulated by the expression of various genes induced by dilated cardiomyopathy can be identified and modulated to respond to heart failure. We searched for significant pathways related to dilated cardiomyopathy using.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.7
- DOI:
- 10.4238/2013.October.18.7
Construction of single-chain variable fragment antibodies against MCF-7 breast cancer cells
Authors: A.A. Zuhaida1, A.M. Ali1,2, S. Tamilselvan3, N.B. Alitheen3, M. Hamid1,4, A.M. Noor2 and S.K. Yeap1
A phage display library of single chain variable fragment (scFv) against MCF-7 breast cancer cells was constructed from C3A8 hybridoma cells. RNA from the C3A8 was isolated, cDNA was constructed, and variable heavy and light immunoglobulin chain gene region were amplified using PCR. The variable heavy and light chain gene regions were combined with flexib.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.5
- DOI:
- 10.4238/2013.November.18.5
Prevalence of diabetes and impaired fasting glucose in Uygur children of Xinjiang, China
Authors: J. Zhang1, Y.T. Ma1, X. Xie1, Y.N. Yang1, F. Liu2, X.M. Li1, Z.Y. Fu1, X. Ma1, B.D. Chen2, Y.Y. Zheng1, Z.X. Yu1 and Y. Chen1
This study was designed to estimate the prevalence of diabetes and impaired fasting glucose (IFG) in Xinjiang children in western China. Data were obtained from the Chun-Miao Project, a community-based, cross-sectional study designed to investigate the prevalence and risk factors of diabetes in children of the Chinese Uygur population in Xinjiang from Feb.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.13
- DOI:
- 10.4238/2013.October.24.13
Influence of the human MIF promoter polymorphism on hepatocellular carcinoma prognosis
Authors: T. Yuan, C. Tang, M. Chen, S. Deng and P. Chen
Hepatocellular carcinoma (HCC) is one of the most common worldwide malignancies. A relative complete diagnosis system for primary carcinoma of liver has already been established, but the surgical prognosis for HCC, which depends mainly on postoperative pathological classification and data of recurrence and metastasis, lacks valid experimental indicators. .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.January.4.3
- DOI:
- 10.4238/2013.January.4.3