Human Genetics
Cytotoxic effects of essential oils from three Lippia gracilis Schauer genotypes on HeLa, B16, and MCF-7 cells and normal human fibroblasts
Authors: J.O. Melo, A.L. Fachin, W.F. Rizo, H.C.R. Jesus, M.F. Arrigoni-Blank, P.B. Alves, M.A. Marins, S.C. Fran�§a and A.F. Blank
This study aimed to evaluate the chemical composition of the essential oils from three genotypes of Lippia gracilis Schauer (Verbenaceae) and investigate the cytotoxic activities of these oils. Essential oils were extracted from the leaves using a Clevenger-type apparatus, and chemical analysis was performed using a gas chroma.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.12
- DOI:
- 10.4238/2014.April.8.12
Effect of atorvastatin on vascular endothelial function in moderately nicotine-dependent smokers
Authors: X.Z. Cao, Z.R. Luo, H.M. Zhang and J.Q. Cai
We investigated the effect of atorvastatin on vascular endothelial function in moderately nicotine-dependent smokers. One hundred and sixty moderately nicotine-dependent smokers were randomly divided into the atorvastatin group (N = 80) and the control group (N = 80). Total cholesterol (TC), triglyceride, high-density lipoprot.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.13
- DOI:
- 10.4238/2014.April.8.13
Population variability of Bemisia tabaci (Genn.) in different hosts
Authors: G.E. do Valle, A.L. Louren�§�£o, M.I. Zucchi, J.B. Pinheiro and A.G. de Abreu
The silverleaf whitefly, Bemisia tabaci (Genn.) (Hemiptera: Aleyrodidae), is a cryptic species complex that contains some of the most damaging pests in tropical and subtropical regions. Recent studies have indicated that this complex is composed of at least 24 distinct and morphologically indistinguishable species that mainly differ in their ability to tr.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.17.4
- DOI:
- 10.4238/2013.October.17.4
Ginkgo biloba extract postconditioning reduces myocardial ischemia reperfusion injury
Authors: K. Ran, D.-L. Yang, Y.-T. Chang, K.-M. Duan, Y.-W. Ou, H.-P. Wang and Z.-J. Li
We examined the protective effects of Ginkgo biloba extract (EGb761) postconditioning on myocardial ischemia reperfusion injury in rabbits. Four groups of 8 white rabbits were allocated to: pseudo surgery group: the left coronary was lined without blocking for 160 min after thoracotomy; ischemia and reperfusion group (IR): the.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.14
- DOI:
- 10.4238/2014.April.8.14
Expression of RUNX3 gene in pancreatic adenocarcinoma and its clinical significance
Authors: L.-N. Xue, F.H. Bai2, X.-Y. Wang1, M. Lin1, Y. Tan1,2, X.-Y. Yao1 and K.-Q. Xu
We investigated the clinical significance of RUNX3 gene expression in human pancreatic carcinoma. Five samples of pancreatic tissues and 30 samples of pancreatic cancer tissues and paracancerous tissues were collected. RUNX3 expression was detected by real-time PCR and immunohistochemistry. The relationships between clinicopat.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.23.4
- DOI:
- http://dx.doi.org/10.4238/2014.May.23.4
Association between primary open angle glaucoma and genetic polymorphisms GSTM1/GSTT1 in patients from Goi�¢nia Central-West Region of Brazil
Authors: C.T.X. Silva, N.B. Costa, K.S.F. Silva, R.E. Silva and K.K.V.O. Moura
In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polyme.. Read More»
- Genet. Mol. Res. 13(4):
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma
Authors: H.T. Niu, X.J. Qi, Y.Q. Liu, Y.W. Cao, Q. Dong and X.S. Wang
To bring about improvements in cancer biology research and elucidate mechanism-based therapeutic targets, we studied the proteome expression profile of purified normal urothelial cells (cancer cells) and normal stromal cells (cancerous stromal cells). Based on the expression profile, biomarker discovery and the mechanisms of multi-step carcinogenesis were.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.28
- DOI:
- 10.4238/2013.February.28.28
Karyotype analysis of Rheum palmatum
Authors: J.Q. Ye, Y.Y. Jia, K. Fan, X.J. Sun and X.M. Wang
Rheum palmatum, one of the source plants of the traditional Chinese medicine rhubarb, is anendemic and endangered species. To our knowledge, this is the first report on the chromosome number and karyotype of this species. Sectioning combined with micrography was used to analyze the karyotype. The following results were obtained: R. palmatum had a stable c.. Read More»
- Genet. Mol. Res. 13(4):
In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells
Authors: M.A. Ali, M. Abul Farah, F.M. Al-Hemaid and F.M. Abou-Tarboush
This study investigated the in vitro anticancer activities of a total of 14 wild angiosperms collected in Saudi Arabia. The cytotoxic activity of each extract was assessed against human breast adenocarcinoma (MCF-7) cell lines by using the MTT assay. Among the plants screened, the potential cytotoxic activity exhibited by the .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.23.9
- DOI:
- http://dx.doi.org/10.4238/2014.May.23.9
Bulked segregant analysis of the pirarucu (Arapaima gigas) genome for identification of sex-specific molecular markers
Authors: I.G. Almeida, P. Ianella, M.T. Faria, S.R. Paiva and A.R. Caetano
Arapaima gigas (Osteoglossidae) is one of the largest fish species in the Amazon Basin, attaining lengths of over 2.5 m and weights of over 100 kg. Its flesh is prized, and it has great potential for production in aquaculture systems. However, live pirarucu cannot be reliably sexed visually, even after sexual development, since this species does not have .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.17
- DOI:
- 10.4238/2013.December.4.17