Human Genetics
Genome-wide multilocus analysis of intraspecific differentiation in Oryza rufipogon Griff. from China and the influence of introgression from O. sativa L.
Authors: Y.B. Dong, F. Li, X.W. Pei, F. Wang, Q.H. Yuan, H.J. Wu, S.R. Jia, Y.F. Peng
Twenty-five populations of Oryza rufipogon from China and 144 cultivars of Oryza sativa were selected for this study. Based on the DNA fragment of Ehd1-4 and subspecies-specific sequence-tagged site markers in different chromosomes, intraspecific differentiation in O. rufipogon from China was analyzed. The introgression from O.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.8
- DOI:
- 10.4238/2013.December.2.8
Association of transforming growth factor-beta 1 gene polymorphism with genetic susceptibility to ossification of the posterior longitudinal ligament in Korean patients
Authors: I.B. Han, A.E. Ropper, Y.J. Jeon, H.S. Park, D.A. Shin, Y.D. Teng, S.-U. Kuh and N.-K. Kim
Ossification of the posterior longitudinal ligaments (OPLL) has been considered to be associated with abnormalities of bone metabolism, and transforming growth factor-β1 (TGF-β1) has been demonstrated to affect the bone remodeling process. We investigated two SNPs of the TGF-β1 promoter (-509C>T; rs1800469) and exon 1 (869T>C; rs19820.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.26
- DOI:
- 10.4238/2013.February.28.26
Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis
Authors: L.Wang, Z.T. Wang, J.J. Hu, R. Fan, J. Zhou and J. Zhong
The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inco.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.2
- DOI:
- 10.4238/2014.April.8.2
Effect of chromosome constitution variations on the expression of Turner phenotype
Authors: A.V.S. Bispo, L.O. dos Santos, P. Bur�©gio-Frota, M.B. Galdino,A.R. Duarte, G.F. Leal, J. Ara�ºjo, B. Gomes, E.M. Soares-Ventura, M.T.C. Muniz and N. Santos
Turner syndrome (TS) is a chronic disease related to haploinsufficiency of genes that are normally expressed in both X chromosomes in patients with female phenotype that is associated with a wide range of somatic malformations. We made detailed cytogenetic and clinical analysis of 65 patients with TS from the region of Recife, Brazil, to determine the eff.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.March.13.13
- DOI:
- 10.4238/2013.March.13.13
Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome
Authors: S.B. Lecke, D.M. Morsch and P.M. Spritzer
We reviewed emerging evidence linking serum levels and adipose tissue expression of leptin and adiponectin in women with polycystic ovary syndrome (PCOS). Previous data obtained by our group from a sample of overweight/obese PCOS women and a control sample of normal weight controls, both stratified by BMI, were reanalyzed. Circulating levels of leptin and.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.16
- DOI:
- 10.4238/2013.February.28.16
Differentiation of neonatal dorsal root ganglion-derived neural stem cells into oligodendrocytes after intrathecal transplantation into a cauda equina lesion model
Authors: Z.Y. Fu, J.G. Shi, N. Liu, L.S. Jia, W. Yuan, Y. Wang
Cauda equina syndrome (CES) is characterized by varying patterns of low back pain, sciatica, lower extremity sensorimotor loss, and bowel and bladder dysfunction. The prognosis for complete recovery of CES is dependent on not only the time before surgical intervention with decompression but also the severity of the nerve damag.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.7
- DOI:
- 10.4238/2013.December.2.7
Gene polymorphisms associated with susceptibility to coronary artery disease in Han Chinese people
Authors: Y.H. Liu, Y.W. Zhou, J.A.Yang, Z.G. Tu, S.Y. Ji, Z.Y. Huang and Z.J. Zhou
This study investigated 5 single nucleotide polymorphism (SNP) haplotypes in susceptibility genes for coronary artery disease (CAD) and the putative involvement of these SNPs in CAD in the Chinese Han population. From March 2008 to June 2009, we selected 119 CAD patients and 115 subjects not related to the CAD of Chinese Han o.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.4
- DOI:
- 10.4238/2014.April.8.4
Regulation network analysis of testicular seminoma at various stages of progression
Authors: J.-J. Sha, Y.-H. Dong, D.-M. Liu, J.-J. Bo, Y.-R. Huang, Z. Li and P. Ping
Testicular seminoma has become the most common solid malignancy in young men, especially in the 20s group. We obtained the gene expression profile of human testicular seminoma cells from NCBI, identified the differentially expressed genes of testicular seminoma cells of different stages, and constructed the regulation networks of different stages of testi.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.March.11.11
- DOI:
- 10.4238/2013.March.11.11
Effect of erythropoietin on mesenchymal stem cell differentiation and secretion in vitro in an acute kidney injury microenvironment
Authors: N.M. Liu, J. Tian, W.W. Wang, G.F. Han, J. Cheng, J. Huang and J.Y. Zhang
We investigated the effect of erythropoietin (EPO) on differentiation and secretion of bone marrow-derived mesenchymal stem cells in an acute kidney injury microenvironment. Acute kidney injury mouse models were prepared. Both renal cortices were then immediately collected to produce the ischemia/reperfusion kidney homogenate supernatant. The morphologica.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.14
- DOI:
- 10.4238/2013.February.28.14
Changes of Th1/Th2 cytokines in immunocompetent patients with pulmonary cryptococcosis
Authors: J.L. Wang, S.Y. Li, Y.F. Luo, Y.P. Zhai and X.Q. Wei
The aim of this study was to investigate the changes of Th1/Th2 cytokines in immunocompetent patients with pulmonary cryptococcosis (PC). Twenty immunocompetent patients with PC were identified by histopathological examination and were enrolled in the study along with the age- and gender-matched healthy controls. The serum concentrations of interferon-g (.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.22
- DOI:
- 10.4238/2013.November.18.22