Human Genetics
Study on the treatment of the p15 gene combined with Bcr-abl-specific siRNA and STI571 for chronic myeloid leukemia
Authors: W. Wang, Y. Du, N.-N. Li, F.-F. Lv and G.-Q. Lin
The aim of this study was to investigate the effect of the p15 gene combined with Bcr-abl-specific siRNA and STI571 on the proliferation, cell cycle and apoptosis of K562 chronic myeloid leukemia cells. Using the gene sequence results, we amplified the p15 gene from normal peripheral blood by RT-PCR, and constructed a p15-pcDN.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.4
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.4
Association between CASP-8 gene polymorphisms and cancer risk in some Asian population based on a HuGE review and meta-analysis
Authors: Y.J. Zhang, X.P. Zhong, Y. Chen, S.R. Liu, G. Wu and Y.F. Liu
Genetic variation in the CASP-8 gene reportedly can increase cancer susceptibility by regulating tumor cell proliferation and apoptosis. Several studies have investigated this possibility; however, the conclusions remain controversial. We made a Human Genome Epidemiology (HuGE) review and did a meta-analysis to explore the association between CASP-8 gene .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.3
- DOI:
- 10.4238/2013.February.28.3
Expression and purification of GST-FHL2 fusion protein
Authors: H. Yu, Q. Ma, J. Lin, Y.F. Sun and F. Zheng
Escherichia coli is the most widely used host for the production of recombinant proteins. However, most eukaryotic proteins are typically obtained as insoluble, misfolded inclusion bodies that need solubilization and refolding. The interactions between human FHL2 protein and many types of proteins, including structural proteins, kinases, and several class.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.6.4
- DOI:
- 10.4238/2013.December.6.4
Oct4 and Sox2 overexpression improves the proliferation and differentiation of bone mesenchymal stem cells in Xiaomeishan porcine
Authors: Y.X. Fan, C.H. Gu, Y.L. Zhang, B.S. Zhong, L.Z. Wang, Z.R. Zhou,Z.Y. Wang, R.X. Jia, F. Wang
Mesenchymal stem cells derived from bone marrow (BMSCs) are a population of self-renewing multipotent cells that are capable of differentiating into various cellular lineages, and are widely employed in tissue engineering and cell therapy. Recently, clinical research involving BMSCs has become increasingly popular. In order to.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.5
- DOI:
- 10.4238/2013.December.2.5
Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population
Authors: L. Wang, Z-T. Wang, H-X. Zhang, J. Liu, S-Y. Lu, R. Fan, J. Zhou, L. Xia, Y-W. Sun, J. Zhong, and Y-Z. Yuan
Ulcerative colitis (UC) is a chronic inflammation of the large intestine. The aim of this study was to investigate the association of two polymorphisms in STAT3 with the risk of UC development in the Chinese Han population. This is a hospital-based case-control study involving 56 UC patients and 274 controls. Genotyping was pe.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.6
- DOI:
- 10.4238/2014.April.3.6
Development and characterization of polymorphic microsatellite markers for Chinese raccoon dog (Nyctereutes procyonoides procyonoides)
Authors: S.Q. Yan, Y.M. Li, C.Y. Bai, X.M. Ding, W.J. Li, J.N. Hou,Z.H. Zhao and J.H. Sun
Chinese raccoon dog (Nyctereutes procyonoides procyonoides) is one of the most important fur-bearing animal species. Information about the genetic background of farmed Chinese raccoon dogs is limited. In this study, 17 polymorphic microsatellite markers were isolated and identified from an (AC)n-microsatellite-enriched library of Chinese raccoon dogs. The.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.6.2
- DOI:
- 10.4238/2013.December.6.2
Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients
Authors: L. Han1,2, X.J. Xu1,2, X.H. Liang1,2 and J. Ma1,2
We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essentia.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.30.2
- DOI:
- 10.4238/2013.October.30.2
Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women
Authors: L. GÃ?³mez Flores-Ramos1,2, A. Escoto-De Dios1, A.M. Puebla-PÃ?©rez3, L.E. Figuera-Villanueva4, A. Ramos-Silva1,5, R. RamÃ?Ârez-PatiÃ?±o1,2, J.I. Delgado-Saucedo3, E. Salas-GonzÃ?¡lez6, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez7, A. Alonzo-Rojo1,2, I. GutiÃ?©rrez-Hurtado1,2 and M.P. Gallegos-Arreola1
The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.17
- DOI:
- 10.4238/2013.November.18.17
Predicting the target genes of microRNA based on microarray data
Authors: B. Cao, T. Ji, B. Zhou, J. Zou, G.Q. Jiao
MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides in length, which play important roles in regulating gene expression post-transcriptionally. Several computational methods and algorithms have been developed to predict miRNA targets. In this study, we described a method that can be used to integrate m.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.4
- DOI:
- 10.4238/2013.December.2.4
A novel splicing site mutation of the GPR143 gene in a Chinese X-linked ocular albinism pedigree
Authors: C.Y. Cai1*, H. Zhu2*, W. Shi1*, L. Su3*, O. Shi4, C.Q. Cai5, C. Ling1 and W.D. Li1
Ocular albinism is an X-linked inherited disease characterized by hypopigmentation of the iris and nystagmus. To identify a new disease-causing mutation of ocular albinism, we collected a Han Chinese pedigree with 7 male congenital nystagmus patients over 3 generations. Slit-lamp photography and optical coherence tomography were performed for the proband... Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.16
- DOI:
- 10.4238/2013.November.18.16