Human Genetics
Association of monocyte chemoattractant protein-1 rs1024611 and telomerase rs2736100 polymorphisms with susceptibility to pulmonary tuberculosis in Han Chinese population
Authors: G.H. Cheng, X.L. Wang, X.T. Yuan, Q. Xin, Q. Sun, K.L. Li, C. Sun, Z.M. Lin, Y. Luan, Y.S. Wang, F. Kong and D.W. Xu
Pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis infection and accumulated evidence reveals the genetic context of its infection phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant is shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In a.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039697
- DOI:
- 10.4238/gmr16039697
Pharmacogenetics-based warfarin dose prediction algorithm for patients with heart valve replacement in Southeast China
Authors: M.Q. Lin, J. Zhang, H.F. Qiu, X.B. Xie and H.T. Song
This study was designed to analyze the influence of polymorphisms in CYP2C9, VKORC1, CYP4F2, GGCX, and EPHX1 genes on the optimal warfarin dosage in patients who have undergone artificial heart valve replacement and establish an algorithm for use by physicians in Southeast China to predict each patient’s optimal steady-s.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16038881
- DOI:
- 10.4238/gmr16038881
Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis
Authors: E.V.W. dos Santos, L.N.R. Alves and I.D. Louro
A role for estrogen in the etiology of breast and ovarian cancers has been suggested; therefore, genetic polymorphisms in steroid metabolism genes could be involved in the carcinogenesis of these tumors. We have aimed to investigate the role of GSTP1 and CYP17 polymorphisms and their correlation with MSI (microsatellite instab.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039691
- DOI:
- 10.4238/gmr16039691
Mitochondrial DNA control region analysis of three ethnic populations in lower Northern part of Thailand
Authors: U. Suyasunanont, M. Nakkuntod and S. Mirasena
The lower northern part of Thailand contains various genetically diverse ethnic populations. The sequences of the mitochondrial DNA hypervariable region were studied in three ethnic populations inhabiting Phitsanulok Province. One hundred and nine nucleotide sequences - 53, 29, and 27 from Hmongs (Hill tribe), Lao Songs, and T.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039687
- DOI:
- 10.4238/gmr16039687
Molecular analysis of the GSTT1 gene polymorphism in patients with clinical manifestation of atherosclerosis
Authors: J.V.M. Martins, D.A. Rodrigues, K.S.F. Silva, I.R. Costa, M.H. Lagares, F.L. Campedelli, A.M. Barbosa, M.P. Morais and K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regu.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039620
- DOI:
- 10.4238/gmr16039620
Improvement in orthopedic outcome score and reduction in IL-1�², CXCL13, and TNF-�± in synovial fluid of osteoarthritis patients following arthroscopic knee surgery
Authors: Z.M. Li and M. Li
Knee osteoarthritis (KOA) is a common degenerative joint disease and immune system dysregulation has been implicated in its pathogenesis. The effect of arthroscopic knee surgery, an important method for KOA diagnosis and treatment, on the expression of immune regulators remains poorly understood. We aimed to investigate the cl.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039487
- DOI:
- 10.4238/gmr16039487
Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues
Authors: H.B. Xia, H.W. Cui, L. Su, Z.H. Zhang, X.Y. Yang, S.Q. Ning and X.L. Su
We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using im.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039278
- DOI:
- 10.4238/gmr16039278
Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population
Authors: Z. Fang, M. Li, Z. Ma and G. Tu
Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, t.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16037446
- DOI:
- 10.4238/gmr16037446
Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU
Authors: Y.X. Fan, P. Abulimiti, H.L. Zhang, Y.K. Zhou and L. Zhu
Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029414
- DOI:
- 10.4238/gmr16029414
Haplotypes and polymorphism in the CCR5 gene in sickle cell disease
Authors: A.F. Nascimento, J.S. Oliveira, J.C. Silva Junior and A.A.L. Barbosa
Sickle cell disease shows several clinical manifestations in distinct levels of severity. This heterogeneity is due to the haplotype variability associated with the HbS gene, levels of fetal hemoglobin and environmental conditions, which modify the disease expression. Science community believes that the presence of a polymorph.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029675
- DOI:
- 10.4238/gmr16029675