Human Genetics
Clinical significance of fascin-1 and laminin-5 in non-small cell lung cancer
Authors: L. Yang, Y. Teng, T.-P. Han, F.-G. Li, W.-T. Yue and Z.-T. Wang
Lung cancer is the leading cause of cancer death in men and the second leading cause of cancer death in women worldwide. Fascin-1 and laminin-5 were associated with the invasiveness and prognoses of several cancers. The expression and the serum levels of fascin-1 and laminin-5 in patients with non-small cell lung cancer (NSCLC.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029617
- DOI:
- 10.4238/gmr16029617
Cytogenetic aspects of a canine breast carcinosarcoma - a case report
Authors: C.S.D. Morais, P.R.A.M. Affonso, J.A. Bitencourt and A.A. Wenceslau
This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterati.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029433
- DOI:
- 10.4238/gmr16029433
Effect of 1,25(OH)2D3 on the proliferation of human mesangial cells and their expression of Ki67
Authors: D. Zhao, C.-J. Zhang, R. Yang, J.-P. Chen, L. Ma, G. Liu and X.-P. Yang
Previous studies have found that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 or VD3] exerts many biological effects, including the inhibition of cell proliferation and induction of apoptosis, but its mechanism of action remains unclear. The goal of our investigation was to explore the effects of 1,25(OH)2D3 on the proliferation of c.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029191
- DOI:
- 10.4238/gmr16029191
Study on the association of UGT1A9 gene c.98T>C polymorphism and mycophenolic acid plasma levels in renal transplant patients
Authors: L.R. Ruschel, V.M. Schmitt, A.B. Silva, C.S.A. Oliveira, K. Flach, D.O. d�Avila and F.V. Thiesen
Mycophenolate mofetil (MMF) is a prodrug active only after its hydrolysis to mycophenolic acid (MPA). The UGT1A9 enzyme is of special interest since it is the main enzyme involved in the glucuronidation of MPA. Single nucleotide polymorphisms (SNPs) in the UGT1A9 gene may be responsible for individual differences in the pharma.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029598
- DOI:
- 10.4238/gmr16029598
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population
Authors: V.R.Z.B. Pereira, J.M. Wolf, G.Z. Stumm, T.R. Boeira, J. Galvan, D. Simon and V.R. Lunge
Hepatitis B virus (HBV) infection is a serious public health problem worldwide. The progression of the disease depends on several host and viral factors and may result in fulminant hepatitis (very rare), acute hepatitis with spontaneous clearance, and chronic hepatitis B infection. Previous studies demonstrated that variations.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029565
- DOI:
- 10.4238/gmr16029565
Effect of Shenqin biochemical extract on hypoxia-inducible factor-1�± expression in ultraviolet B-irradiated HaCaT cells
Authors: X. Chen, J. Bai, Y. Li, X.-G. Li1, G.-F. Lv and H.-Ch. Zhang
Hypoxia-inducible factor-1α (HIF-1α) is considered the main transcriptional regulator of the hypoxia-specific cellular and developmental response. This study was performed to investigate the effect of Shenqin biochemical extract (SQBE) on HIF-1α expression in ultraviolet B (UVB)-irradiated HaCaT cells and the.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029430
- DOI:
- 10.4238/gmr16029430
Association between the -77T>C polymorphism in the DNA repair gene XRCC1 and lung cancer risk
Authors: B.B. Sun, J.Z. Wu, Y.G. Li and L.J. Ma
Numerous studies have evaluated the association between the X-ray repair cross-complementing group 1 (XRCC1) DNA repair gene polymorphism -77T>C and lung cancer risk. However, this association is controversial. We used PubMed and Embase to identify 5 case-control studies, which included 2488 lung cancer cases and 2576 controls, for inclusion in a compr.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.17
- DOI:
- 10.4238/2014.December.4.17
MTA1 promotes cell proliferation via DNA damage repair in epithelial ovarian cancer
Authors: Q.Y. Yang1, J.H. Li2, Q.Y. Wang3, Y. Wu3, J.L. Qin3, J.J. Cheng3 and J. Qiu3
We examined whether metastasis-associated gene 1 (MTA1) promotes cell proliferation via DNA damage repair in ovarian cancer. MTA1 was successfully down-regulated using small interfering RNA in the epithelial ovarian cancer cell lines SKOV-3 and OVCAR-3. Cell growth was evaluated through MTT and colony formation assays. Fluorescence-activated cell sorting .. Read More»
- Genet. Mol. Res. 13(4):
Distribution of constitutive heterochromatin in species of triatomines with fragmentation of sex chromosomes X
Authors: A.L. Guerra1, K.C.C. Alevi1, J.A. Rosa2 and M.T.V. Azeredo-Oliveira1
Cytogenetic analyses of triatomines are considered to be important taxonomic tools. Thus, we analyzed the pattern of constitutive heterochromatin in 7 species of triatomine with fragmentation of the sex chromosome X, focusing on the cytotaxonomy of these triatomines. The species analyzed included Triatoma vitticeps, Triatoma melanocephala, Triatoma tibiam.. Read More»
- Genet. Mol. Res. 13(4):
Influence of aberrant myeloid expression on acute lymphoblastic leukemia in children and adolescents from Maranh�£o, Brazil
Authors: T.C. Lopes1, K.N.S. Andrade1, N.L. Camelo1, V.P. Rodrigues2 and R.A.G. Oliveira3
The aim of this study was to evaluate myeloid expression in acute lymphoblastic leukemia (ALL) in children and adolescents who had been referred to the Oncology Department in a hospital in the State of Maranhão based on demographic, laboratory, and clinical data. Myeloid expression was evaluated in 65 patients under 18 years of age who were diagnos.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.25
- DOI:
- 10.4238/2014.December.4.25