Human Genetics
DNA barcoding for species identification in the Palmae family
Authors: A. Naeem1, A.A. Khan1, H.M.N. Cheema1, I.A. Khan1 and A. Buerkert2
DNA barcoding is a promising tool for species identification at the molecular level. The barcoding system is well established for species differentiation in animals, while it is less common in plants. We evaluated 2 barcoding regions, maturase K (matK) and ribulose bisphosphate carboxylase (rbcL), to compare species of Palmae according to amplification su.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.29
- DOI:
- 10.4238/2014.December.4.29
Correlation between the NPPB gene promoter c.-1298 G/T polymorphism site and pulse pressure in the Chinese Han population
Authors: K. Zeng, X.D. Wu, H.D. Cai, Y.G. Gao, G. Li , Q.C. Liu, F. Gao, J.H. Chen and C.Z. Lin
The aim of this study was to investigate the correlation between the natriuretic peptide precursor B (NPPB) gene single nucleotide polymorphism (SNP) c.-1298 G/T and pulse pressure (PP) of the Chinese Han population and the association between genotype and clinical indicators of hypertension. Peripheral blood was collected fro.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.4
- DOI:
- 10.4238/2014.April.29.4
Risk factors for the development of essential hypertension in a Mongolian population of China: a case-control study
Authors: N. Dalai, H. Cui, M. Yan, G. Rile, S. Li and X. Su
Lifestyle, habits, diet, and genetics are all important factors associated with the prevalence of hypertension. Many association studies have been performed in the Chinese Han population, whereas data explaining the high prevalence of hypertension in the Mongolian population remain scarce. In the present study, we aimed to det.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.6
- DOI:
- 10.4238/2014.April.29.6
Genetic polymorphisms of paraoxonase1 192 and glutathione peroxidase1 197 enzymes in familial Mediterranean fever
Authors: F. ��ktem, H. An�±l, R. S�¼tc�¼ and A.E. Kuybulu
Familial Mediterranean fever (FMF) is an autosomal recessive disorder and is the most frequent of the periodic febrile inflammatory syndromes. The pathogenesis of the disease is not completely understood, even though the FMF gene has been identified. Oxidative stress and inflammation may play a role in the pathogenesis of FMF... Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.7
- DOI:
- 10.4238/2014.April.29.7
Association of xeroderma pigmentosum group D (Asp312Asn, Lys751Gln) and cytidine deaminase (Lys27Gln, Ala70Thr) polymorphisms with outcome in Chinese non-small cell lung cancer patients treated with cisplatin-gemcitabine
Authors: M. Zhou, Y.J. Ding, Y. Feng, Q.R. Zhang, Y. Xiang and H.Y. Wan
Xeroderma pigmentosum group D (XPD) plays a key role in the repair of DNA and platinum resistance lesions. Cytidine deaminase (CDA) genes determine the velocity of gemcitabine catalysis. This study aimed to investigate the relationship between XPD and CDA genotypes and outcome in non-small lung cancer (NSCLC) patients. We used.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.9
- DOI:
- 10.4238/2014.April.29.9
miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population
Authors: Y.F. Shan1, Y.H. Huang1, Z.K. Chen1, K.T. Huang1, M.T. Zhou1, H.Q. Shi1, Q.T. Song1, Z.P. Yu1, A.M. Deng2 and Q.Y. Zhang1
We conducted a case-control study of a possible association of miR-499A>G rs3746444 and miR-146aG>C rs2910164 with risk of hepatocellular carcinoma. Samples from 172 hepatocellular carcinoma patients and 185 cancer-free controls were collected from October 2008 to December 2011. PCR-RFLP analysis was performed to determine the polymorphisms in each .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.7.11
- DOI:
- 10.4238/2013.November.7.11
Study of candidate genes for dyslexia in Brazilian individuals
Authors: M.C.C.M. Svidnicki1, C.A. Salgado2, R.F. Lima2, S.M. Ciasca2, R. Secolin3, M.C.A. Pomilio4, P.A. Junqueira4, M.S. Pinto4, M.M. Pereira4 and E.L. Sartorato1
Dyslexia or reading disability (RD) is the most common childhood learning disorder and a significantly heritable trait. Many recent studies have investigated the genetic basis of dyslexia, and several candidate genes have been proposed. Among these, DCDC2 and KIAA0319 have emerged as the strongest candidate genes for dyslexia; however studies have not pro.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.7.10
- DOI:
- 10.4238/2013.November.7.10
ADAMTS14 gene polymorphism associated with knee osteoarthritis in Thai women
Authors: T. Poonpet1,2, S. Honsawek3, N. Tammachote4, S. Kanitnate4,R. Tammachote2
Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. This disease is characterized by breakdown and loss of articular cartilage due to genetic, mechanical and environmental factors. Although the pathophysiology of OA is not completely known, several candidate genes have been reported to be associated with OA susceptibility. We asses.. Read More»
- Genet. Mol. Res. 13(4):
- 2013.November.7.5
- DOI:
- 10.4238/2013.November.7.5
Relationship between serum neopterin levels and coronary heart disease
Authors: Z.Y. Liu and Y.D. Li
The relationship between serum neopterin levels and coronary heart disease (CHD) was investigated. Eighty-six CHD patients were divided into an acute myocardial infarction (AMI) group (N = 21), an unstable angina pectoris (UAP) group (N = 35), and a stable angina pectoris (SAP) group (N = 30), based on coronary angiography (CAG), 30 subjects without CHD s.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.7.8
- DOI:
- 10.4238/2013.October.7.8
Association of chemotactic factor receptor 5 gene with breast cancer
Authors: Y. Zhang1, F.Y. Meng2, W.L. Li1, C.X. Zhou1, Z. Guan1 and H.Y. Fan2
We designed a 2-stage study to investigate chemotactic factor receptor 5 (CCR5) gene expression in breast cancer tissues and axillary lymph nodes and analyze the association between the CCR5-Δ32 gene polymorphism and the clinical features and prognosis of breast cancer patients. The first stage examined 72 cases of invasive ductal carcinoma and axil.. Read More»
- Genet. Mol. Res. 13(3):
- 2013.November.7.4
- DOI:
- 10.4238/2013.November.7.4