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Association of monocyte chemoattractant protein-1 rs1024611 and telomerase rs2736100 polymorphisms with susceptibility to pulmonary tuberculosis in Han Chinese population

Author(s): G.H. Cheng, X.L. Wang, X.T. Yuan, Q. Xin, Q. Sun, K.L. Li, C. Sun, Z.M. Lin, Y. Luan, Y.S. Wang, F. Kong and D.W. Xu

Pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis infection and accumulated evidence reveals the genetic context of its infection phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant is shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In addition, telomerase plays a key role in immunocompetence, and the telomerase reverse transcriptase (TERT) polymorphism is associated with susceptibility to different diseases. We, thus, determined the relationship between MCP-1 rs1024611 and TERT rs2736100 variants and PTB susceptibility by genotyping 183 Han Chinese patients with active PTB and 210 ethnicity/age/sex-matched healthy controls. The rs1024611_GG genotype was found at a higher frequency in controls than in patients with PTB. The GA genotype exhibited significantly reduced risk of PTB (P = 0.03). When GA and AA genotypes were grouped together, the GG variant remained at a significantly higher risk for PTB (P = 0.042). Further analyses revealed that the risk occurred in males, but not females (P = 0.037). There was no difference in TERT rs2736100 genotypes between controls and patients, suggesting the lack of association of this genetic variant with PTB risk. Taken together, Han Chinese male rs1024611_GG-carriers exhibit a significantly higher susceptibility to active PTB.


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