Colorectal Cancer
Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer
Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy
Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer .. Read More»
- Genet. Mol. Res. 18(1):
Relationship between melanoma-associated antigen 1 (MAGE-A1) gene polymorphisms and colorectal cancer development
Authors: Mikhlid Almutairi and Abdelhabib Semlali
In the Saudi population, colorectal cancer (CRC) is the first and third most common malignancy among males and females, respectively. The CRC risk is associated with the expression of certain genes, which can be used for prognoses and for finding screening-related biomarkers. One such gene is melanoma-associated antigen 1 (MAGE-A1); however, little is kno.. Read More»
- Genet. Mol. Res. 18(4):
Clinical and molecular findings in an Albanian family with familial adenomatous polyposis
Authors: P. E. Maltese, G. Di Saverio, E. Manara, F. Fanelli, N. Capodicasa, D. Guraj, I. Shehaj, B. Amato, A. Babameto-Laku, S. Michelini , M. Bertelli
Purpose: Familial adenomatous polyposis is an inherited precancerous condition characterized by multiple colorectal polyps. This brief report describes three generations of a family with a history of colorectal cancer in which genetic testing was useful for detecting individuals at risk. Methods: A next generation sequencing c.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039823
- DOI:
- 10.4238/gmr16039823
DNA methylation profile of the DKK2 gene as a biomarker in patients with colorectal cancer
Authors: T.D. Silva, A.V. Felipe, V.M. Vidigal, S.S. Saad, N.M. Forones
Purpose: Epigenetic changes can be detected in precancerous lesions, suggesting that may be involved in the early stages of carcinogenesis. The methylation of specifics genes has been correlated with the outcome of many different types of cancers. This study compared the levels of DNA methylation between normal and tumor tissu.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039816
- DOI:
- 10.4238/gmr16039816
Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU
Authors: Y.X. Fan, P. Abulimiti, H.L. Zhang, Y.K. Zhou and L. Zhu
Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029414
- DOI:
- 10.4238/gmr16029414
Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population
Authors: C.-P. Zhou, H.-Z. Pan, F.-X Li, N.-Y. Hu, M. Li and X.-X. Yang
Evidence suggests that some genetic variants are risk factors for both colorectal cancer (CRC) and gastric cancer (GC). Thus, we selected 12 reported single nucleotide polymorphisms (SNPs) from genome-wide association studies of CRC and conducted this case-control study to assess the associations between these SNPs and the ris.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.9.10
- DOI:
- http://dx.doi.org/10.4238/2014.May.9.10
Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population
Authors: J.M. Moreno-Ortiz, M. GutiÃ?©rrez-Angulo, M. Partida-PÃ?©rez, J. Peregrina-Sandoval, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz- endoza, S. SuÃ?¡rez-Villanueva, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, J.E. Cabrales-Vazquez and M.L. Ayala-Madrigal
Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor invasion and metastasis. The objective of this study was to analyze the association of functional MMP7-181A/G and MMP13-77A/G promoter polymorphisms .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.1
- DOI:
- 10.4238/2014.February.14.1
Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility
Authors: L.Z. Zhang, Y.S. Li and H.Z. Liu
Numerous studies have evaluated the relationship between the T241M polymorphism of the X-ray repair cross-complementing group 3 (XRCC3) gene and colorectal cancer (CRC) risk. However, the specific relationship remains controversial. We conducted meta-analysis to investigate the relationship between the XRCC3 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.48
- DOI:
- 10.4238/2015.November.18.48
MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer
Authors: R. MuÃ?±iz-Mendoza, M.L. Ayala-Madrigal, M. Partida-PÃ?©rez, J. Peregrina-Sandoval, E. Leal-Ugarte, N. MacÃ?Âas-GÃ?³mez, V. Peralta-Leal, J.P. Meza-Espinoza, J.M. Moreno-Ortiz, R. RamÃ?Ârez-RamÃ?Ârez, S. SuÃ?¡rez-Villanueva and M. GutiÃ?©rrez-Angulo
DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral b.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.27.6
- DOI:
- 10.4238/2012.June.27.6
Expression profile of the GA733 gene family in colorectal cancer: correlation with clinicopathological parameters
Authors: I. Mamaloudis, D. Zacharoulis, M. Samara, G. Papadopoulos, S. Samara, G. Koukoulis, C. Chatzitheofilou and P. Kollia
GA733-1/-2/-3 genes have been detected in various types of cancer, although their role has not been fully clarified. GA733-2 and GA733-1 have been correlated with lymph node metastases in laryngeal cancer and liver metastases, respectively. Only a few studies have elucidated the mechanisms regulating GA73.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.42
- DOI:
- 10.4238/2015.November.18.42