Colorectal Cancer
Association between ERCC1 and XPF polymorphisms and risk of colorectal cancer
Authors: H. Yang, G. Li and W.F. Li
We conducted a hospital-based case-control study to evaluate the association between polymorphisms in excision repair cross-complementing group 1-xeroderma pigmentosum group F (ERCC1-XPF) variants and the risk of colorectal cancer in a Chinese population. Genotyping of the ERCC1 rs2298881 and rs11615 and XPF rs2276466 polymorphisms were detected by polymeras.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.13
- DOI:
- 10.4238/2015.January.30.13
Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer
Authors: Y. Dong, J.W. Liu, Y.J. Gao, T. Zhou and Y.M. Chen
We examined the relationships between singlenucleotide polymorphisms (SNPs) in the DNA repair gene XPD751 and the efficacy and time to disease progression (TTP) in colorectal cancer patients after platinum-based chemotherapy. Ninety-eight patients diagnosed with advanced colorectal cancer were subjected to oxaliplatin and 5-fluorouracil combination therap.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.8
- DOI:
- 10.4238/2015.May.22.8
High frequency of microsatellite instability in sporadic colorectal cancer patients in Iran
Authors: M. Moghbeli, O. Moaven, E. Dadkhah, M. Farzadnia, N.M. Roshan, H. Asadzadeh-Aghdaee, M.M. Bahar, R. Raeisossadati, M.M. Forghanifard, S.R.E.A. Bakhtiari, A. Baradaran and M.R. Abbaszadegan
Microsatellite instability in sporadic colorectal cancer patients was assessed, and the clinicopathological associations were evaluated in northeastern Iran, which is a high-risk region for gastrointestinal malignancies. Microsatellite instability (MSI)status of tumoral tissue, compared to normal tissue, was assessed with a st.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.4
- DOI:
- 10.4238/2011.December.14.4
Vascular endothelial growth factor gene polymorphisms and colorectal cancer risk: a meta-analysis
Authors: L.P. Zhou, H. Luan, X.H. Dong, G.J. Jin, D.L. Man and H. Shang
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.13
- DOI:
- 10.4238/2011.October.31.13
Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis.
Authors: C. Wang, D.Z. Hu and J.Z. Liu
To explore the potential cause of colorectal cancer metastasis, gene expression profiles, GSE21510, and miRNA expression profiles, GSE48074, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes in metastatic colorectal and non metastatic colorectal cancer compared with the normal samples were identified via the limma p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.19
- DOI:
- 10.4238/2015.May.22.19
Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis
Authors: C. Wang D.Z. Hu and J.Z. Liu
To explore the potential cause of colorectal cancer metastasis, gene expression profiles, GSE21510, and miRNA expression profiles, GSE48074, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes in metastatic colorectal and non metastatic colorectal cancer compared with the normal samples were identified via the limma p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.19
- DOI:
- 10.4238/2015.May.22.19
Serum level of endothelial cell-specific molecule-1 and prognosis of colorectal cancer.
Authors: H. Jiang, X.G. Fu and Y.T. Chen
We evaluated the clinical significance and explored the prognostic value of serum endothelial cell-specific molecule-1 (ESM-1) expression in colorectal cancer (CRC) in a Chinese population. Serum samples were obtained from 89 CRC patients undergoing surgical treatment and 90 healthy volunteers (control group). ESM-1 levels in serum samples from CRC patien.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.3
- DOI:
- 10.4238/2015.May.25.3
Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population
Authors: T.P. Lau, A.C. Roslani, L.H. Lian, P.C. Lee, I. Hilmi, K.L. Goh and K.H. Chua
Growth factors are polypeptides that are critical for the initiation, progression, and metastasis of cancer. Most tumor cells are capable of synthesizing particular growth factors leading to constitutive pathway activation in these cells through autocrine signaling. Epidermal growth factor (EGF) is a potent mitogenic peptide t.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.9
- DOI:
- 10.4238/2014.July.25.9
Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population
Authors: H. Li, W.L. Xu, H.L. Shen, Q.Y. Chen, L.L. Hui, L.L. Long and X.L. Zhu
Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a po.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.8
- DOI:
- 10.4238/2011.December.14.8
Expression changes in epithelial cell adhesion molecule during colorectal cancer tumorigenesis
Authors: X.B. Chai, R.F. Song and F. Xu
We investigated the relationship between the expression of epithelial cell adhesion molecule (EpCAM) and the occurrence and development of colon cancer. Fifty colon cancer tissues and adjacent normal tissues were collected, while 40 normal intestinal mucosa tissues were collected as the blank group. EpCAM expression was detected by immunohistochemistry an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.6
- DOI:
- 10.4238/2015.July.13.6