Colorectal Cancer
High methylation of the SEPT9 gene in Chinese colorectal cancer patients
Authors: X.L. Su, Y.F. Wang, S.J. Li, F. Zhang and H.W. Cui
Methylation of the septin 9 gene (SEPT9) occurs in higher frequency in colorectal cancer (CRC) compared to control samples, which suggests that SEPT9 methylation is a useful biomarker for screening CRC. However, the methylation status of SEPT9 in Chinese CRC patients is scarcely reported. In the present study, SEPT9 methylatio.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.17.5
- DOI:
- 10.4238/2014.January.17.5
NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans
Authors: Q. Zhang, H.W. Fan, J.Z. Zhang, Y.M. Wang and H.J. Xing
Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.17
- DOI:
- 10.4238/2015.October.29.17
RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer
Authors: S. SuÃ?¡rez-Villanueva, M.L. Ayala-Madrigal, J. Peregrina-Sandoval, N. MacÃ?Âas-GÃ?³mez, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz-Mendoza, J.M. Moreno-Ortiz, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, E. Cabrales and M. GutiÃ?©rrez-Angulo
We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC). Genomic DNA samples were obtained from the peripheral blood of 176 Mexican patients with CRC at diagnosis and from 195 individuals that formed the control group. The polymorphisms were detected b.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.28
- DOI:
- 10.4238/2015.November.30.28
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes
Authors: J. Zekri, A. Al-Shehri, M. Mahrous, S. Al-Rehaily, T. Darwish, S. Bassi, H. El Taani, A. Al Zahrani, S. Elsamany, J. Al-Maghrabi and B.B. Sadiq
Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019369
- DOI:
- 10.4238/gmr16019369
Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer
Authors: D.H. Xiu, Y. Chen, L. Liu, H.S. Yang and G.F. Liu
Kruppel-like factors (KLFs) are a group of transcriptional regulators that have recently been identified to exhibit tumor-suppressive function against various gastrointestinal cancers. The present study aims to investigate the expression patterns and prognostic value of KLF-4 in colorectal cancers (CRCs). KLF-4 levels in CRC t.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019272
- DOI:
- 10.4238/gmr16019272
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer
Authors: T.D. Silva A.V. Felipe C.A.M. Pimenta K. Bar�£o N.M. Forones
We investigated a possible association between alcoholism, cigarette smoking, obesity and CYP2E1 RsaI and 96-bp insertion genetic polymorphisms with risk for colorectal cancer (CRC). Patients with CRC (70 women and 61 men) were matched for gender and age to 206 healthy controls. The mean age of the two groups was 62 years. Meat intake, cigarette smoking a.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.2
- DOI:
- 10.4238/2012.September.3.2
Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk
Authors: Y.M. Zhang X.C. Zhou Z. Xu C.J. Tang
In order to make a comprehensive assessment of the potential association between two genetic variants in the IL-10 gene promoter, -1082 A>G (rs1800896) and -592 C>A (rs1800872), and colorectal cancer (CRC) risk, we conduced a meta-analysis of seven epidemiological studies, which included 1469 colorectal cancer cases and 2566 controls. Neither of the.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.25.7
- DOI:
- 10.4238/2012.September.25.7
Somatic copy-neutral loss of heterozygosity and copy number abnormalities in Malaysian sporadic colorectal carcinoma patients
Authors: Y.Y. Yam B.P. Hoh N.H. Othman S. Hassan M.M. Yahya Z. Zakaria R. Ankathil
Colorectal cancer is one of the most common cancers in many countries, including Malaysia. The accumulation of genomic alterations is an important feature of colorectal carcinogenesis. A better understanding of the molecular events underlying the stages of colorectal carcinogenesis might be helpful in the detection and management of the disease. We used a.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.7.1
- DOI:
- 10.4238/2013.February.7.1
5-Fluorouracil induces apoptosis of colorectal cancer cells
Authors: J.T. Zhang1, W.L. Zhou2, C. He3, T. Liu1, C.Y. Li1 and L. Wang1
5-Fluorouracil (5-FU) is widely used in chemotherapy for treatment of colorectal cancer. Leucine-rich repeat-containing G protein-coupled receptor (LGR) is known to participate in the occurrence and development of breast cancer by regulating the rebirth of tumor vessels. This study aimed to explore the proliferation and apoptosis of HCT116 colorectal canc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017326
- DOI:
- 10.4238/gmr.15017326
Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer
Authors: M.A. Rosales-Reynoso, L.I. Wence-Chavez, A.R. Arredondo-Valdez,S. Dumois-Petersen, P. Barros-NÃ?ºÃ?±ez, M.P. Gallegos-Arreola, S.E. Flores-MartÃ?Ânez and J. SÃ?¡nchez-Corona
PPARD encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. Accumulated evidence suggests that the polymorphism rs2016520 in PPARD is associated with lipid metabolism, obesity, metab.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019324
- DOI:
- 10.4238/gmr16019324