Colorectal Cancer
Effect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population
Authors: R. RamÃ?Ârez-RamÃ?Ârez, M. GutiÃ?©rrez-Angulo, M.T. MagaÃ?±a, J.M. Moreno-Ortiz, M. Partida-PÃ?©rez, R. MuÃ?±iz-Mendoza, J. Peregrina-Sandoval, A.S. SuÃ?¡rez-Villanueva, M. Centeno-Flores, V.M. Maciel-GutiÃ?©rrez, E. Cabrales-Vazquez and M.L. Ayala-Madrigal
The ZNF217 gene, a potential oncogene amplified and overexpressed in several cancers including colorectal cancer (CRC), acts as a transcription factor that activates or represses target genes. The polymorphisms rs16998248 (T>A) and rs35720349 (C>T) in coronary artery disease have been associated with reduced expression of ZNF217. In this study, we analyzed t.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.9
- DOI:
- 10.4238/2015.January.23.9
Clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) in colorectal cancer: a meta-analysis
Authors: Y. Wang and T.T. Zeng
Growing evidence has implicated that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in a spectrum of human cancers. Several observational studies from different parts of the world have been devoted to elucidate the clinical relationship between NGAL and colorectal cancer. This meta-analysis aimed to explore the.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.21.11
- DOI:
- 10.4238/2014.February.21.11
NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer
Authors: T.P. Lau, A.C. Roslani, L.H. Lian, P.C. Lee, I. Hilmi, K.L. Goh and K.H. Chua
Colorectal cancer (CRC) is one of the most common types of cancer in both developed and developing countries. This disease is triggered by and progresses via the sequential accumulation of multiple genetic alterations. In addition, the interaction between low-penetrance genes and environmental factors can also increase the ris.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.19.3
- DOI:
- 10.4238/2014.March.19.3
Association between serum angiopoietin-2 concentration and clinicopathological parameters in patients with colorectal cancer
Authors: Z.Q. Wang,X.L. Sun,H.L. Su,X.F. Liu,Y.J. Xuan,S.Q. Yu
We examined the expression of angiopoietin-2 in serum samples from patients diagnosed with colorectal cancer and healthy volunteers and investigated the feasibility of using angiopoietin-2 as a potential diagnostic colorectal cancer biomarker. Enzyme-linked immunosorbent assays were used to measure the levels of angiopoietin-2.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.5
- DOI:
- 10.4238/2015.December.1.5
Correlation between non-metastatic protein 23 expression and clinicopathological features of colorectal cancer in Asians
Authors: J.W. Fu, X.Q. Chu
The current meta-analysis was performed to investigate the association between non-metastatic protein 23 (NM23) expression, tumor pathology, and disease prognosis in colorectal cancer (CRC) among Asians. English and Chinese language-based electronic databases (e.g., PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wan.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.11
- DOI:
- 10.4238/2015.December.1.11
Prospective analysis of KRAS wild-type patients with metastatic colorectal cancer using cetuximab plus FOLFIRI or FOLFOX4 treatment regimens
Authors: M.Y. Huang, M.J. Chen, H.L. Tsai, C.H. Kuo, C.J. Ma, M.F. Hou, S.C. Chuang, S.R. Lin and J.Y. Wang
Cetuximab, a monoclonal antibody targeting epidermal growth factor receptor, has proven to be efficient in the treatment of metastatic colorectal cancer. We made a prospective study of the efficacy and toxicities of cetuximab-combination first-line (FOLFOX4) versus second/third-line (FOLFIRI) chemotherapy in 98 KRAS wildtype p.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.3.4
- DOI:
- 10.4238/2011.October.3.4
Association of ADH1B Arg47His and ALDH2 Glu487Lys polymorphisms with risk of colorectal cancer and their interaction with environmental factors in a Chinese population
Authors: Q. Zhong, R.R. Wu and Z.M. Zeng
Human colorectal cancer (CRC) is a major worldwide health concern, and its development has been shown to be associated with alcohol intake. We carried out a study to investigate the effect of the ADH1B Arg47His and ALDH2 Glu487Lys genetic polymorphisms and their interaction with alcohol consumption on development of CRC. Between March 2013 and May 2015, a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038682
- DOI:
- 10.4238/gmr.15038682
Long interspersed nucleotide acid element-1 ORF-1 protein promotes proliferation and invasion of human colorectal cancer LoVo cells through enhancing ETS-1 activity
Authors: M.Y. Li, M. Zhu, F. Feng, F.Y. Cai, K.C. Fan, H. Jiang, Z.Q. Wang and E.Q. Linghu
The human proto-oncogene long interspersed nucleotide acid element-1 (LINE-1) open reading frame-1 protein (ORF-1p) is involved in the progress of several cancers. The transcription factor ETS-1 can mediate the transcription of some downstream genes that play specific roles in the regulation of cancerous cell invasion and meta.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.14.13
- DOI:
- 10.4238/2014.April.14.13
Prevention of DNA damage and anticarcinogenic activity of Activia�® in a preclinical model
Authors: S.M.A. Limeiras, F.M. Ogo, L.A.L. Genez, C.M. Carreira,E.J.T. Oliveira, L.R. Pessatto, S.C. Neves, J.R. Pesarini, L.C. Schweich, R.A. Silva, W.B. Cantero, A.C.M.B. Antoniolli-Silva, R.J. Oliveira
Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria comb.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019492
- DOI:
- 10.4238/gmr16019492
Enhanced expression and significance of glycosylphosphatidylinositol anchor attachment protein 1 in colorectal cancer
Authors: G. Chen, S.Y. Li, H.Y. Cai and F.Y. Zuo
The aim of this study was to investigate the expression of glycosylphosphatidylinositol anchor attachment protein 1 (GPAA1) and its significance in patients with colorectal cancer. Fifty-two patients with primary colorectal cancer were included in this study. GPAA1 expression was detected by immunohistochemistry, reverse trans.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.19
- DOI:
- 10.4238/2014.January.21.19