Table of Contents | Genet. Mol. Res.2016(1)
Mutations in WT1 in boys with sporadic isolated steroid-resistant nephrotic syndrome
Authors: Y. Yang1,2,3*, F. Zhao1,2,3*, X. Tu4 and Z. Yu1,2,3
Mutations in the Wilms’ tumor gene, WT1, can lead to syndromic steroid-resistant nephrotic syndrome and isolated steroid-resistant nephrotic syndrome. WT1 mutations have been identified in the majority of children with Denys-Drash or Frasier syndrome. WT1 mutations have not previously been identified in boys with sporadic isolated steroid-resistant .. Read More»
Genet. Mol. Res. 15(1): gmr.15017559
DOI: 10.4238/gmr.15017559
Prognostic significance of long non-coding RNA MALAT-1 in various human carcinomas: a meta-analysis
Authors: J. Wang1*, A.M. Xu1*, J.Y. Zhang1*, X.M. He2, Y.S. Pan1, G. Cheng1, C. Qin1,L.X. Hua1 and Z.J. Wang1
The long non-coding RNA MALAT-1 plays an important role in cancer prognosis. The present research aimed to elucidate its precise predictive value in various human carcinomas. A quantitative meta-analysis was performed by searching PubMed, Embase, Web of Science, and Cochrane Library (most recently, January 2015) databases, and extracting data from studies.. Read More»
Genet. Mol. Res. 15(1): gmr.15017433
DOI: 10.4238/gmr.15017433
E2F, HSF2, and miR-26 in thyroid carcinoma: bioinformatic analysis of RNA-sequencing data
Authors: J.C. Lu and Y.P. Zhang
In this study, we examined the molecular mechanism of thyroid carcinoma (THCA) using bioinformatics. RNA-sequencing data of THCA (N = 498) and normal thyroid tissue (N = 59) were downloaded from The Cancer Genome Atlas. Next, gene expression levels were calculated using the TCC package and differentially expressed genes (DEGs) were identified using the ed.. Read More»
Genet. Mol. Res. 15(1): gmr.15017576
DOI: 10.4238/gmr.15017576
Whole-exome sequencing reveals a novel COL2A1 mutation in a patient with spondyloÃ?Âepiphyseal dysplasia congenita
Authors: Sangsin1,2,3,4, C. Srichomthong3,4, M. Pongpanich5,6, K. Suphapeetiporn3,4 and V. Shotelersuk3,4
Skeletal dysplasia is a group of disorders with more than 450 entities, many of which cannot be differentiated, especially during infancy, but could lead to different clinical courses and prognoses. In this study, we have described a case of a Thai infant with short stature, flat face, pectus carinatum, indirect inguinal hernia, platyspondyly, and general.. Read More»
Genet. Mol. Res. 15(1): gmr.15017624
DOI: 10.4238/gmr.15017624
Analysis of imprinted messenger RNA expression in deceased transgenic cloned goats
Authors: R.X. Jia, Z.R. Zhou, G.M. Zhang, L.Z. Wang, Y.X. Fan, Y.J. Wan, Y.L. Zhang,Z.Y. Wang and F. Wang
Genomic imprinting is an important epigenetic mechanism that has vital effects on fetal growth and development. We observed the differences in four tissues (heart, spleen, liver, and kidney) from dead transgenic cloned goats using hematoxylin and eosin (H&E) staining. Eight imprinted genes in the tissues of dead transgenic cloned and normal goats were.. Read More»
Genet. Mol. Res. 15(1): gmr.15017455
DOI: 10.4238/gmr.15017455
Homology modeling and molecular dynamics of �²-defensin II variants in Amazonian sheep
Authors: A.S. Siqueira1, B.B. de Souza2, A.R.J. Lima1, E.M. Barbosa2, J.S.N. Azevedo3, E.C. Gon�§alves1 and E. Silva Filho2
β-defensins are capable of creating pores in the bacterial membrane. In this study, we aim to determine the structure of 3 different sheep β-defensin 2 (SBD-2) sequences by molecular modeling. A herd of 47 sheep from the Centre for Ovine and Caprine Research of Pará was selected for this investigation. The AA, AG, and GG alleles were foun.. Read More»
Genet. Mol. Res. 15(1): gmr.15017469
DOI: 10.4238/gmr.15017469
Regulation of bolting and identification of the �±-tubulin gene family in Brassica rapa L. ssp pekinensis
Authors: Y.W. Zhang1,2, D. Jin1, C. Xu1, L. Zhang1, M.H. Guo1 and Z.Y. Fang3
Microtubules are important components of eukaryotic cells, and they play vital roles in cell morphogenesis, carrying of signaling molecules, transport of materials, and establishing the cell polarity. During bolting of biennial plants, cell division and elongation are involved, and cell elongation inevitably involves the microtubules arrangement and expre.. Read More»
Genet. Mol. Res. 15(1): gmr.15017507
DOI: 10.4238/gmr.15017507
Exhaustive search for conservation networks of populations representing genetic diversity
Authors: J.A.F. Diniz-Filho1, J.V.B.P.L. Diniz2 and M.P.C. Telles3
Conservation strategies routinely use optimization methods to identify the smallest number of units required to represent a set of features that need to be conserved, including biomes, species, and populations. In this study, we provide R scripts to facilitate exhaustive search for solutions that represent all of the alleles in networks with the smallest .. Read More»
Genet. Mol. Res. 15(1): gmr.15017525
DOI: 10.4238/gmr.15017525