Table of Contents | Genet. Mol. Res.2013(2)
Forced expression of OCT4 influences the expression of pluripotent genes in human mesenchymal stem cells and fibroblasts
Authors: C.S. Palma, M.A. Tannous, T.M. Malta, E.M.S. Russo, D.T. Covas and V. Pican�§o-Castro
Genetic reprogramming of adult cells to generate induced pluripotent stem (iPS) cells is a new and important step in sidestepping some of the ethical issues and risks involved in the use of embryonic stem cells. iPS cells can be generated by introduction of transcription factors, such as OCT4, SOX2, KLF4, and CMYC. iPS cells resemble embryonic stem cells .. Read More»
Genet. Mol. Res. 12(2): 2013.April.2.22
DOI: 10.4238/2013.April.2.22
Correlation of tumor relapse and elevated expression of survivin and vascular endothelial growth factor in superficial bladder transitional cell carcinoma
Authors: Y.W. Sun, Q. Xuan, Q.A. Shu, S.S. Wu, H. Chen, J. Xiao, P. Xiang, Y.P. Zhu, F.L. Wang and S.T. Zhao
Survivin and vascular endothelial growth factor (VEGF) are newly discovered tumor markers closely correlated with bladder cancer. We analyzed the expression of survivin and VEGF in paraffin-embedded tumor tissues from 78 patients with bladder transitional cell carcinoma (BTCC) using an immunohistochemistry method. Normal bladder mucosae from 10 non-BTCC c.. Read More»
Genet. Mol. Res. 12(2): 2013.April.2.21
DOI: 10.4238/2013.April.2.21
Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies
Authors: Y.Z. Li, L.J. Wang, X. Li, S.L. Li, J.L. Wang, Z.H. Wu, L. Gong and X.D. Zhang
Endometriosis is a chronic gynecological disease defined as the presence of the endometrium outside the uterine cavity. Endometriosis is a multifactorial and polygenic disease in which angiogenesis may be implicated. Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF). Many studies have reported that.. Read More»
Genet. Mol. Res. 12(2): 2013.April.2.20
DOI: 10.4238/2013.April.2.20
Sequence analysis of the regulatory region of the TNF-RII gene in Polish Holstein-Friesian cows
Authors: A. Stachura, E. Kaczmarczyk and B. BojarojÃ?Â?-Nosowicz
Tumor necrosis factor receptor type II (TNF-RII) is a surface glycoprotein that can form a complex with TNF-α and participate in the body’s immune response. Functions of TNF-RII are impaired in the pathogenesis of viral diseases. We analyzed sequences in the regulatory region of the TNF-RII gene in cattle. An attempt was also made to identify .. Read More»
Genet. Mol. Res. 12(2): 2013.April.2.19
DOI: 10.4238/2013.April.2.19
Nucleotide mismatches of foot-and-mouth disease virus during replication
Authors: Y.B. Ma, C.X. Hao and H.Y. Chang
As there is a lack of error correction mechanisms during RNA replication, foot-and-mouth disease virus (FMDV) has a very high mismatch rate, which leads to a high mutation rate, in the range of 10-3 to 10-5 per nucleotide site per genome replication. We examined the nucleotide mismatch of FMDV during replication, based on the whole genomes of the 7 seroty.. Read More»
Genet. Mol. Res. 12(2): 2013.April.2.18
DOI: 10.4238/2013.April.2.18
MicroRNA-181b expression in prostate cancer tissues and its influence on the biological behavior of the prostate cancer cell line PC-3
Authors: L. He, H. Yao, L.H. Fan, L. Liu, S. Qiu, X. Li, J.P. Gao and C.Q. Hao
We examined microRNA-181b (miRNA) expression in prostate cancer tissues and its effect on the prostate cancer cell line PC-3. Tissues from 27 cases of prostate cancer and 30 samples of normal human prostate were collected by surgical removal. Total miRNA was extracted, and the relative expression of miR-181b was quantified using RT-PCR. miR-181b ASO was t.. Read More»
Genet. Mol. Res. 12(2): 2013.April.2.17
DOI: 10.4238/2013.April.2.17
The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction
Authors: V.C. Fernandes, S.I.V. Pereira, J. Coppede, J.S. Martins, W.F. Rizo, R.O. Beleboni, M. Marins, P.S. Pereira, A.M.S. Pereira and A.L. Fachin
Cancer has become the leading cause of death in developing countries due to increased life expectancy of the population and changes in lifestyle. Studies on active principles of plant have motivated researchers to develop new antitumor agents that are specific and effective for treatment of neoplasms. Kaurane diterpenes are considered important compounds .. Read More»
Genet. Mol. Res. 12(2): 2013.April.2.16
DOI: 10.4238/2013.April.2.16
Significance of Bcl10 gene mutations in the clinical diagnosis of MALT-type ocular adnexal lymphoma in the Chinese population
Authors: J. Zhu, R.L. Wei, Y.L. Pi and Q. Guo
We investigated the expression of Bcl10 gene mutations in mucosa-associated lymphoid tissue-type ocular adnexal lymphoma (OAL), atypical lymphoid hyperplasia (ALH), and reactive lymphoid hyperplasia (RLH) in the Chinese population and its role in clinical diagnosis and pathogenesis. Forty-three samples were collected during patient surgeries. Pathological.. Read More»
Genet. Mol. Res. 12(2): 2013.April.12.6
DOI: 10.4238/2013.April.12.6