Table of Contents | Genet. Mol. Res.2013(2)
A systematic review of the intergenerational aspects and the diverse genetic profiles of Huntington��?s disease
Authors: L.A. Agostinho, S.R. dos Santos, R.M.P. Alvarenga and C.L.A. Paiva
Huntington’s disease (HD) is a rare progressive and fatal neurogenetic degenerative disease, characterized by movement and personality disorders and by progressive dementia. Its prevalence varies by ethnic origin and different genetic profiles predisposing individuals to HD in each population. The prevalence of HD is 5-10 per 100,000 individuals in .. Read More»
Genet. Mol. Res. 12(2): 2013.June.13.6
DOI: 10.4238/2013.June.13.6
Analysis of genetic diversity among Chinese wild Vitis species revealed with SSR and SRAP markers
Authors: Z.B. Jing, X.P. Wang and J.M. Cheng
The genetic diversity among 80 Vitis materials including 62 indigenous accessions of 17 wild Vitis species in China and 7 interspecific hybrids, 10 V. vinifera L. cultivars, and 1 V. riparia Michaux were evaluated by simple sequence repeat and sequence-related amplified polymorphism markers. A total of 10 simple sequence repeat primers and 11 sequence-rel.. Read More»
Genet. Mol. Res. 12(2): 2013.June.13.5
DOI: 10.4238/2013.June.13.5
Characterization of microRNAs from goat (Capra hircus) by Solexa deep-sequencing technology
Authors: Y.H. Ling, J.P. Ding, X.D. Zhang, L.J. Wang, Y.H. Zhang, Y.S. Li, Z.J. Zhang and X.R. Zhang
MicroRNAs (miRNAs) are an important class of small noncoding RNAs that are highly conserved in plants and animals. Many miRNAs are known to mediate a myriad of cell processes, including proliferation and differentiation, via the regulation of some transcription and signaling factors, which are closely related to muscle development and disease. In this stu.. Read More»
Genet. Mol. Res. 12(2): 2013.June.13.4
DOI: 10.4238/2013.June.13.4
DNA and RNA polymerase activity in a Moniliophthora perniciosa mitochondrial plasmid and self-defense against oxidative stress
Authors: B.S. Andrade, C. Villela-Dias, D.S. Gomes, F. Micheli and A. G�?³es-Neto
Moniliophthora perniciosa (Stahel) Aime and Phillips-Mora is a hemibiotrophic basidiomycete (Agaricales, Tricholomataceae) that causes witches’ broom disease in cocoa (Theobroma cacao L.). This pathogen carries a stable integrated invertron-type linear plasmid in its mitochondrial genome that encodes viral-like DNA and RNA polymerases related to fun.. Read More»
Genet. Mol. Res. 12(2): 2013.June.13.3
DOI: 10.4238/2013.June.13.3
Genetic diversity of Vriesea cacuminis (Bromeliaceae): an endangered and endemic Brazilian species
Authors: P.C.C. Ribeiro, L.C. Pinheiro, R. Domingues, R.C. Forzza, M.A. Machado and L.F. Viccini
Data about the genetic structure can help to understand the evolutionary process of natural populations as well as to drive strategies of conservation. Vriesea cacuminis, an endemic Brazilian Bromeliad, has been found in 2 areas of Minas Gerais State. One is a legal preservation unit (Ibitipoca State Park) and the other an unprotected area (Serra Negra). .. Read More»
Genet. Mol. Res. 12(2): 2013.June.13.2
DOI: 10.4238/2013.June.13.2
Vascular endothelial growth factor +936C/T polymorphism and cancer risk in Asians: a meta-analysis
Authors: X.L. Liu, Q.F. Yang and B.H. Kong
Vascular endothelial growth factor (VEGF), the most important regulator of angiogenesis and vascular permeability, is involved in various steps of carcinogenesis. The +936C/T polymorphism of the VEGF gene has been reported to affect the VEGF protein level and to be related to the susceptibility of cancer. However, the results of published studies, as well.. Read More»
Genet. Mol. Res. 12(2): 2013.June.13.1
DOI: 10.4238/2013.June.13.1
Meta-analysis demonstrates lack of a relationship between XRCC1-399 gene polymorphisms and susceptibility to hepatocellular carcinoma
Authors: X.Y. Zeng, J.M. Huang, J.W. Xu, Y. Xu, H.P. Yu, L. Ji and X.Q. Qiu1,
XRCC1-399 allele polymorphisms have been reported to be associated with susceptibility to hepatocellular carcinoma (HCC), but the conclusions of the various studies have been inconsistent. We conducted a meta-analysis of available studies to determine whether XRCC1-399 alleles influence susceptibility to hepatocellular carcinoma. We searched English-langu.. Read More»
Genet. Mol. Res. 12(2): 2013.March.15.5
DOI: 10.4238/2013.March.15.5
Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression
Authors: H. He, J. Chen, W.P. Xie, S. Cao, H.Y. Hu, L.Q. Yang and B. Gong
Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain in chronic cancer patients. We applied ketamine to breast cancer cell line MDA-MB-231 to detect the effect of treatment and molecular mechanisms involved. We found that ketamine can upregulate the level of anti-apoptosis protein Bcl-2, which promotes br.. Read More»
Genet. Mol. Res. 12(2): 2013.January.4.7
DOI: 10.4238/2013.January.4.7