X.L. Wang
Association of monocyte chemoattractant protein-1 rs1024611 and telomerase rs2736100 polymorphisms with susceptibility to pulmonary tuberculosis in Han Chinese population
Pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis infection and accumulated evidence reveals the genetic context of its infection phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant is shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In addition, telomerase plays a key role in .. Read More»
Genet. Mol. Res. 16(3): gmr16039697
DOI: 10.4238/gmr16039697
Methylation analysis of CXCR1 in mammary gland tissue of cows with mastitis induced by Staphylococcus aureus
Mastitis is the most important disease in the global dairy industry, and causes large economic losses. Staphylococcus aureus is one of most common pathogens that cause bovine mastitis. CXCR1 has been implicated as a prospective genetic marker for mastitis resistance in dairy cows; CXCR1 expression significantly increases when cows have mastitis. To investigate the m.. Read More»
Genet. Mol. Res. 14(4): 2015.October.19.4
DOI: 10.4238/2015.October.19.4
Prognostic significance of tumor-associated macrophage infiltration in gastric cancer: a meta-analysis
Tumor-associated macrophages (TAMs), which play a crucial role in the tumor microenvironment, can be divided into M1 and M2 phenotypes, these phenotypes may exert opposite effects on the prognoses of patients with gastric cancer (GC). The association between TAMs and GC is contentious. Thus, a meta-analysis of 12 studies (incorporating 1388 patients) retrieved from .. Read More»
Genet. Mol. Res. 15(4): gmr15049040
DOI: 10.4238/gmr15049040
Study on serum proteomic features in patients with and without recurrence or metastasis after surgical resection of esophageal carcinoma
The purpose of this study was to identify specific biomarkers for recurrence or metastasis of esophageal carcinoma in serum of patients subjected to esophagectomy. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) combined with IMAC-Cu2+ ProteinChip array were performed for the serum protein profiling in patients after surg.. Read More»
Genet. Mol. Res. 13(1): 2014.January.21.23
DOI: 10.4238/2014.January.21.23
Proteomic analysis revealed the altered kidney protein profile of a Cyld knockout mouse model
The aim of this study was to compare the proteomics pattern of the kidneys from Cyld knockout mice with that from normal mouse kidneys and establish a preliminary understanding of the role of Cyld in the kidney. Proteins from the kidneys of knockout Cyld mice and wild-type mice were extracted, isobaric tags for relative and absolute quantitation (iTRAQ) was performed, and the proteomics pattern.. Read More»
Genet. Mol. Res. 14(2): 2015.June.1.14
DOI: 10.4238/2015.June.1.14
Respiratory chain complex III deficiency in patients with tRNA-leu mutation
The aim of this study was to investigate the clinical and genetic profiles of mitochondrial disease resulting from deficiencies in the respiratory chain complex III. Three patients, aged between 8 months and 12 years, were recruited for this study. The activities of mitochondrial respiratory chain complexes in the peripheral leucocytes were spectrophotometrically measured. The entire mitochondr.. Read More»
Genet. Mol. Res. 14(4): 2015.December.28.12
DOI: 10.4238/2015.December.28.12
Differential expression of peroxisome proliferator-activated receptor γ, fatty acid synthase, and hormone-sensitive lipase in fat-tailed and thin-tailed sheep breeds
Tail fat content affects meat quality, and it varies in different sheep breeds. Theoretically, lipid metabolism contributes to variation in tail fat content. Tail length, tail width, and tail girth were measured in live Tong sheep (with both short fat tail and long fat tail), Shaanbei fine wool sheep (long thin tail), Tan sheep (short fat tail), Kazakh sheep (hip fa.. Read More»
Genet. Mol. Res. 14(4): 2015.December.1.14
DOI: 10.4238/2015.December.1.14
Differential expression of peroxisome proliferator-activated receptor γ, fatty acid synthase, and hormone-sensitive lipase in fat-tailed and thin-tailed sheep breeds
Tail fat content affects meat quality, and it varies in different sheep breeds. Theoretically, lipid metabolism contributes to variation in tail fat content. Tail length, tail width, and tail girth were measured in live Tong sheep (with both short fat tail and long fat tail), Shaanbei fine wool sheep (long thin tail), Tan sheep (short fat tail), Kazakh sheep (hip fa.. Read More»
Genet. Mol. Res. 14(4):
Co-evolution of genomic islands and their bacterial hosts revealed through phylogenetic analyses of 17 groups of homologous genomic islands
Horizontal gene transfer is an important mechanism for the evolution of microbial genomes, and many horizontal gene transfer events are facilitated by genomic islands (GIs). Until now, few reports have provided evidence for the co-evolution of horizontally transferred genes and their hosts. We obtained 17 groups of homologous GIs, all of which appear in 8 or more bacterial strains of the same s.. Read More»
Genet. Mol. Res. 11(4): 2012.October.15.5
DOI: 10.4238/2012.October.15.5
A female patient with normosmic idiopathic hypogonadotropic hypogonadism carrying a novel mutation in FGFR1.
Mutations in the fibroblast growth factor receptor 1 gene (FGFR1) have been reported in patients with Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Here, we report an nIHH patient with a novel mutation in FGFR1. The patient was a 19-year-old female who presented the nIHH phenotype with primary amenorrhea, cleft lip and palate, mixed hearing disorders, and skel.. Read More»
Genet. Mol. Res. 13(4):
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