C. Sun
Association of monocyte chemoattractant protein-1 rs1024611 and telomerase rs2736100 polymorphisms with susceptibility to pulmonary tuberculosis in Han Chinese population
Pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis infection and accumulated evidence reveals the genetic context of its infection phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant is shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In addition, telomerase plays a key role in .. Read More»
Genet. Mol. Res. 16(3): gmr16039697
DOI: 10.4238/gmr16039697
Efficacy of combined hepatitis B immunoglobulin and hepatitis B vaccine in blocking father-infant transmission of hepatitis B viral infection
The aim of this study was to examine the efficacy of combined immunization of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine (HBVac) in blocking father-infant transmission of hepatitis B virus (HBV). Newborns positive at birth for blood HBV surface antigen (HBsAg) and/or HBV DNA were selected and immunized with HBIG combination HBVac. At 7 months, HBV markers and HBV DNA of each neon.. Read More»
Genet. Mol. Res. 14(2): 2015.May.4.24
DOI: 10.4238/2015.May.4.24
Single nucleotide polymorphism analysis of exons 3 and 4 of IGF-1 gene in pigs
The IGF-1 gene has been implicated as a candidate gene for the regulation of pig growth traits. We analyzed exons 3 and 4 of IGF-1 gene polymorphisms of the Banna mini-pig (28), the Tibetan mini-pig (30), the Junmu pig (55), and L. Yorkshire species (50) using PCR-SSCP. Three genotypes in exon 3 and 6 genotypes in exon 4 were observed, among which, one single nucleo.. Read More»
Genet. Mol. Res. 10(3): vol10-3gmr1328
DOI: 10.4238/vol10-3gmr1328
Construction of suppressor of cytokine signaling 2 (SOCS2) adenoviral overexpression vector and its impact on growth hormone- induced lipolysis in swine primary adipocytes
We investigated the effect of overexpression suppressor of cytokine signaling 2 (SOCS2) on lipolysis in swine primary adipocytes (pAd) induced by growth hormone (GH). We constructed pAd-SOCS2 adenoviral overexpression vectors to infect HEK293 cells for virus packaging and propagation. Cultured swine primary adipocytes were infected with virus particles; after 48 h the infected adipocytes were t.. Read More»
Genet. Mol. Res. 12(2): 2013.January.9.2
DOI: 10.4238/2013.January.9.2
Proteomic analysis revealed the altered kidney protein profile of a Cyld knockout mouse model
The aim of this study was to compare the proteomics pattern of the kidneys from Cyld knockout mice with that from normal mouse kidneys and establish a preliminary understanding of the role of Cyld in the kidney. Proteins from the kidneys of knockout Cyld mice and wild-type mice were extracted, isobaric tags for relative and absolute quantitation (iTRAQ) was performed, and the proteomics pattern.. Read More»
Genet. Mol. Res. 14(2): 2015.June.1.14
DOI: 10.4238/2015.June.1.14
miR-146a and miR-196a2 polymorphisms in ovarian cancer risk
We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of miR-146a and miR-196a2 was accomplished by.. Read More»
Genet. Mol. Res. 15(3): gmr.15038468
DOI: 10.4238/gmr.15038468
Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women
We carried out a case-control study to evaluate the role of MMP-9 -1562 C/T (rs3918242) genetic polymorphism in the risk of pre-eclampsia in Chinese pregnant women. Between March 2013 and January 2015, 107 pregnant women with pre-eclampsia were recruited from the Second Affiliated Hospital of Zhengzhou University. Genotyping of MMP-9 was carried out using polymerase chain reaction-restriction f.. Read More»
Genet. Mol. Res. 15(3): gmr.15038355
DOI: 10.4238/gmr.15038355
Efficacy and safety of nucleoside analogues in preventing vertical transmission of the hepatitis B virus from father to infant
We examined the efficacy and safety of nucleoside analogues in preventing the vertical transmission of hepatitis B virus (HBV) from father to infant. We included 201 patients who visited the liver clinic of our hospital. The patients were positive for HBV surface antigen (HBsAg), HBeAg, anti-HBc, and HBV DNA; 189 patients (94%) had abnormal liver function. In all co.. Read More»
Genet. Mol. Res. 14(4): 2015.December.1.4
DOI: 10.4238/2015.December.1.4
Effects of the balance between type 1 and type 2 T helper cells on ovarian cancer
The balance between type 1 and type 2 T helper cells (the Th1-Th2 balance) is closely correlated with cancer, but the correlation in ovarian cancer remains unconfirmed. We investigated the Th1-Th2 balance for the diagnosis, treatment, and prognostic evaluation of ovarian cancer. Fifty healthy subjects and 50 ovarian cancer patients were recruited. The levels of vari.. Read More»
Genet. Mol. Res. 15(2): gmr.15027936
DOI: 10.4238/gmr.15027936
Methylation-sensitive amplified polymorphism-based genome-wide analysis of cytosine methylation profiles in Nicotiana tabacum cultivars
This study aimed to investigate cytosine methylation profiles in different tobacco (Nicotiana tabacum) cultivars grown in China. Methylation-sensitive amplified polymorphism was used to analyze genome-wide global methylation profiles in four tobacco cultivars (Yunyan 85, NC89, K326, and Yunyan 87). Amplicons with methylated C motifs were cloned by reamplifi.. Read More»
Genet. Mol. Res. 14(4): 2015.November.25.6
DOI: 10.4238/2015.November.25.6
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