L. Zhu
Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU
Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combinat.. Read More»
Genet. Mol. Res. 16(2): gmr16029414
DOI: 10.4238/gmr16029414
Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recently discovered the association of nonalco.. Read More»
Genet. Mol. Res. 12(3): 2013.September.10.2
DOI: 10.4238/2013.September.10.2
Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors
The study aimed to investigate the effect of intrathecal injections of Tanshinone IIA on thermal hyperalgesia in a mouse model of bone cancer-pain. Spinal IL-1β, IL-6, TNF-α expression levels were analyzed. C3H/HeNCrlVr male mice were assigned to groups that either received dose-dependent injections of Tanshinone IIA, or the DMSO + Sham, Tanshinone IIA + Sham, DMSO + Tumor, and Contr.. Read More»
Genet. Mol. Res. 14(1): 2015.March.20.24
DOI: 10.4238/2015.March.20.24
Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population
Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a possible association of MTHFR gene polymor.. Read More»
Genet. Mol. Res. 10(4): 2011.December.14.8
DOI: 10.4238/2011.December.14.8
Relationship between SPOP mutation and breast cancer in Chinese population
SPOP protein has been found to have ubiquitin ligase activity. Mutations in SPOP gene have been recently reported in some cancers such as prostate, gastric, colorectal cancer. We investigated SPOP DNA mutation in tumor tissues collected from 70 Chinese female breast cancer patients in Southwestern China by DNA sequencing. The results did not show mutation in our tis.. Read More»
Genet. Mol. Res. 14(4): 2015.October.16.2
DOI: 10.4238/2015.October.16.2
Effects of cetuximab combined with afatinib on the expression of KDR and AQP1 in lung cancer
In this study, we examined the effect of cetuximab (epidermal growth factor receptor monoclonal antibody) combined with afatinib (epidermal growth factor receptorand human epidermal growth factor receptor 2 tyrosine kinase irreversible inhibitor) on the apoptosis of A549 cells and on kinase domain receptor (KDR) and aquaporin 1 (AQP1) expression in A549 cells. A549 cells were cultured in RPMI-1.. Read More»
Genet. Mol. Res. 14(4): 2015.December.11.12
DOI: 10.4238/2015.December.11.12
Effect of muscle-fiber type on glycogenin-1 gene expression and its relationship with the glycolytic potential and pH of pork
This study analyzed the effect of muscle-fiber type composition on glycogenin-1 (GYG) gene expression and its impact on pH. The longissimus dorsi (LD) muscle contains more type IIB fibers (75.10%) than does the psoas major (PM) muscle (41.58%), while the PM has more type I (3.65 vs 0.94%), type IIA (34.15 vs 10.63%), and type IIX (20.62 vs 13.33%) fibers. Compared with PM, glycolytic potential .. Read More»
Genet. Mol. Res. 12(3): 2013.September.4.4
DOI: 10.4238/2013.September.4.4
Coexpression of interleukin-6 and -2 from giant panda in Escherichia coli and the biological activity of the fusion protein
To construct a fusion cytokine protein with more and stronger bioactivities to enhance the immunity of the cytokine alone, we expressed interleukin (IL)-6/(IL)-2 from giant panda (Ailuropoda melanoleuca) in Escherichia coli as a 59.4-kDa fusion protein. Subsequently, the inclusion bodies were solubilized with 8 M urea and applied onto a Ni-nitrilotriacetic acid column. The final production of I.. Read More»
Genet. Mol. Res. 12(2): 2013.June.14.1
DOI: 10.4238/2013.June.14.1
Metabolic response of LLC xenografted mice to oxythiamine, as measured by [1H] NMR spectroscopy
Oxythiamine (OT) has been proven to be a potential anticancer drug. With the help of NMR-based metabonomics, we studied the metabolic changes within tumor-bearing mice with different levels of OT administration using a C57BL/6 mouse Lewis lung carcinoma tumor transplantation model. We administered different concentrations of OT (75, 150, 300, and 600 mg∙kg-1∙day-1) to the mice orally for 2 .. Read More»
Genet. Mol. Res. 14(3): http://dx.doi.org/2015.September.21.17
DOI: http://dx.doi.org/10.4238/2015.September.21.17
FOXO1 is a tumor suppressor in cervical cancer
Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in cervical cancer than in cervical intraepit.. Read More»
Genet. Mol. Res. 14(2): 2015.June.18.3
DOI: 10.4238/2015.June.18.3
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