H.L. Zhang
Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU
Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combinat.. Read More»
Genet. Mol. Res. 16(2): gmr16029414
DOI: 10.4238/gmr16029414
Comprehensive identification and expression analysis of Hsp90s gene family in Solanum lycopersicum
Heat shock protein 90 (Hsp90) is a protein produced by plants in response to adverse environmental stresses. In this study, we identified and analyzed Hsp90 gene family members using a bioinformatic method based on genomic data from tomato (Solanum lycopersicum L.). The results illustrated that tomato contains at least 7 Hsp90 genes distributed on 6 chromosomes; protein lengths ranged from 267-.. Read More»
Genet. Mol. Res. 14(3): 2015.July.14.7
DOI: 10.4238/2015.July.14.7
Integrated microRNA-mRNA analysis of pancreatic ductal adenocarcinoma
The main aim of this study was to explore the underlying molecular mechanisms and potential target molecules of pancreatic adenocarcinoma. The miRNA (GSE32678) and mRNA (GSE32676) expression profiles of patients with pancreatic ductal adenocarcinoma and healthy controls were downloaded from the Gene Expression Omnibus database. Differentially expressed miRNA and differentially expressed genes w.. Read More»
Genet. Mol. Res. 14(3): http://dx.doi.org/2015.August.28.14
DOI: http://dx.doi.org/10.4238/2015.August.28.14
Stimulation of bacterial biofilms on Th17 immune cells
We investigated the role of bacterial biofilms in stimulating T helper 17 (Th17) cells in infected organisms. The formation of bacterial biofilms isolated from clinical lavage fluid samples was measured. Th17 cells and interleukin 17 (IL-17) levels in the peripheral blood of healthy individuals, people infected by biofilm bacteria, people infected by non-biofilm bacteria, and in the lavage flui.. Read More»
Genet. Mol. Res. 14(3): 2015.July.13.18
DOI: 10.4238/2015.July.13.18
Molecular cloning of the perilipin gene and its association with carcass and fat traits in Chinese ducks
The perilipin (PLIN) gene is a candidate gene of carcass and fat traits in ducks. In order to study the molecular character of the PLIN gene and its function in different breeds of Chinese ducks, samples were obtained from the Chinese Academy of Agricultural Sciences Research Center for Birds, including 95 Peking ducks of the Z2 series, 91 Peking ducks of the Z4 series, 82 hybrid systems (Z2 x .. Read More»
Genet. Mol. Res. 12(2): 2013.May.13.12
DOI: 10.4238/2013.May.13.12
Relationship between serum adiponectin and osteoprotegerin levels and coronary heart disease severity
This study aimed to explore serum adiponectin and osteoprotegerin levels in patients with coronary heart disease (CHD) and their correlation with inflammatory and ischemia factors. From September 2010 to Augest 2010, 347 CHD patients were enrolled for a retrospective analysis. Serum lipoprotein phospholipase A2 (Lp-PLA2), hypersensitive C-reactive protein (hs-CRP), ischemia modified albumin (IM.. Read More»
Genet. Mol. Res. 14(3): http://dx.doi.org/2015.September.21.15
DOI: http://dx.doi.org/10.4238/2015.September.21.15
Investigation of the association of two candidate genes (H-FABP and PSMC1) with growth and carcass traits in Qinchuan beef cattle from China
Growth and carcass traits are economically important quality characteristics of beef cattle and are complex quantitative traits that are controlled by multiple genes. In this study, 2 candidate genes, H-FABP (encoding the heart fatty acid-binding protein) and PSMC1 (encoding the proteasome 26S subunit of ATPase 1) were investigated in Qinchuan beef cattle of China. .. Read More»
Genet. Mol. Res. 13(1): http://dx.doi.org/2014.March.17.15
DOI: http://dx.doi.org/10.4238/2014.March.17.15
Elevated serum homocysteine level in the development of diabetic peripheral neuropathy
The development of diabetic peripheral neuropathy (DPN) is always followed by changes in vascular endothelial cells that are related to the reactivity of the homocysteine (Hcy) sulfhydryl group. In this meta-analysis, we investigated the association of Hcy with the pathogenesis and progression of DPN. We screened the Embase, Ovid, PubMed, Web of Science, Wangfang, a.. Read More»
Genet. Mol. Res. 14(4): 2015.November.30.14
DOI: 10.4238/2015.November.30.14
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