Medical Genetics
Opg/Rankl mRNA dynamic expression in the bone tissue of ovariectomized rats with osteoporosis
Authors: C.W. Li, B. Liang, X.L. Shi and H. Wang
We established animal models of osteoporosis in ovariectomized rats to detect osteoprogerin (Opg)/receptor activator of nuclear factor-κB ligand (Rankl) mRNA expression levels in the tibias and serum estradiol concentrations at different time points. Sixty Sprague-Dawley female rats were randomly selected and divided into an ovariectomized.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.1
- DOI:
- 10.4238/2015.August.10.1
S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation
Authors: Y.J. Sun, X.K. Wang and B.J. Li
We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.4
- DOI:
- 10.4238/2015.August.10.4
Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia
Authors: H.J. Ou, G. Huang, W. Liu, X.L. Ma, Y. Wei, T. Zhou and Z.M. Pan
We determined the alleles of ten single nucleotide polymorphisms (SNPs) in the APOA5/A4/C3/A1 gene cluster and in APOB in Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, and explored the correlation between these SNPs and dyslipidemia through a case-control study design with 250 patients and 250 normal controls. All S.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.8
- DOI:
- 10.4238/2015.August.10.8
Expression profile of tumor suppressor gene RASSF1 in lacrimal gland carcinoma
Authors: C.H. Zeng, B. Guo, J. Chen, W.M. He and Q.L. Luo
We examined the expression pattern of the tumor suppressor gene RAS association domain family gene 1 (RASSF1) in lacrimal gland carcinoma and analyzed its relationship with the oncogenesis and progression of tumors. Sixty-two patients (30 males, 32 females, average age = 47 ± 3.5 years) admitted with lacrimal gland carcinoma to the Department of Op.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.8
- DOI:
- 10.4238/2015.June.26.8
IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis
Authors: Z. Li, Y. Liu, D. Cao, M. Jiang and F. Luo
We conducted a meta-analysis of eligible studies to estimate the association between gastric cancer risk and rs2275913G>A IL-17A and rs763780T>C IL-17F polymorphisms. We searched the relevant studies in both Chinese and English through PubMed, the Web of Science, the Cochrane Library, and EMBASE up to January 1, 2014, including 3939 cases and 5407 c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.10
- DOI:
- 10.4238/2015.June.26.10
Immunomodulatory effect of bone marrow mesenchymal stem cells on T lymphocytes in patients with decompensated liver cirrhosis
Authors: C.H. Guo, L.X. Han, M.R. Wan, G.J. Deng and J.H. Gan
We explored the immunomodulatory effects of bone marrow mesenchymal stem cells (BMSCs) on peripheral blood T lymphocytes in patients with decompensation stage, hepatitis B-associated cirrhosis. MSCs from nine patients were analyzed by flow cytometry. Peripheral blood lymphocytes were isolated for fluorescent staining. Following stimulation by phytohemaggl.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.13
- DOI:
- 10.4238/2015.June.26.13
Expression and clinical significance of PIWIL2 in hilar cholangiocarcinoma tissues and cell lines
Authors: Y.J. Chen, X.F. Xiong, S.Q. Wen, L. Tian, W.L. Cheng and Y.Q. Qi
The objective of this study was to explore the relationship between PIWI-like protein 2 (PIWIL2) and clinicopathological characteristics and prognosis after radical resection. To accomplish this, we analyzed PIWIL2 expression in hilar cholangiocarcinoma tissues and cell lines. PIWIL2 expression was detected by immunohistochemistry in 41 hilar cholangiocar.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.15
- DOI:
- 10.4238/2015.June.26.15
Sublingual vein parameters, AFP, AFP-L3,and GP73 in patients with hepatocellularcarcinoma
Authors: J. Zhao, L.-Y. Guo, J.-M. Yang and J.-W. Jia
This study evaluated the diagnostic value of alphafetoprotein (AFP), AFP heterogeneity 3 (AFP-L3), Golgi protein 73 (GP73), and sublingual vein parameters in hepatocellular carcinoma (HCC). Levels of serum AFP, AFP-L3, GP73, and sublingual vein scores were measured in 34 patients with chronic hepatitis, 65 patients with post-hepatitis B cirrhosis, 71 pati.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.16
- DOI:
- 10.4238/2015.June.26.16
Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk:a meta-analysis
Authors: W.H. Zhai, C.Y. Song, Z.G. Huang and H. Sha
While increasing scientific evidence suggests that the ORMDL3 rs7216389 polymorphism may contribute to a higher susceptibility to asthma, many of the current studies have yielded inconclusive results. This meta-analysis aimed to assess the association between the ORMDL3 rs7216389 polymorphism and the risk of asthma. An extensive literature search for rele.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.3
- DOI:
- 10.4238/2015.June.29.3
The insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease
Authors: S. Simsek, S. Tekes, D. Oral, A. Turkyilmaz, B. Isik, M.R. Isik and H. Akkoc
An insertion/deletion (I/D) polymorphism was identified in intron 16 of the gene encoding the human angiotensin I-converting enzyme (ACE), a candidate gene for chronic obstructive pulmonary disease (COPD). We investigated the relationship between this polymorphism in the ACE gene and the risk of developing COPD. Sixty-six COPD in-patients and 40 non-smoki.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.10
- DOI:
- 10.4238/2013.April.25.10