Medical Genetics
Clinical observational study of conformal radiotherapy combined with topotecan chemotherapy in patients with platinum-resistant recurrent ovarian cancer
Authors: P. Wei,Z.H. Zhang,L. Li,X.L. Du,C.P. Shan and X.G. Sheng
This retrospective study aimed to observe the curative effect and adverse reactions of three-dimensional conformal radiotherapy combined with topotecan chemotherapy in patients with platinum-resistant recurrent epithelial ovarian carcinoma. The chemoradiotherapy group (N = 22) received 15 mv X-rays with 1.8 to 2.0 Gy/f/d radiation, 5 times per week. The t.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.12
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.12
Computational identification and characterization of conserved miRNAs and their target genes in beet (Beta vulgaris)
Authors: J.L. Li, J. Cui and D.Y. Cheng
Highly conserved endogenous non-coding microRNAs (miRNAs) play important roles in plants and animals by silencing genes via destruction or blocking of translation of homologous mRNA. Sugar beet, Beta vulgaris, is one of the most important sugar crops in China, with properties that include wide adaptability and strong tolerance to salinity and impoverished.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.19
- DOI:
- 10.4238/2015.August.7.19
Protective effects of morphine preconditioning in delayed phase on myocardial ischemia-reperfusion injury in rabbits
Authors: X.-H. Lu, K. Ran, Y.-Y. Xiao, D.-L. Yang, Y.-T. Chang, K.-M. Duan and Y.-W. Ou
The aim of this study was to investigate the protective mechanisms of delayed-phase morphine preconditioning on myocardial ischemia-reperfusion injury. Thirty healthy male New Zealand white rabbits were randomly divided into three groups: a sham operation group (C), ischemia-reperfusion group (I/R), and delayed-phase morphine preconditioning group (M) (N .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.3
- DOI:
- 10.4238/2015.August.7.3
Effect of different time phases of radionuclide hepatobiliary scintigraphy on the differential diagnosis of congenital biliary atresia
Authors: Y.X. Guan,Q. Chen,S.H. Wan,J.S. Huang,X.Q. Yang L.J. Pan,Q.I. Zhang,Q. Zhang,Y.J. Ou,X.W. Peng,S.Z. Liu,Q.J. Chen and J. Lou
To investigate the value and essentiality of 6- and 24-h delay hepatobiliary scintigraphy in the differential diagnosis of biliary atresia (BA), we retrospectively analyzed 197 infants (121 boys/76 girls; age range, 3-205 days; average age, 63.9 days) admitted to Jiangxi Children’s Hospital for persistent jaundice (> 2 weeks), hepatosplenomegaly,.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.15
Associations between the SRD5A2 gene V89L and TA repeat polymorphisms and breast cancer risk: a meta-analysis
Authors: D. Zhang, Q. Li, H.-C. Qu, T. Yu and Y.-R. Liu
The 5α-reductase type 2 (SRD5A2) gene plays a significant role in the development of breast cancer. The V89L and TA repeat polymorphisms of the SRD5A2 gene have been considered as risk factors for breast cancer. However, the results have been inconsistent. To resolve this conflict, we performed a meta-analysis of studies with V89L (1144 patients and.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.9
- DOI:
- 10.4238/2015.August.7.9
Association of MyoD1a and MyoD1b gene polymorphisms and meat quality traits in rainbow trout
Authors: W.X. Chen, Y. Ma and K.H. Liu
In this study, we identified myogenic regulatory factors (MRFs) and analyzed the correlation between MRFs and meat quality in rainbow trout. The MyoD1a and MyoD1b genes were cloned from rainbow trout using a homology cloning method. Introns 1 and 2 in the MyoD1a and MyoD1b genes were cloned and submitted to GenBank (accession Nos. FJ623462 and FJ793566). .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.12
- DOI:
- 10.4238/2015.August.7.12
Clinical significance and levels of blood brain natriuretic peptides in patients with persistent atrial fibrillation before and after catheter ablation
Authors: S.Y. Xing, H.L. Wang, P.S. Dong, L.H. Lai, J.H. Zhu, J.F. Zhao and X.Y. Shang
The aim of this study was to observe levels of blood brain natriuretic peptides (BNPs) in patients with persistent atrial fibrillation (AF) before and after catheter ablation. Thirty-six patients with persistent AF (28 successful surgeries and eight recurrent cases) and 36 healthy controls with normal sinus rhythm were recruited for this study. BNP levels.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.3
- DOI:
- 10.4238/2015.June.26.3
Vitamin D receptor gene FokI, TaqI, BsmI, and ApaI polymorphisms and susceptibility to pulmonary tuberculosis: a meta-analysis
Authors: Y.H. Lee and G.G. Song
The aim of this study was to determine whether vitamin D receptor (VDR) genetic polymorphisms are associated with the susceptibility to pulmonary tuberculosis (PTB). MEDLINE and Embase databases and manual literature searches were used. A meta-analysis was conducted on the associations between the VDR FokI, TaqI, BsmI, and ApaI polymorphisms and PTB susce.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.21
- DOI:
- 10.4238/2015.August.7.21
Genome-scale meta-analysis of DNA methylation during progression of lung adenocarcinoma
Authors: Q.H. Zhang, X.H. Dai, Z.M. Dai and Y.N. Cai
Identification of epigenetic alterations in tumors has become a common method for identifying genes critical to cancer development and progression. Thus, we identified DNA methylation alterations on the genome scale during lung adenocarcinoma (LADC) progression to understand the carcinogenic process and identify clinically relevant biomarkers. We found th.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.30
- DOI:
- 10.4238/2015.August.7.30
Opg/Rankl mRNA dynamic expression in the bone tissue of ovariectomized rats with osteoporosis
Authors: C.W. Li, B. Liang, X.L. Shi and H. Wang
We established animal models of osteoporosis in ovariectomized rats to detect osteoprogerin (Opg)/receptor activator of nuclear factor-κB ligand (Rankl) mRNA expression levels in the tibias and serum estradiol concentrations at different time points. Sixty Sprague-Dawley female rats were randomly selected and divided into an ovariectomized.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.1
- DOI:
- 10.4238/2015.August.10.1