Medical Genetics
Multifocal central nervous system hemangioblastoma: a case report and review of the literature
Authors: L.Z. Chu, Z.Z. Guan, J. Liu, H. Yang, X.L. Qi, M.G. Dong, Y.M. Chen, Y.N. Xiang and Y. Li
An effective therapy for multifocal central nervous system hemangioblastoma (CNS HB) is needed. Here, we report a case of multifocal CNS HB. A 43-year-old man was diagnosed with CNS HB by enhanced computed tomography and magnetic resonance imaging. Six solid tumors and one cystic nodule were detected in his cerebellum. The pat.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.3
- DOI:
- 10.4238/2014.September.29.3
Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease
Authors: T.J. Xing, D.F. Jiang, J.X. Huang and Z.L. Xu
MicroRNA molecules have been increasingly regarded as a diagnostic and prognostic marker of certain diseases. The aim of this study was to investigate the expression and clinical significance of miR-122 and miR-29 in liver disease related to hepatitis B virus infection. The serum levels of miR-122 and miR-29 in 20 patients wit.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.4
- DOI:
- 10.4238/2014.September.29.4
Estimation of genetic parameters for growth traits in a breeding program for rainbow trout (Oncorhynchus mykiss) in China
Authors: G. Hu, W. Gu, Q.L. Bai and B.Q. Wang
Genetic parameters and breeding values for growth traits were estimated in the first and, currently, the only family selective breeding program for rainbow trout (Oncorhynchus mykiss) in China. Genetic and phenotypic data were collected for growth traits from 75 full-sibling families with a 2-generation pedigree. Genetic parameters and breeding values for.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.26.7
- DOI:
- 10.4238/2013.April.26.7
Result and pedigree analysis of spontaneously abortion villus chromosome detecting by FISH
Authors: N. An, L.-L. Li, X.-Y. Zhang, W.-T. Sun, M.-H. Liu and R.-Z. Liu
The aim of this study was to evaluate the relationship between fetal karyotype and parental chromosomal abnormalities, and to provide a basis for clinical diagnosis and therapy in Northeast China. A total of 144 spontaneously aborted fetuses were analyzed by FISH to test for chromosome number and to recall couples for peripheral blood karyotype analysis. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.13
- DOI:
- 10.4238/2015.December.11.13
Updated analysis of studies on the cytotoxic T-lymphocyte-associated antigen-4 gene A49G polymorphism and Hashimoto�s thyroiditis risk
Authors: R. Ji, Y. Feng and W.W. Zhan
Published data on the association between the cytotoxic T-lymphocyte-associated antigen-4 gene A49G polymorphism and the risk for Hashimoto’s thyroiditis (HT) are inconclusive. A meta-analysis was performed to derive a more precise estimation. Published case-control studies in English or Chinese were identified. In total, 24 studies with 2295 cases .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.26.4
- DOI:
- 10.4238/2013.April.26.4
Bioequivalence of clopidogrel hydrogen sulfate tablets in healthy Chinese volunteers
Authors: Y.G. Yang, M. Zhang, N. Jiang, L.X. Song, X.T. Xu, X.H. Di, L. Xu, J. Xu and G.T. Zhao
We aimed to evaluate the bioequivalence of clopidogrel in healthy Chinese volunteers after administration of a single oral dose. We administered a single oral dose of 75 mg clopidogrel (test and reference) to 32 healthy Chinese volunteers according to an open, randomized, crossover design. The concentration of clopidogrel acid (carboxylic metabolite of cl.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December14.1
- DOI:
- 10.4238/2015.December14.1
Molecular phylogeny of Lathyrus species: insights from sequence-related amplified polymorphism markers
Authors: S. Marghali, A. Touati, M. Gharbi, D. Sdouga and N. Trifi-Farah
Sequence-related amplified polymorphism (SRAP) markers were used to evaluate the intra- and interspecific variation among 40 Lathyrus genotypes (four species) (Fabaceae). Ten SRAP primer combinations resulted in a total of 94 bands, and they exhibited high interspecific variability. The genetic differentiation among Lathyrus, estimated using AMOVA, was hi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017198
- DOI:
- 10.4238/gmr.15017198
Meta-analysis of the association between the rs7903146 polymorphism at the TCF7L2 locus and type 2 diabetes mellitus susceptibility
Authors: X.H. Liu, C.G. Xie, Y. An, X.X. Zhang and W.B. Wu
Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and environmental factors. T2DM has been associated with specific polymorphisms in the TCF7L2 gene. This study evaluates the relationship between the rs7903146 locus polymorphism of the TCF7L2 gene and T2DM susceptibility through meta-analysis; the overall aim is to provide a basis for.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.12
- DOI:
- 10.4238/2015.December.14.12
Role of ERCC2 and ERCC3 gene polymorphisms in the development of osteosarcoma
Authors: X. Ma, Y. Zhang, T.S. Sun and J.H. Yao
We conducted a case-control study to investigate the role of common SNPs in ERCC2 (rs13181 and rs1799793) and ERCC3 (rs4150441 and rs4150506) in the development of osteosarcoma. A 1:2 matched case-control study was conducted. Between January 2012 and December 2013, 141 patients with pathologically diagnosed osteosarcoma and 282 controls were recruited in .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017302
- DOI:
- 10.4238/gmr.15017302
Co-culture of annulus fibrosus cells and bone marrow mesenchymal stem cells
Authors: Y. Xu,X.J. Zhang,L. Fang and T.B. Zhao
To investigate the effect on cell proliferation and extracellular matrix expression of annulus fibrosus (AF) cells when co-cultured with bone marrow mesenchymal stem cells (BMSCs). Primary isolated rabbit BMSCs and AF cells were cultured and harvested cells were placed into a 15-mL centrifugal tube co-culture system in a ratio of 2:1 (A group), 1:1 (B gro.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.7
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.7