Medical Genetics
High-resolution color doppler ultrasound examination and related risk factor analysis of lower extremity vasculopathy in type 2 diabetes patients
Authors: J. Xu,G. Wang,D. Fu,N. Su,L. Wang,F. Gao and N. Guo
This study aims to investigate the value of high-resolution color Doppler ultrasonography (HR-CDU) in the evaluation of lower-extremity vasculopathy (LEV) and its related risk factors in type 2 diabetes mellitus (T2DM) patients. Two hundred forty T2DM patients were selected, who underwent lower-extremity arterial HR-CDU. The patients were divided into the.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.8
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.8
Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil
Authors: C.R. Hoelzle, K.C.S.F. Magalh�£es, S.S. Carvalho, G.A. Santos, I.M. Maia, M.C.P.S. Sousa, J.S. Andrade-Filho, G.M.G. Cruz and R.T. Sim�µes
We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA e.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017478
- DOI:
- 10.4238/gmr.15017478
Association of the interleukin-10 gene -1082A/G genetic polymorphism with risk of ischemic stroke in a Chinese population
Authors: W.Z. Li, C.Y. Gao, W.L. He and H.M. Zhang
We investigated the possible association between two single nucleotide polymorphisms of IL10 (-1082A/G and -592C/A) and susceptibility to ischemic stroke. In total, 335 patients with proven ischemic stroke and 335 control subjects were recruited from Xinxiang Central Hospital between March 2013 and May 2015. The IL10 -1082A/G and -529C/A polymorphisms wer.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017541
- DOI:
- 10.4238/gmr.15017541
Analysis and clinical significance of microRNA-499 expression levels in serum of patients with acute myocardial infarction
Authors: C.H. Zhao,G.-C. Cheng,R.L. He,Y. Hong,Q.L. Wan,Z.-Z. Wang and Z.-Y. Pan
The aim of this study was to investigate the expression level of microRNA-499 and its clinical significance in serum of patients with acute myocardial infarction (AMI). We recruited 59 patients with AMI and 60 healthy individuals undergoing physical examination in our hospital during the same period as controls. Peripheral blood was drawn in the morning o.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.17
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.17
MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis
Authors: G.L. Shi,L. Yang,Y. Sun,Y.J. Yin and C.X. Song
Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculos.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.18
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.18
R337H mutation of the TP53 gene as a clinical marker in cancer patients: a systematic review of literature
Authors: L.M. Borges and F.M. Ayres
The germline R337H mutation of the TP53 gene has been associated with the development of many tumor types. This systematic review of literature investigated the association between the R337H mutation and the patients’ family history and its predictive and prognostic value in cancer. Data were collected from articles archived in the PubMed, LILACS, M.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.4
- DOI:
- 10.4238/2015.December.16.4
A new repertoire of informations about the quorum sensing system in Salmonella enterica serovar Enteritidis PT4
Authors: M.E.M. Campos-Galv�£o,T.D.S. Leite,A.O.B. Ribon,E.F. Ara�ºjo and M.C.D. Vanetti
Salmonella spp are among the main causative agents of foodborne diseases. Some phenotypes associated with increased drug resistance and virulence are regulated by quorum sensing (QS). In the present study, the autoinducer (AI)-1- and -2-mediated QS mechanisms were characterized in Salmonella enterica serovar Enteritidis PT4 for the first time. Salmonella .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.22
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.22
Major quality trait analysis and QTL detection in hexaploid wheat in humid rain-fed agriculture
Authors: H.M. Li, Z.X. Tang, H.Q. Zhang, B.J. Yan and Z.L. Ren
Humid rain-fed agriculture is a special environment for wheat (Triticum aestivum) culture that tends to negatively affect wheat yield and quality. To identify quality characters of wheat in a humid environment, we conducted quality analysis and quantitative trait loci (QTL) detection in a recombinant inbred line whose parent had a high level of quality fo.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.5
- DOI:
- 10.4238/2013.May.21.5
A novel and efficient strategy for practical identification of tomato (Solanum lycopersicon) varieties using modified RAPD fingerprints
Authors: N.K. Korir, X.Y. Li, X.P. Leng, Z. Wu, C. Wang and J.G. Fang
Tomato breeding and variety development have led to the generation of a large number of varieties in many countries worldwide. This has created a growing and urgent need for an improved strategy for genotyping and identification since the traditional methods based on phenotype are growing unreliable. DNA markers could provide distinct benefits in tomato v.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.11.2
- DOI:
- 10.4238/2013.June.11.2
Telomere-associated factor expression in replicative senescence of human embryonic lung fibroblasts
Authors: H. Du, L. Yang, X.-Y. Xu, L. Hai, Y.-Q. Han and Y.-X. Shi
The objective of this study was to find the key regulatory molecules in the cell senescence process through observing the expression of telomere-associated factor during the normal cell replicative senescence process. Based on the established cell replicative senescence model, reverse transcription-polymerase chain reaction and western blot analyses were .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.7
- DOI:
- 10.4238/2015.August.10.7