Medical Genetics
Correlation between ERCC1 expression and concurrent chemotherapy and radiotherapy in patients with locally advanced nasopharyngeal cancer
Authors: R. Liang, Y. Lin, Z.H. Liu, X.L. Liao, C.L. Yuan, S.N. Liao and Y.Q. Li
In this study, the expression of DNA excision repair cross-complementing gene 1 (ERCC1) in local advanced nasopharyngeal carcinoma has been correlated with the efficacy of concurrent chemoradiotherapy. A total of 76 patients diagnosed with undifferentiated nasopharyngeal carcinoma diagnosed by nasopharyngeal biopsy and undergoing single-agent cisplatin ch.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.12
- DOI:
- 10.4238/2015.May.29.12
Predictive value of CK20 in evaluating the efficacy of treatment and prognosis after surgery for colorectal cancer
Authors: W.X. Li, H.W. Xiao, X.Q. Hong and W.X. Niu
specimens and intraperitoneal drainage fluids, CK20 levels were lower in patients with earlier cancer stages than in those at later stages. During postoperative follow-up, serum negative CK20 patients had significantly higher 3-year survival rates than serum positive CK20 patients. All differences were statistically significant (P < 0.05). CK20 levels .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.14
- DOI:
- 10.4238/2015.May.29.14
Association between single-nucleotide polymorphisms of fatty acid synthase gene and meat quality traits in Datong Yak (Bos grunniens).
Authors: M. Chu, X.Y. Wu, X. Guo, J. Pei, F. Jiao, H.T. Fang,C.N. Liang X.Z. Ding, P.J. Bao and P. Yan
Fatty acid synthase (FASN) is a key enzyme in fatty acid anabolism that plays an important role in the fat deposit of eukaryotic cells. Therefore, in this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) in the FASN gene in 313 adult individuals of Datong yak using polymerase chain reaction-single strand conformation polymorphism and DNA .. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.21
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.21
Cyclin D1 G870A polymorphism is associated with an increased risk of multiple myeloma
Authors: S. Wang, Y. Huang, R. Su, Z. Fang and M. Han
Cyclin D1 is an important cell cycle regulator implicated in the pathogenesis of many cancer types. In particular, translocation and overexpression of cyclin D1 are common events in multiple myeloma (MM), suggesting that it may drive the initiation and progression of this malignancy. However, the association between genetic polymorphisms of cyclin D1 and .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.2
- DOI:
- 10.4238/2015.June.1.2
Development of polymorphic microsatellite loci in Odontobutis obscura using Illumina paired-end sequencing and the test of cross-species amplification
Authors: H.-G. Bae, J. An, J. Jun, S.-M. Kweon, S. Kim, J.-N. Yu, B.-J. Kim, H. Sakai, Y.J. Lee and H.Y. Suk
Odontobutis obscura is a bottom-dwelling freshwater fish native to East Asia. Its range encompasses southwest China, western Japan, and Geoje Island in South Korea. Despite its widespread range in China and Japan, only a small and spatially isolated population is found in South Korea. We developed a total of 23 novel and polym.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038405
- DOI:
- 10.4238/gmr.15038405
Association between TNF-�± rs1800629 polymorphism and the risk of myocardial infarction: A meta-analysis
Authors: X.P. Hua, J. Qian, C.B. Cao, J. Xie, X.T. Zeng and Z.J. Zhang
The tumor necrosis factor-alpha (TNF-α) G-308A polymorphism has been suggested to be a susceptibility factor for myocardial infarction (MI). However, differing results from various studies have led to controversial conclusions. Hence, we performed a meta-analysis to evaluate the association between TNF-α G-308A pol.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037292
- DOI:
- 10.4238/gmr.15037292
Simulating the selfing and migration of Luehea divaricata populations in the Pampa biome to investigate the conservation potential of their genetic resources
Authors: C.M.L. Serrote, L.R.S. Reiniger, V.M. Stefenon, A.R. Curti, L.S. Costa and A.F. Paim
Computer simulations are an important tool for developing conservation strategies for forest species. This study used simulations to investigate the genetic, ecological, and reproductive patterns that contribute to the genetic structure of the tree Lueheadivaricata Mart. & Zucc. in five forest fragments in the Brazilian Pa.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038410
- DOI:
- 10.4238/gmr.15038410
High levels of glucose promote the activation of hepatic stellate cells via the p38-mitogen-activated protein kinase signal pathway
Authors: L.K. Wu, Y.C. Liu, G. Ma, L.L. Shi and X.M. He
The relationship between the p38-mitogen-activated protein kinase (p38-MAPK) signal pathway and high glucose-induced hepatic stellate cell (HSC) activation was investigated in this study. Sixty human HSC samples were randomly selected and used in the control (cultured normally), high-glucose (cultured in the presence of high g.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038419
- DOI:
- 10.4238/gmr.15038419
Kallikrein 12 downregulation reduces AGS gastric cancer cell proliferation and migration
Authors: X.S. Li and X.L. He
Abnormal expression of the kallikrein (KLK) family of serine proteases closely correlates with onset, progression, and prognosis of endocrine gland-related malignant tumors. The aim of this study was to evaluate how downregulation of KLK12 influenced cell cycle and proliferation of the AGS gastric cancer cell line. KLK12 was d.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038452
- DOI:
- 10.4238/gmr.15038452
Population genetic structure and its implication in the conservation of Schizopygopsis pylzovi in Yellow River as inferred from mitochondrial DNA sequence analysis
Authors: 11
To assess the genetic diversity, structure, and population dynamics of Schizopygopsis pylzovi, we examined the changes in mitochondrial DNA sequences (the mtDNA control region and the Cyt b gene; 1835 bp) in 304 individuals from nine populations. The samples were segregated into 112 haplotypes, with high haplotype diversity an.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038480
- DOI:
- 10.4238/gmr.15038480