Medical Genetics
Characterization and evolution of the mitochondrial DNA control region in Ranidae and their phylogenetic relationship
Authors: Z.H. Huang and F.Y. Tu
The control region is considered to be one of the most variable parts of animal mitochondrial DNA (mtDNA). We compared the mtDNA control region from 37 species representing 14 genera and 4 subfamilies of Ranidae, to analyze the evolution of the control region and to determine their phylogenetic relationship. All the Ranidae sp.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038491
- DOI:
- 10.4238/gmr.15038491
Twisting of the spermatic cord: ischemia and reperfusion, toxicogenetic evaluation, and the effects of phosphatidylcholine in pre-clinical trials
Authors: H.R.S. Coelho, C.R. Berno, G.R. Falc�£o, C.R. Hildebrand, R.J. Oliveira and A.C.M.B. Antoniolli-Silva
Phosphatidylcholine is the main phospholipid present in cell membranes and in lipoproteins, and can interfere with various biological processes. This lipid also has antioxidant activity, and protects against damage caused by free radicals under conditions of ischemia/reperfusion. Therefore, the present study was designed toeva.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038529
- DOI:
- 10.4238/gmr.15038529
Immunological function and antibacterial activity of two ferritin proteins from the freshwater pearl mussel Hyriopsis schlegelii
Authors: J.Q. Sheng, Q.C. Shu, J.W. Shi, J.H. Wang, K. Peng, S. Yuan and Y.J. Hong
Ferritin is a conserved iron-binding protein involved in host defense and cellular iron metabolism in most organisms. We investigated the expression profiles of two ferritin genes (designated HsFer-1 and HsFer-2) in the hemocytes, gonad, and hepatopancreas of Hyriopsis schlegelii, when challenged with bacteria and metal ions. .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038533
- DOI:
- 10.4238/gmr.15038533
Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression
Authors: G.-F. Li, T.-L. Qian, G.-S. Li, C.-X. Yang, M. Qin, J. Huang, M. Sun and Y.-Q. Han
Breast cancer is a common cancer in women, with a highly variable course, from inoffensive to lethal. To find a more effective strategy for its treatment, sodium valproate has been tested as an anti-cancer drug; it is the only clinically available histone deacetylase inhibitor. However, data about the effects of sodium valproa.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.13.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.13.1
Prevalence of CYP2C9 and VKORC1 alleles in the Argentine population and implications for prescribing dosages of anticoagulants
Authors: P. Scibona, M.A. Redal, L.G. Garfi, J. Arbelbide, P.F. Argibay and W.H. Belloso
Dicumarinic oral anticoagulants have a narrow therapeutic range and a great individual variability in response, which makes calculation of the correct dose difficult and critical. Genetic factors involved in this variability include polymorphisms of genes that encode the metabolic enzyme CYP2C9 and the target enzyme vitamin K .. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.8
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.8
No evidence for association between DRD3 and COMT with schizophrenia in a Malay population
Authors: S.F. Tee, P.Y. Tang and H.C. Loh
Molecular components of the dopamine D3 receptor (DRD3) may play an important role in the pathophysiology of schizophrenia. Previous studies have demonstrated an association between DRD3 Ser9Gly and cathechol-o-methyltransferase (COMT, SNP = rs165656) polymorphisms and schizophrenia but the results were inconclusive. We invest.. Read More»
- Genet. Mol. Res. 10(3):
Intra- and interspecific variation of cuticular hydrocarbon composition in two Ectatomma species (Hymenoptera: Formicidae) based on Fourier transform infrared photoacoustic spectroscopy
Authors: W.F. Antonialli Junior, Y.R. S�ºarez, T. Izida, L.H.C. Andrade and S.M. Lima
We have been able to discriminate different castes and sexes of ants in the same colony by measuring cuticular hydrocarbon levels with Fourier transform infrared photoacoustic spectroscopy, compared by canonical discriminant function analysis. We have now applied this methodology to various colonies of two species of ants of t.. Read More»
- Genet. Mol. Res. 7(2):
Intrinsically bent DNA in replication origins and gene promoters
Authors: F. Gimenes, K.I. Takeda, A. Fiorini, F.S. Gouveia and M.A. Fernandez
Intrinsically bent DNA is an alternative conformation of the DNA molecule caused by the presence of dA/dT tracts, 2 to 6 bp long, in a helical turn phase DNA or with multiple intervals of 10 to 11 bp. Other than flexibility, intrinsic bending sites induce DNA curvature in particular chromosome regions such as replication origi.. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr461
- DOI:
- 10.4238/vol7-2gmr461
Frequency of the HFE C282Y and H63D polymorphisms in Brazilian malaria patients and blood donors from the Amazon region
Authors: F.R. Torres, W.C. Souza-Neiras, A.A. D�Almeida Couto,V.S.C. D�Almeida Couto, C.E. Cavasini, A.R.B. Rossit, R.L.D. Machado and C.R. Bonini-Domingos
Malaria is an endemic parasitosis and its causitive agent, Plasmodium, has a metabolism linked to iron supply. HFE is a gene with the polymorphisms C282Y and H63D, which are associated with a progressive iron accumulation in the organism leading to a disease called hereditary hemochromatosis. The aim of the present study was to determine the allelic and g.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr408
- DOI:
- 10.4238/vol7-1gmr408
Sperm retrieval from patients with nonmosaic Klinefelter�s syndrome by semen cytologyexamination
Authors: Y.-T. Jiang, Y. Dong, X.-W. Yu, R.-C. Du, L.-L. Li, H.-G. Zhang and R.-Z. Liu
Successful sperm retrieval from ejaculates of nonmosaic Klinefelter’s syndrome (KS) patients by using semen cytology examination was described in this report. The clinical parameters of KS patients with sperm compared to patients without sperm were described. One hundred and fifty-one patients were proven to suffer from .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.12
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.12