Medical Genetics
Effect of flavonoid compounds extracted from Iris species in prevention of carbon tetrachloride-induced liver fibrosis in rats
Authors: Y.L. Wang, H.Y. Lv and Q. Zhang
We investigated the effect of flavonoid compounds extracted from species of genus Iris L. on carbon tetrachloride (CCl4)-induced rat liver fibrosis. Thirty Sprague-Dawley rats were randomly divided into normal control group, liver fibrosis model group, and drug treatment group (N = 10 each). Next, 0.2 mL/100 g CCl4 was subcutaneously injected for 6 weeks .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.9
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.9
Molecular cloning and characterization of the full-length Hsp90 gene from Matricaria recutita
Authors: S.P. Ling, S.S. Su, H.M. Zhang, X.S. Zhang, X.Y. Liu, G.F. Pan and Y. Yuan
Heat shock protein 90 (Hsp90) is one of the most abundant and conserved chaperone proteins and plays important roles in plant growth and responses to environmental stimuli. However, little is known regarding the sequence and function of Hsp90s in Matricaria recutita. In the present study, we cloned the full-length cDNA sequence of the hsp90 gene from this.. Read More»
- Genet. Mol. Res. 13(4):
- 2014
- DOI:
- 10.4238/2014
Association between matrix metalloproteinase-3 polymorphism and anterior cruciate ligament ruptures
Authors: S. Malila, P. Yuktanandana, S. Saowaprut, W. Jiamjarasrangsi and S. Honsawek
Anterior cruciate ligament (ACL) ruptures are considered to be the most severe joint injury in sports. However, the precise etiologies of ACL injuries are not fully understood. Recently, the gene encoding the matrix metalloproteinase-3 (MMP-3, stromelysin-1) was shown to be associated with anterior cruciate ligament ruptures. .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.1
- DOI:
- 10.4238/2011.October.31.1
Effect of age on the immune system and pathology of mice with chronic graft-versus-host disease lupus nephritis
Authors: X.F. Ma, F.L. Xu, L.F. Gao, Y.X. Wang and Z.B. Pan
We investigated the effect of age on the expression of immune molecules [ANA, C4, double stranded DNA (dsDNA), CD16/32, CD19, CD3, and CD64], urine protein, and pathology in mice with chronic graft-versus-host disease (cGVHD) lupus nephritis (LN), and their relationship with reactivity index score. Mouse models of cGVHD LN were established, and mice were .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.12
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.12
Prevalence of vitamin D receptor gene polymorphism in a Uruguayan population and its relation to type 1 diabetes mellitus
Authors: Mimbacas A, Trujillo J, Gascue C, Javiel G and Cardoso H
Vitamin D has important immuno-modulatory properties and it influences insulin secretion. It acts through a vitamin D receptor (VDR), for which several gene polymorphisms have been described. The Uruguayan population presents several epidemiological characteristics that make it different from that of other counties, including .. Read More»
- Genet. Mol. Res. 6(3):
Association between the epithelial cadherin -160C/A gene polymorphism and diffuse gastric cancer risk: a meta-analysis.
Authors: X.W. Chen, J.X. Sun, Z.N. Wang, P. Gao, Y.X. Song, J.F. Cao, B. Liu and H.M. Xu
Several previous studies have investigated whether the -160C/A epithelial cadherin promoter polymorphism confers an increased risk of diffuse gastric cancer (DGC), but conflicting results have been reported. To explore further the association of this polymorphism with DGC susceptibility, we performed an extensive search of rel.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.13.3
- DOI:
- http://dx.doi.org/10.4238/2014.February.13.3
Establishment and characterization of a rat model of hyperphosphatemia
Authors: C. Zhang, Y. Shao, Q.-G. Zhu, Y. Li, C.-L. Jin, H.-P. Wang, L. Zhou, C. Yu, Y.K. Zhao, G.J. Yuan, X.-P. Hu, L. Zhang and H. Wang
We established a rat model of hyperphosphatemia and investigated the systemic effects of high phosphorus (P). Sprague Dawley rats were randomly divided into high (HP), low (LP), and normal (NP) P groups (N = 12 each), which received injections of fructose diphosphate sodium, or were fed self-manufactured low phosphorus or normal diets, respectively. In ea.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.2
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.2
Clonal monosomy of chromosome 21 in a case of myelodysplastic syndrome
Authors: P.C. Freitas, A.B. Carvalho-Salles, C.F. Mendiburu, O. Ricci Jr. and A.C. Fett-Conte
This study reports on a cytogenetic finding in a bone marrow examination of a 47-year-old male patient treated in the Hematology and Blood Transfusion Service of the Hospital de Base in São José do Rio Preto, São Paulo State, Brazil. The only alteration found at diagnosis of myelodysplastic syndrome (MDS) .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.4.5
- DOI:
- 10.4238/2011.November.4.5
FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma
Authors: G.T. Peterle, M. Santos, S.O. Mendes, P.B. Carvalho-Neto, L.L. Maia, E. Stur, L.P. Agostini, C.V.M. Silva, L.O. Trivilin, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A. Silva-Conforti
Currently, the most important prognostic factor in oral squamous cell carcinoma (OSCC) is the presence of regional lymph node metastases, which correlates with a 50% reduction in life expectancy. We have previously observed that expression of hypoxia genes in the tumor inflammatory infiltrate is statistically related to prognosis in OSCC. FAS and FASL exp.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.8
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.8
Lack of an association between -308G>A polymorphism of the TNF-�± gene and liver cirrhosis risk based on a meta-analysis
Authors: D. Chen, J.L. Liu, Y. Liu, J. Zhu and S.W. Wang
TNF-α is a potential proinflammatory cytokine that plays an important role in the pathogenesis of liver cirrhosis. We investigated a possible association between TNF-α -308G>A polymorphism and liver cirrhosis risk by conducting a meta-analysis. Publications addressing the association between TNF-α -308G>.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.8.2
- DOI:
- 10.4238/2011.November.8.2