Medical Genetics
Correlation of EGFR gene amplification with invasion and metastasis of non-small cell lung cancer
Authors: X.F. Jia, J. Li, H.B. Zhao, J. Liu and J.J. Liu
The aim of this study was to explore epidermal growth factor receptor (EGFR) gene amplification and its relationship with cancer invasion and metastasis in non-small cell lung cancer (NSCLC). EGFR amplification in 45 patients with NSCLC and 15 subjects with normal lung tissues was detected by fluorescence in situ hybridization. The relationship between EG.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.13
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.13
Association of interleukin-8 gene polymorphisms in HIV patients with opportunistic infections in Limpopo Province, South Africa
Authors: G.A. Dzhivhuho1, T.C. Nangammbi2 and A. Samie3
Opportunistic infections (OIs) are common among human immunodeficiency virus (HIV) patients; however, genetic susceptibility to these infections has not been studied. Recent studies have shown that interleukin-8 (IL-8) A/T genotype carriers are more susceptible to a variety of diseases. In this study, we showed the effects of IL-8 gene polymorphisms on OI.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017466
- DOI:
- 10.4238/gmr.15017466
Gene and protein expression in the oxaliplatin-resistant HT29/L-OHP human colon cancer cell line
Authors: Z. Xiang, Q.J. Kang and X. Xiang
Oxaliplatin (L-OHP) is one of the most commonly used anticancer drugs in adjuvant treatment of colon cancer after complete resection of the primary tumor and treatment of metastatic colorectal cancer. Cancer cells eventually become resistant to L-OHP, which diminishes its curative effect. However, the mechanism of action of L-OHP remains unknown. In this .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.14
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.14
Chemical synthesis and improved expression of recombinant human granulocyte colony-stimulating factor cDNA
Authors: S. Alrokayan
Recently, granulocyte colony-stimulating factor (G-CSF) has been recognized as a useful molecule for the treatment of a wide range of complex ailments, such as cancer, AIDS, H1N1 influenza, cardiac and neurological diseases. The vast therapeutic potential of G-CSF has induced scientists to develop biotechnological approaches f.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.18
- DOI:
- 10.4238/2011.October.31.18
Efficacy of combined hepatitis B immunoglobulin and hepatitis B vaccine in blocking father-infant transmission of hepatitis B viral infection
Authors: L.-H. Cao, Z.-M. Liu, P.-L. Zhao, S.-C. Sun, D.-B. Xu, M.-H. Shao and J.-D. Zhang
The aim of this study was to examine the efficacy of combined immunization of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine (HBVac) in blocking father-infant transmission of hepatitis B virus (HBV). Newborns positive at birth for blood HBV surface antigen (HBsAg) and/or HBV DNA were selected and immunized with HBIG combination HBVac. At 7 mont.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.24
- DOI:
- 10.4238/2015.May.4.24
Metabolic response of LLC xenografted mice to oxythiamine, as measured by [1H] NMR spectroscopy
Authors: H. Lu, W.X. Lan, L. Bo, C. Niu, J.J. Zhou and H.L. Zhu
Oxythiamine (OT) has been proven to be a potential anticancer drug. With the help of NMR-based metabonomics, we studied the metabolic changes within tumor-bearing mice with different levels of OT administration using a C57BL/6 mouse Lewis lung carcinoma tumor transplantation model. We administered different concentrations of OT (75, 150, 300, and 600 mgâ.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.17
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.17
Association of MEF2A gene 3'UTR mutations with coronary artery disease
Authors: X.C. Huang and W. Wang
Association of variants in the myocyte enhancer factor 2A (MEF2A) gene and the risk of coronary artery disease (CAD) has drawn much attention but remains controversial. We hypothesized that the 3'-untranslated region (3'-UTR) of this gene could harbor functionally relevant nucleotide changes. Here, we assessed the association between single nucleotide pol.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.20
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.20
Values for serum procalcitonin, C-reactive protein, and soluble triggering receptor expressed on myeloid cells-1 in predicting survival of patients with early-onset stroke-associated pneumonia
Authors: J. Xie, X.H. Zhang and W.Y. Zhu
We examined the value of serum procalcitonin (PCT), C-reactive protein (CRP), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for predicting the survival of patients with early-onset stroke associated pneumonia (EOP). A total of 207 stroke patients were enrolled, and 91 developed EOP. Upon admission, serum PCT, CRP, sTREM-1 levels, clin.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.4
- DOI:
- 10.4238/2015.May.11.4
Effect of single nucleotide polymorphisms in the ATP-binding cassette B1 gene on the clinical outcome of traumatic brain injury
Authors: Z.L. Wang, D.S. Xu, Y.X. Wang, H. Qin and D. Geng
The critical role of ATP-binding cassette B1 (ABCB1) in the function of the blood-brain barrier led us to conducted this prospective study in order to investigate the clinical outcome of patients suffering from severe traumatic brain injury. A total of 182 patients with traumatic brain injury were included in our study. Genotyping of ABCB1 C3435T and G267.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.6
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.6
Effect of flavonoid compounds extracted from Iris species in prevention of carbon tetrachloride-induced liver fibrosis in rats
Authors: Y.L. Wang, H.Y. Lv and Q. Zhang
We investigated the effect of flavonoid compounds extracted from species of genus Iris L. on carbon tetrachloride (CCl4)-induced rat liver fibrosis. Thirty Sprague-Dawley rats were randomly divided into normal control group, liver fibrosis model group, and drug treatment group (N = 10 each). Next, 0.2 mL/100 g CCl4 was subcutaneously injected for 6 weeks .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.9
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.9