Medical Genetics
Application of MUTIC to the exploration of gene expression data in prostate cancer
Authors: Goertzel B, Pennachin C, Coelho LS and Mudado MA
We show here an example of the application of a novel method, MUTIC (model utilization-based clustering), used for identifying complex interactions between genes or gene categories based on gene expression data. The method deals with binary categorical data which consist of a set of gene expression profiles divided into two bi.. Read More»
- Genet. Mol. Res. 6(4):
Infection of Plasmodiophora brassicae in Chinese cabbage
Authors: R. Ji*, L. Zhao*, M. Xing, X. Shen, Q. Bi, S. Peng and H. Feng
Brassica crops infected by Plasmodiophora brassicae can produce root galls (clubroots) and be prevented from growing normally. To understand the series of changes that occur in the host root during root gall production, the resistance character of 21 Chinese cabbage lines were identified and then resistant and susceptible lines were used for infection obs.. Read More»
- Genet. Mol. Res. 13(4):
- 2014
- DOI:
- 10.4238/2014
association between a new 3q;5q chromosomal translocation and dystrophy of human retinal pigment epithelium
Authors: Pereira SRF, Silva AS, Bormann EP and Kuppinger O
Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal degeneration. This group of disorders essentially leads to blindness due to mutations in different genes. The genetic basis affected by sporadic and inherited autosomal dominant, autosomal recessive or X-linked mutations is complex. In humans, RP is in mos.. Read More»
- Genet. Mol. Res. 6(4):
Association of peroxisome proliferator-activated receptor-delta polymorphisms with sugar metabolism indices and tumor necrosis factor alpha level
Authors: X.J. Yu, B.L. Su, X.M. Wang, H.J. Feng and C.J. Jin
This study aims to investigate the association of peroxisome proliferator-activated receptor (PPAR) delta -87T/C polymorphism with several sugar metabolism indices and tumor necrosis factor α (TNF α) level. The body mass index (BMI), waist size, and levels of fasting plasma glucose, serum lipid, fasting insulin, TN.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.1
- DOI:
- 10.4238/2014.July.7.1
Identification of a Panax ginseng fruit fingerprint by HPLC-ESI-MS
Authors: H.F. Zhao1, F.F. Xu2, Y.T. Guo1 and H. Mi1
Over many years, parts of Panax ginseng (root and rhizome) have been identified and applied for medical purposes as traditional Chinese herbal medicine. Recently, research has indicated that ginseng fruit also contains similar compounds and is as rich as the other parts of the ginseng. This discovery may dramatically improve the efficient of outputs deriv.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017235
- DOI:
- 10.4238/gmr.15017235
Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model
Authors: Chaves GM, Bates S, MacCallum DM and Odds FC
Resistance of Candida albicans to reactive oxygen species is thought to enhance its virulence in mammalian hosts. Genes such as SOD1, which encodes the anti-oxidant, superoxide dismutase, are known virulence factors. We disrupted the gene GRX2, which encodes a putative glutathione reductase (glutaredoxin) in C. albicans, and w.. Read More»
- Genet. Mol. Res. 6(4):
Effects of VEGF suppression by small hairpin RNA interference combined with radiotherapy on the growth of cervical cancer
Authors: L. Qi, L.N. Xing, X. Wei and S.G. Song
This study aimed to investigate the inhibition of vascular endothelial growth factor (VEGF) by small hairpin RNA (shRNA) interference combined with radiotherapy on the growth of cervical cancer SiHa cell xenografts in nude mice. The effective pVEGF-shRNA plasmid was screened by reverse transcription-polymerase chain reaction (.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.2
- DOI:
- 10.4238/2014.July.7.2
Clinical effects and safety review of self-expanding stent surgery for extracranial carotid artery stenosis treatment
Authors: Q.F. Zhu, S.Z. Fang, G.F. Wang, Z.Z. Zhou, S.C. Bian, S.D. Cui, S.B. Yu, F.W. Wang, L.B. Shan and J. Kang
This study aimed to investigate the clinical effects and safety review of self-expanding stent surgery in the treatment of extracranial carotid artery stenosis. Seventy-eight patients with carotid artery stenosis were applied with the self-expanding stent for endovascular interventional therapy. Eighty-one stents were implante.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.5
- DOI:
- 10.4238/2014.July.7.5
Serum levels of high-sensitivity troponin T: a novel marker for left ventricular remodeling and performance in hypertensive subjects
Authors: D.M. Miao, L.P. Zhang*, H.P. Yu*, J.Y. Zhang, W.K. Xiao and P. Ye
It has been well established that high-sensitivity cardiac troponin T (hs-TnT) is a specific and highly sensitive marker in acute coronary syndromes. On the other hand, studies on serum concentrations of hs-TnT in patients with hypertension in the absence of significant coronary stenosis are limited. Therefore, we hypothesized.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.7
- DOI:
- 10.4238/2014.July.7.7
Reevaluation of RAPD markers involved in a case of stingray misidentification (Dasyatidae: Dasyatis)
Authors: V.V. Faria L.S. Rolim L.A.L. Vaz M.A.A. Furtado-Neto
We investigated a reported case of stingray Dasyatis americana misidentification not detected in a published study using the random amplified polymorphic DNA (RAPD) technique. If the referred specimen (landed by fisheries in Ceará, northeastern Brazil) was misidentified (as Dasyatis centroura) in the field, why did its RAPD data fail to clarify the.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.25.2
- DOI:
- 10.4238/2012.October.25.2