Medical Genetics
Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma
Authors: H.B. Liu, Y. Zhu, Q.C. Yang, Y. Shen, X.J. Zhang and H. Chen
We examined disintegrin and metalloproteinase 17 (ADAM17) protein expression in esophageal squamous cell carcinoma and its clinical and pathological correlated factors. Western blotting and immunohistochemistry were used to detect ADAM17 protein expression in esophageal squamous cell carcinoma and the corresponding normal esophageal mucosa in 50 cases. AD.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.April.30.12
- DOI:
- 10.4238/2015.April.30.12
Genetic affinities of central China populations.
Authors: H.Y. Zhou, H.W. Wang, S.N. Tan, Y. Chen, W.L. Wang, H.X. Tao, Z.C. Yin, Y.H. Zou, S.M. Ouyang and B. Ni
Hunan locates in the south-central part of China, to the south of the middle reaches of the Yangtze River and south of Lake Dongting. According to the historical records, the peopling of Hunan by modern human ancestors can ascend to 40 thousand years ago. Thus, to trace the ancient maternal components can offer further insight.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.28.7
- DOI:
- http://dx.doi.org/10.4238/2014.January.28.7
TGF-�²1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients
Authors: J. Ma, Y.C. Liu, Y. Fang, Y. Cao and Z.L. Liu
Transforming growth factor-beta 1 (TGF-β1), a member of the transforming growth factor beta family, functions as a multi-functional cytokine and plays a key role in cellular growth, proliferation, and differentiation. The 509 C/T polymorphism in the TGF-β1 gene has been implicated in the outcome of hepatitis C virus (HCV) infection; however, lit.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.3
- DOI:
- 10.4238/2015.May.4.3
A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese
Authors: L.Q. Shen, Y.Z. Xie, X.F. Qian, Z.X. Zhuang, Y. Jiao and X.F. Qi
Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let- 7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes i.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.8
- DOI:
- 10.4238/2015.May.4.8
Expression of high-mobility group box protein 1 in diabetic foot atherogenesis
Authors: C.F. Tsao, W.T. Huang, T.T. Liu, P.W. Wang, C.W. Liou, T.K. Lin,C.J. Hsieh and S.W. Weng
The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabe.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.10
- DOI:
- 10.4238/2015.May.4.10
Novel bioinformatic identification of differentially expressed tissue-specific and cancer-related proteins from the Human Protein Atlas for biomarker discovery
Authors: X.-X. Liu and F.-J. Liu
Identification of cancer-associated and tissue-specific proteins is important for research on carcinogenesis mechanisms and biomarker discovery. Here we performed a new strategy to identify candidate cancer proteins by mining immunohistochemistry protein profiles. Proteins with quantitative values from 14 normal tissues and their corresponding cancer tiss.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.14
- DOI:
- 10.4238/2015.May.4.14
Association between the rs189037 single nucleotide polymorphism in the ATM gene promoter and cognitive impairment
Authors: X. Ding, J.R. Yue, M. Yang, Q.K. Hao, H.Y. Xiao, T. Chen, L.Y. Gao and B.R. Dong
The aim of this study was to explore the existence of a relationship between the rs189037 single nucleotide polymorphism (SNP) of the ataxia telangiectasia mutated (ATM) gene and cognitive impairment in the elderly (aged 60 years and above). In a cohort, 505 residents of Suinung City were consecutively recruited and their cognitive function was measured u.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.17
- DOI:
- 10.4238/2015.May.4.17
Prediction and biochemical characterization of intrinsic disorder in the structure of proteolysis-inducing factor/dermcidin
Authors: Majczak G, Lilla S, Garay-Malpartida M, Markovic J, Medrano FJ, de Nucci G and Belizario JE
Proteolysis-inducing factor/dermcidin (PIF/DCD) is a novel human gene, located on chromosome 12, locus 12q13.1, that encodes a secreted 110-amino acid protein. Two transcripts for the protein have been identified in normal skin, breast, placenta and brain, and in various primary and metastatic tumor cells. The putative native-.. Read More»
- Genet. Mol. Res. 6(4):
Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer
Authors: L. Zhang, R.-X. Xi and X.-Z. Zhang
We conducted a case-control study to investigate the role of matrix metalloproteinase (MMP) 2, MMP3, and MMP9 single nucleotide polymorphisms on susceptibility to esophageal squamous cell carcinoma (ESCC) in a Chinese population, and their association with environmental factors. A total of 226 patients with ESCC, and 226 age- and gender-matched healthy co.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.20
- DOI:
- 10.4238/2015.May.4.20
Cloning and characterization of a SnRK2 gene from Jatropha curcas L
Authors: J. Chun, F.-S. Li, Y. Ma, S.-H. Wang and F. Chen
Although the SnRK2 class of Ser/Thr protein kinases is critical for signal transduction and abiotic stress resistance in plants, there have been no studies to examine SnRK2 in Jatropha curcas L. In the present study, JcSnRK2 was cloned from J. curcas using the rapid amplification of cDNA end technique and characterized. The JcSnRK2 genomic sequence is 257.. Read More»
- Genet. Mol. Res. 13(4):
- 2014
- DOI:
- 10.4238/2014