Medical Genetics
Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway
Authors: C. Wang, X. You, C. Jiang, C. Jin, X. Meng and D. Ding
Hepatocyte growth factor (HGF) is a protective factor in myocardial injury, but its mechanisms of action have not yet been fully elucidated. Nexilin, which locates specifically to the Z-disc, is a novel Z-disc protein that enables the Z-discs to persistently withstand the extreme mechanical forces generated during muscle contraction. Therefore, we investi.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.12
- DOI:
- 10.4238/2014.July.4.12
Distribution of HLA-B27 and CYP2D6*4 mutations in the middle Black Sea area (Tokat) of Turkey
Authors: S. Sahin, L. Aydogan, I. Benli and H. Ozyurt
We analyzed distribution of HLA-B27 and CYP2D6*4 mutations in 249 patients from Tokat province in Turkey with symptoms of arthritis, sacroiliac, joint and back pain, using a LightCycler 480 II Real-Time PCR thermal cycler. The Genes-4U was applied for studying HLA-B27 mutation, and the Tib-Molbiol commercial kit was used to ex.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.2.3
- DOI:
- 10.4238/2011.December.2.3
Association between miR-137 polymorphism and risk of schizophrenia: a meta-analysis
Authors: M.L. Ou, G. Liu, D. Xiao, B.H. Zhang, C.C. Guo, X.G. Ye, Y. Liu, N. Zhang, M. Wang, Y.J. Han, X.H. Ye, C.X. Jing and G. Yang
miR-137, a brain-enriched microRNA, is involved in the control of neuronal proliferation, differentiation, and dendritic arborization, all of which are important for proper neurogenesis and relevant to schizophrenia. miR-137 is also known to regulate many genes implicated in schizophrenia risk. Although reports have associated the miR-137 polymorphism rs1.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038703
- DOI:
- 10.4238/gmr.15038703
An improved DNA marker technique for genetic characterization using RAMP-PCR with high-GC primers
Authors: C.L. Wei, J.L. Cheng, M.A. Khan, L.Q. Yang, S. Imani, H.C. Chen and J.J. Fu
Random amplified polymorphic DNA (RAPD) is a widely used molecular marker technique. As traditional RAPD has poor reproducibility and productivity, we previously developed an improved RAPD method (termed RAMP-PCR), which increased the reproducibility, number of bands, and efficiency of studies on polymorphism. To further develop the efficiency of this met.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038721
- DOI:
- 10.4238/gmr.15038721
Novel mutations in the FUCA1 gene that cause fucosidosis
Authors: W. Panmontha1, P. Amarinthnukrowh, P. Damrongphol, T. Desudchit, K. Suphapeetiporn and V. Shotelersuk
Fucosidosis is a rare lysosomal storage disorder inherited in an autosomal recessive manner. Its estimated frequency is below 1 in 200,000 live births. Its clinical phenotypes include progressive neurological and mental deterioration, coarse facial features, growth retardation, visceromegaly, angiokeratomas, and seizures. The disease is caused by mutation.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038733
- DOI:
- 10.4238/gmr.15038733
Pleural resection and pleural infusion chemotherapy for therapy of malignant pleural mesothelioma
Authors: J. Zhang, Q. Zhang, W. Zhao, J. Duan and T. Huang
The aim of this study was to evaluate effective treatment methods of malignant pleural mesothelioma (MPM). Twenty-three patients with MPM were cured by pleural infusion chemotherapy after surgery. Median survival time and the 1-, 2-, and 3-year survival rates were analyzed on the basis of follow-up. Median survival time of all.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.17
- DOI:
- 10.4238/2014.January.21.17
Association of a CYP4A11 polymorphism and hypertension in the Mongolian and Han populations of China
Authors: J.Q. Liang, M.R. Yan, L. Yang, Q. Suyila, H.W. Cui and X.L. Su
Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE). We therefore investigated the association between a CYP4A11 polymorphism (rs9333025) with hypertension in the Mongolian and Han ethnic groups. We studi.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.20
- DOI:
- 10.4238/2014.January.21.20
Study on serum proteomic features in patients with and without recurrence or metastasis after surgical resection of esophageal carcinoma
Authors: G.B. Zheng, C.F. Gao, X.L. Wang, G. Zhao and D.H. Li
The purpose of this study was to identify specific biomarkers for recurrence or metastasis of esophageal carcinoma in serum of patients subjected to esophagectomy. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) combined with IMAC-Cu2+ ProteinChip array were performed for the serum .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.23
- DOI:
- 10.4238/2014.January.21.23
Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer
Authors: X.P. Huang, W.H. Zhou and Y.F. Zhang
Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual’s susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise e.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.24.17
- DOI:
- 10.4238/2014.January.24.17
A novel technique for analyzing the similarity and dissimilarity of DNA sequences
Authors: Y.W. Liu and Y. Peng
li,j denotes the distance between the point (xi, yi) and the point (xj, yi) in graphical representation. By classifying li,j, i, j = 1, 2,…, N according to the number of points between (xi, yi) and (xj, yi), N - 1 types are obtained. The average and variance of every type are assembled by the novel invariant v = (a1, d1, a2, d2,…, aN, dN). C.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.2
- DOI:
- 10.4238/2014.January.28.2