Medical Genetics
Aspergillus nidulans as a biological system to detect the genotoxic effects of mercury fumes on eukaryotes
Authors: G.D. Sousa, T.D. Zucchi, F.D. Zucchi, R.G. Miller1, R.M.A. Anjos,P. Poli and T.M.A.D. Zucchi
Mercury (Hg) pollution is one of the most serious environmental problems. Due to public concern prompted by the symptoms displayed by people who consumed contaminated fish in Minamata, Japan in 1956, Hg pollution has since been kept under constant surveillance. However, despite considerable accumulation of knowledge on the nox.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr587
- DOI:
- 10.4238/vol8-2gmr587
Efficient identification of ornamental peach cultivars using RAPD markers with a manual cultivar identification diagram strategy
Authors: J. Han, W.Y. Wang, X.P. Leng, L. Guo, M.L. Yu, W.B. Jiang and R.J. Ma
One of the most important uses of DNA markers is cultivar identification. However, no DNA fingerprint analysis strategy is available for making DNA markers helpful in practical plant cultivar identification, especially for the identification of a large number of cultivars. We developed a manual cultivar identification diagram .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.2
- DOI:
- 10.4238/2014.January.8.2
New loci of Lychnophora ericoides and transferability to Lychnophora pinaster, endangered medicinal species from Brazil
Authors: M.A.R. Vieira, M.O.M. Marques, L.L. Haber, B.B.Z. Vigna, M.M. Bajay, J.B. Pinheiro, A.P. Souza, J. Semir and M.I. Zucch
Lychnophora ericoides and Lychnophora pinaster are species used in popular medicine as analgesic or anti-inflammatory 21 simple sequence repeat loci of L. ericoides were developed and transferred to L. pinaster. Three populations of L. ericoides and 2 populations of L. pinaster were evaluated; they were collected in the State of Minas Gerais. Population p.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.19.8
- DOI:
- 10.4238/2014.December.19.8
Association of XRCC5 polymorphisms with COPD and COPD-related phenotypes in the Han Chinese population: a case-control cohort study
Authors: B. Wang, J. Yang, J. Xiao, B. Liang, H.X. Zhou, Z. Su, S. Xu, H. Chen, C. Ma, J. Deng, D. Li, H. Zhou, X. Ou and Y. Feng
Genome-wide association studies (GWAS) and integrative genomic approaches have demonstrated significant associations between chronic obstructive pulmonary disease (COPD) and polymorphisms of the X-ray repair cross-complementing protein 5 gene (XRCC5) in non-Asian populations. We investigated whether XRCC5 polymorphisms might b.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.January.24.11
- DOI:
- 10.4238/2014.January.24.11
Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma
Authors: H.F. Zhang, J.P. Yan, Y.S. Zhuang and G.Q. Han
The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C a.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.14
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.14
Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-�±
Authors: T. Yu, Q. Lu, X.L. Ou, D.Z. Cao and Q. Yu
TNF 308 gene polymorphism and IL-10 polymorphism provided evidence in diagnosing some types of cancer. We aimed to explore the relation of gene polymorphism with gastric cancer. A total of 360 cases of gastric cancer patients were included in the study. The genotypes GG, GA, and AA of the interleukin-10-1082 gene (IL-10-1082) and the tumor necrosis factor.. Read More»
- Genet. Mol. Res. 13(4):
- http://dx.doi.org/2014.December.19.12
- DOI:
- http://dx.doi.org/10.4238/2014.December.19.12
Comprehensive analysis of patched domain-containing genes reveals a unique evolutionary pattern
Authors: Y. Zhong, L.J. Gu*, X.G. Sun, S.H. Yang and X.H. Zhang
Patched domain-containing genes are members of a small family originally identified in Drosophila. A common feature of transmembrane patched domain-containing proteins is their function in the transport of sterols, sterol-modified proteins, and lipids. Recently, an expansion phenomenon of patched domain-containing gen.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.13.11
- DOI:
- 10.4238/2014.February.13.11
Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis
Authors: L.L. Zhang, J. Gong and C.T. Liu
Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We se.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.13.10
- DOI:
- 10.4238/2014.February.13.10
Association between p53 codon 72 polymorphisms and clinical outcome of nasopharyngeal carcinoma
Authors: M.L. Li, Y. Dong, Y.Z. Hao, N. Xu, F.L. Ning, S.S. Chen and J.M. Yu
We conducted a cohort study to investigate whether polymorphisms in p53 at codon 72 are associated with tumor response and survival time of advanced nasopharyngeal carcinoma (NPC) patients treated with radiotherapy. The study population included 127 subjects with NPC who were enrolled at Binzhou Medical University between September 2008 and December 2009... Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.19.9
- DOI:
- 10.4238/2014.December.19.9
A mixed colony of Scaptotrigona depilis and Nannotrigona testaceicornis (Hymenoptera, Apidae, Meliponina)
Authors: C. Menezes, M. Hrncir and W.E. Kerr
We describe a case of a spontaneously established mixed colony of two species of stingless bees. The host colony of Scaptotrigona depilis, an aggressive bee that forms large colonies, was invaded by workers of Nannotrigona testaceicornis, a smaller bee that forms small colonies. The host colony and the invading species colony .. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2keer002
- DOI:
- 10.4238/vol8-2keer002