Medical Genetics
-174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race
Authors: S. Mandal, F. Abebe and J. Chaudhary
Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation cou.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.5
- DOI:
- 10.4238/2014.January.10.5
Association of plasma B-type natriuretic peptide concentration with myocardial infarct size in patients with acute myocardial infarction
Authors: J.M. Niu, Z.L. Ma, C. Xie and Z.Q. Zhang
B-type natriuretic peptide (BNP) is widely used in the treatment of early-stage heart failure and coronary heart disease. In this study, the association of plasma BNP concentration with myocardial infarct (MI) size in patients with acute myocardial infarction (AMI) was investigated. Eighty patients with AMI were enrolled in th.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.21.6
- DOI:
- 10.4238/2014.February.21.6
Biochip analysis of prostate cancer
Authors: M.Q. Fan, P.X. Wang, J.Y. Feng, Y. Xiao and C.B. Huang
Microarray expression analysis was used to forecast the roles of differentially co-expressed genes (DCG) and DCG and links in the pathogenesis of prostate cancer. In addition, we demonstrate that the relationship between transcriptional factors (TFs) and their targets can be considered a key factor in determining the differenc.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.6
- DOI:
- 10.4238/2014.January.10.6
Construction of a lentiviral vector encoding heme oxygenase 1 and its introduction into mouse adipose tissue-derived stem cells
Authors: C.H. Zhu, W. Lei and Z.R. Chen
Many studies exist concerning the use of stem cells as delivery vehicles in gene therapy, expressing genes such as vascular endothelial growth factor 165 and hepatocyte growth factor. However, few reports regarding adipose tissue-derived stem cells (ADSCs) and the heme oxygenase 1 (HO-1) gene have been published. Therefore, we established a lentiviral vec.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.10
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.10
Screening of differentially expressed genes in pathological scar tissues using expression microarray
Authors: L.P. Huang, Z. Mao, L. Zhang, X.X. Liu, C. Huang and Z.S. Jia
Pathological scar tissues and normal skin tissues were differentiated by screening for differentially expressed genes in pathologic scar tissues via gene expression microarray. The differentially expressed gene data was analyzed by gene ontology and pathway analyses. There were 5001 up- or down-regulated genes in 2-fold differentially expressed genes, 956.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.13
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.13
Expression of c-myc and mutation of the KRAS gene in patients with ovarian mucinous tumors
Authors: X.S. Li, J. Sun and X.L. He
We examined the expression of c-myc and mutations in the KRAS gene in ovarian mucinous tumors to explore the pathogenesis of these tumors and the feasibility of targeted gene therapy. Expression of c-myc protein and mutations in the KRAS gene in 24 cases of ovarian mucinous cystadenoma, 46 cases of ovarian borderline mucinous cystadenoma, and 46 cases of .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.14
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.14
Application of genomics and proteomics in drug target discovery
Authors: H.M. Zhang, Z.R. Nan, G.Q. Hui, X.H. Liu and Y. Sun
Gene medicine is making breakthroughs in health questions that have baffled humanity for centuries. To understand and utilize gene medicine, it is necessary to realize its action against targets at the molecular level. Currently, many methods can be used to discover drug targets; among these, genomic and proteomic methods are .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.11
- DOI:
- 10.4238/2014.January.10.11
Molecular identification and first report of mitochondrial COI gene haplotypes in the hawksbill turtle Eretmochelys imbricata (Testudines: Cheloniidae) in the Colombian Caribbean nesting colonies
Authors: L. Daza-Criado and J. Hern�¡ndez-Fern�¡ndez
Hawksbill sea turtles Eretmochelys imbricata are found extensively around the world, including the Atlantic, Pacific, and Indian Oceans; the Persian Gulf, and the Red and Mediterranean Seas. Populations of this species are affected by international trafficking of their shields, meat, and eggs, making it a critically e.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.21.14
- DOI:
- 10.4238/2014.February.21.14
Sperm chromatin dispersion by formaldehyde in Wistar rats
Authors: N.D. Betancourt-MartÃ?Ânez, J. JimÃ?©nez-Villarreal, P. Carranza-Rosales, N.E. GuzmÃ?¡n-Delgado, C. Leyva Orasma, E. Viveros Valdez and J. MorÃ?¡n-MartÃ?Ânez
Formaldehyde (FA) is an environmental xenobiotic, which is genotoxic and carcinogenic to humans and animals; it induces DNA damage, mutations, and clastogenicity during critical cytogenetic events. FA-mediated oxidative stress is an important mechanism that has been associated with the induction of cytotoxic and genotoxic damage. Therefore, the objective .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.20
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.20
RNA-seq reveals the downregulated proteins related to photosynthesis in growth-inhibited rice seedlings induced by low-energy N+ beam implantation
Authors: Q.F. Chen, H.Y. Ya, W.D. Wang and Z. Jiao
Transcriptomic research based on RNA sequencing (RNA-seq) technology is innovative and will provide new opportunities and biological perspectives for the use of ion-beam implantation in plants. Using RNA-seq, transcriptomes of whole rice seedlings generated from seeds implanted with a low-energy N+ beam were analyzed 96 h afte.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.26.9
- DOI:
- 10.4238/2014.March.26.9