Medical Genetics
Toll-like receptor 3 polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in the Chinese
Authors: Y. Cheng, M.W. Li, H.P. Li, W.T. Zeng, P. Zhou, L.Z. Huang, X.X. Li and Y.Y. Sun
Toll-like receptor 3 (TLR3) variants in mainland northern Chinese patients with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) were investigated. The complete genes of TLR3, including all exons and the promoter region, were assessed using direct sequencing technology of 284 unre.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.17.15
- DOI:
- 10.4238/2014.January.17.15
Proteomic analysis of non-tumoral breast tissue
Authors: G.G. Costa, R. Kaviski, L.E.R. Souza, C.A. Urban, R.S. Lima, I.J. Cavalli and E.M.S.F. Ribeiro
Breast cancer is a complex and heterogeneous disease. In spite of the advances made in recent decades, a better understanding of the intrinsic mechanisms of this disease is crucial. The development of new biomarkers is absolutely necessary to improve diagnosis and prognosis. Research using the proteomic approach has generated .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.3.3
- DOI:
- 10.4238/2011.October.3.3
Prospective analysis of KRAS wild-type patients with metastatic colorectal cancer using cetuximab plus FOLFIRI or FOLFOX4 treatment regimens
Authors: M.Y. Huang, M.J. Chen, H.L. Tsai, C.H. Kuo, C.J. Ma, M.F. Hou, S.C. Chuang, S.R. Lin and J.Y. Wang
Cetuximab, a monoclonal antibody targeting epidermal growth factor receptor, has proven to be efficient in the treatment of metastatic colorectal cancer. We made a prospective study of the efficacy and toxicities of cetuximab-combination first-line (FOLFOX4) versus second/third-line (FOLFIRI) chemotherapy in 98 KRAS wildtype p.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.3.4
- DOI:
- 10.4238/2011.October.3.4
Prevalence of �²-lactamase classes A, C, and D among clinical isolates of Pseudomonas aeruginosa from a tertiary-level hospital in Bangkok, Thailand
Authors: C. Katvoravutthichai, K. Boonbumrung and R. Tiyawisutsri
Pseudomonas aeruginosa is one of the most important causes of nosocomial infection and it has increasing resistance to many antimicrobial agents. β-lactamase production is the most frequent mechanism for β-lactam resistance in P. aeruginosa. We evaluated the prevalence of β-lactamase genes in P. aeruginosa for classes A, C, and D by polymer.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038706
- DOI:
- 10.4238/gmr.15038706
Direct sequencing of mutations in the copper-transporting P-type adenosine triphosphate (ATP7B) gene for diagnosis and pathogenesis of Wilson�s disease
Authors: D.F. Zhang and J.F. Teng
Copper-transporting P-type adenosine triphosphatase (ATP7B) has been identified as the pathogenic gene in hepatolenticular degeneration, or Wilson’s disease (WD). The aim of this study was to explore the correlation between genetic mutations and the clinical profile of WD, and to discuss the value of mutation examination in its diagnosis for providi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038746
- DOI:
- 10.4238/gmr.15038746
Prominent contribution of Th1, Th17, and Tregs to the host response during M. neoaurum infection
Authors: C.F. Wang, W.T. Yang, L.M. Yue, J.Y. Qiu, L.J. Zhang, C. Wang, X.Y. Jiang and A.D. Qian
Nontuberculous mycobacteria are ubiquitous in outside environment and animals. As for nontuberculous mycobacteria infection, there is only limited information in humans regarding infection and the subsequent immune response, especially for Mycobacterium neoaurum. Here, haematoxylin-eosin and Ziehl-Neelsen staining were used to observe pathological changes.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038989
- DOI:
- 10.4238/gmr.15038989
Role of inflammatory parameters in the susceptibility of cerebral thrombosis
Authors: X.F. Qi, T.J. Feng, P. Yang, H.Y. Feng, P. Zhang, L.Y. Kong, D.L. Liang, P.F. Li, W. Na, Y.W. Li and Y. Wang
We aimed to investigate the association of inflammation-related genes such as IL-10, IL-6 and IL-1B with risk of ischemic stroke. We included 426 cases with ischemic stroke and 426 health controls from Xinxiang, China. Genomic DNA was extracted from the buffy coat layer of collected blood with the TIANamp blood DNA kit. Diabet.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.16.1
- DOI:
- 10.4238/2014.April.16.1
Synthesis and structure-activity relationship of oleanolic mono- or di-glycosides against Magnaporthe oryzae
Authors: G. Huo, C. Liu, Y. Hui, X. Chen and D. Xiao
Saponins are naturally-occurring units with broad diversity and are usually recognized as phytoanticipins. In order to develop new saponin chemical entities with high activity against Magnaporthe oryzae, we selected oleanolic acid (OA), which has wide natural distribution and rich content in plants. We used the ability of OA to act as an aglycone for glyc.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038998
- DOI:
- 10.4238/gmr.15038998
Effects of different doses of Savda Munziq on myocardial ischemia-reperfusion injury in rats with abnormal Savda syndrome
Authors: A. Maimaitiaili, A. Shabiti, M. Abudureheman, Z. Musha, Q. Jun, G. Maimaitiaili, A. Aibibula and H. Upur
To investigate the effects of different doses of abnormal Savda Munziq on myocardial ischemia-reperfusion injury (MI/RI) in rats with the abnormal Savda syndrome, 50 abnormal Savda animal models were randomly divided into a control group, a model group, a high-dose group, a middle-dose group, and a low-dose group, with each gr.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.2.2
- DOI:
- 10.4238/2014.July.2.2
Prevalence of cystathionine beta synthase gene mutation 852Ins68 as a possible risk for neural tube defects in eastern India
Authors: A.K. Saxena, J. Gupta, S. Pandey, A.N. Gangopadhaya and L.K. Pandey
Cystathionine beta synthase gene (CβS) catalyzes the condensation of homocysteine with serine, forming cystathionine by the transsulfuration pathway. Disruption of CβS enzyme activity due to defective folic acid metabolism increases the risk factor for neural tube defects. We evaluated the CβS gene mutation in 2.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.7.4
- DOI:
- 10.4238/2011.October.7.4