Human Genetics
rs3918242 MMP9 gene polymorphism is associated with myocardial infarction in Mexican patients
Authors: J.M. RodrÃ?Âguez-PÃ?©rez1*, G. Vargas-AlarcÃ?³n1*, R. Posadas-SÃ?¡nchez2,T.X. Zagal-JimÃ?©nez1, R. OrtÃ?Âz-AlarcÃ?³n1, B. Valente-Acosta1, C. Tovilla-ZÃ?¡rate3, C. Nostroza-HernÃ?¡ndez1, O. PÃ?©rez-MÃ?©ndez1 and N. PÃ?©rez-HernÃ?¡ndez1,4
Several studies have demonstrated that matrix metalloproteinases (MMPs) play a major role in atherosclerotic plaque disruption and lead to myocardial infarction (MI). We investigated the association between the MMP1 -1607 1G/2G (rs1799750), MMP3 -1612 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms and the risk of developing MI in a Mexica.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017776
- DOI:
- 10.4238/gmr.15017776
Assessment of the mutagenic, genotoxic and cytotoxic potential of the waters of the Preto River in the area influenced by S�£o Jos�© do Rio Preto, SP
Authors: L.R. Maschio
-.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3ta020
- DOI:
- 10.4238/vol8-3ta020
Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis
Authors: Y.H. Lee S.-C. Bae G.G. Song
We investigated whether Toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis and whether they influence clinical characteristics of rheumatoid arthritis. Studies were considered relevant for our meta-analysis if at least two comparisons of an issue were available. Eleven studies with 2078 patients with rheumatoid arthritis .. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.7.2
- DOI:
- 10.4238/2013.February.7.2
Effects of probucol on cultured human umbilical vein endothelial cells injured by hypoxia/reoxygenation
Authors: Y.L. Chai, J.Z. Xu, Y.L. Zhang and G.T. Sheng
There is increasing evidence suggesting that endoplasmic reticulum stress (ERS) plays an important role in the initiation and development of atherosclerosis. This study was designed to examine the effect of probucol on cultured human umbilical vein endothelial cells (HUVECs) injured by hypoxia/reoxygenation (H/R) and the potential mechanisms involving ERS.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016752
- DOI:
- 10.4238/gmr.15016752
The role of smoking status and collagen IX polymorphisms in the susceptibility to cervical spondylotic myelopathy
Authors: Z.C. Wang, J.G. Shi, X.S. Chen, G.H. Xu, L.J. Li and L.S. Jia
We investigated a possible association of collagen IX tryptophan (Trp) alleles (Trp2 and Trp3) and smoking with cervical spondylotic myelopathy (CSM) in 172 Chinese patients and 176 age- and gender-matched controls. The smoking status was evaluated by smoking index (SI). The CSM cases had a significantly higher prevalence of T.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.9.2
- DOI:
- 10.4238/2012.May.9.2
Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors
Authors: Z.H. Chen, J.F. Xian and L.P. Luo
Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals’ susceptibility to cancers. We aimed to investigate the asso.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018877
- DOI:
- 10.4238/gmr16018877
Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells
Authors: Y. Deng, J. Sun and L.D. Zhang
The purpose of this study was to investigate the effect of ST2825, an inhibitor of myeloid differentiation factor 88 (MyD88), on the proliferation and apoptosis of human hepatocellular carcinoma (HCC) cells as well as the potential mechanism and clinical significance of ST2825 in the treatment of HCC. Immunohistochemical staining with an MyD88 antibody wa.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016826
- DOI:
- 10.4238/gmr.15016826
Comparative study of 13 candidate genes applying multi-reference normalization to detect the expression of different fineness in skin tissues of wool sheep
Authors: Y.Z. Tian, T. Usman, K.C. Tian, J. Di, X.X. Huang, X.M. Xu, H. Tulafu, W.W. Wu, X.F. Fu, Y. Bai, M. Tuerxun and A. Maimaiti
Fiber diameter is a useful indicator of wool traits and it is the main determinant of wool quality and value. A comparative study was conducted to analyze the abundance and expression of 13 candidate genes using expression profile microarray analysis and to identify novel molecular markers associated with wool traits to provid.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018905
- DOI:
- 10.4238/gmr16018905
Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population
Authors: J.D. Sun, H. Yuan, H.Q. Hu and H.M. Yu
We investigated the possible correlations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of coronary heart disease (CHD). CHD patients (113) and healthy controls (118) were enrolled from the First People’s Hospital of Yuhang between January 2013 and June 2014. The patients were divided into mild CHD (N = 72) and severe CHD (N =.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016954
- DOI:
- 10.4238/gmr.15016954
Frequency of alterations in the MEFV gene and clinical signs in familial Mediterranean fever in Central Anatolia, Turkey
Authors: G.G. Ceylan, C. Ceylan and E. Ozturk
Familial Mediterranean fever is a recessive autoinflammatory disease that is frequent in Armenians, Jews, Arabs, and Turks. The MEFV gene is responsible for this disease. We looked for MEFV gene variations (polymorphism and mutations) in a population that resides in Central Anatolia, Turkey. DNA was extracted from peripheral b.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.7.4
- DOI:
- 10.4238/2012.May.7.4