Human Genetics
Differential expression of hENT1 and hENT2 in colon cancer cell lines
Authors: Y. Liu, T. Zuo, X. Zhu, N. Ahuja and T. Fu
Human equilibrative nucleoside transporters (hENT) 1 and 2, encoded by SLC29A1 and SLC29A2, permit the bidirectional passage of nucleoside analogues into cells and may correlate with clinical responses to chemotherapy in patients with colorectal cancer (CRC). The purpose of this study was to evaluate the expression profiles of.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019549
- DOI:
- 10.4238/gmr16019549
Dysregulation of gene expression in a patient with depressive disorder after transient ischemic attack confirmed by a neurophysiological neuromarker
Authors: M. Trystu��a, M. �»ychowska, M. Wilk-Fra��czuk, J.D. Kropotov and M. P��chalska
The aim of this study was to evaluate dysregulation of gene expression associated with the cellular stress response in a patient with a post-“warning stroke” depressive disorder confirmed by the presence of a neurophysiological neuromarker through the use of quantitative EEG and event-related potentials. The patien.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019532
- DOI:
- 10.4238/gmr16019532
Effects and mechanism of lipoic acid on beta-amyloid-intoxicated C6 glioma cells
Authors: Z.G. Xing, G.D. Yu, L. Qin, F. Jiang and W.H. Zhao
β-amyloid peptides (Aβs) can exert neurotoxic effects through induction of oxidative damage, whereas lipoic acid (LA), a powerful antioxidant, can alleviate oxidative damage. In this study, we explored the effect and mechanism of action of LA on beta-amyloid-intoxicated C6 glioma cells. Cells were randomly divided into three groups: control (veh.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.8
- DOI:
- 10.4238/2015.October.29.8
Lack of association of the G22A polymorphism of the ADA gene in patients with ankylosing spondylitis
Authors: U. Camargo, R.A. Toledo, J.R. Cintra, D.P.T. Nunes, R. Acayaba de Toledo, C.C. Brand�£o de Mattos and L.C. Mattos
Genes located outside the HLA region (6p21) have been considered as candidates for susceptibility to ankylosing spondylitis. We tested the hypothesis that the G22A polymorphism of the adenosine deaminase gene (ADA; 20q13.11) is associated with ankylosing spondylitis in 166 Brazilian subjects genotyped for the HLA*27 gene (47 p.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.7.3
- DOI:
- 10.4238/2012.May.7.3
5-Fluorouracil induces apoptosis of colorectal cancer cells
Authors: J.T. Zhang1, W.L. Zhou2, C. He3, T. Liu1, C.Y. Li1 and L. Wang1
5-Fluorouracil (5-FU) is widely used in chemotherapy for treatment of colorectal cancer. Leucine-rich repeat-containing G protein-coupled receptor (LGR) is known to participate in the occurrence and development of breast cancer by regulating the rebirth of tumor vessels. This study aimed to explore the proliferation and apoptosis of HCT116 colorectal canc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017326
- DOI:
- 10.4238/gmr.15017326
Vasculogenic mimicry and hypoxia-inducible factor-1�± expression in cervical squamous cell carcinoma
Authors: T.J. Zhou1, X.H. Huang1, L. Gong1 and L. Xiang2
In this study, the existence of vasculogenic mimicry (VM) in cervical squamous cell carcinoma was investigated. To this end, the relationship between hypoxia-inducible factor 1α (HIF-1α) and the development, infiltration, and metastasis of cervical squamous cell carcinoma was studied. Between January 2010 and December 2010, 67 human cervical s.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017396
- DOI:
- 10.4238/gmr.15017396
CsSAD: a fatty acid desaturase gene involved in abiotic resistance in Camellia sinensis (L.)
Authors: Z.T. Ding1,2*, J.Z. Shen1,2*, L.L. Pan1,2, Y.U. Wang1,2, Y.S. Li3, Y. Wang4 andH.W. Sun5
Tea (Camellia sinensis L.) is a thermophilic evergreen woody plant that has poor cold tolerance. The SAD gene plays a key role in regulating fatty acid synthesis and membrane lipid fluidity in response to temperature change. In this study, full-length SAD cDNA was cloned from tea leaves using rapid amplification of cDNA ends and polymerase chain reaction .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017512
- DOI:
- 10.4238/gmr.15017512
Inhibition of mitochondrial calcium uptake 1 in Drosophila neurons
Authors: P.G. M�Angale and B.E. Staveley
The mitochondrial calcium uptake 1 (MICU1) is a regulatory subunit of the mitochondrial calcium uniporter that plays an important role in calcium sensing. It contains two EF-hand domains that are well conserved across diverse species from protozoa to plants and metazoans. The loss of MICU1 function in mammals is attributed to .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019436
- DOI:
- 10.4238/gmr16019436
Migration and invasion enhancer 1 (MIEN1) is overexpressed in breast cancer and is a potential new therapeutic molecular target
Authors: H.-B. Zhao, X.-F. Zhang, H.-B. Wang and M.-Z. Zhang
Migration and invasion enhancer 1 (MIEN1) is a membrane-anchored protein that is highly expressed in various types of cancer, and is correlated with the PI3K/AKT pathway. The aim of this study was to investigate the expression of MIEN1 and its clinical pathological significance in breast cancer. We used immunohistochemical sta.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019380
- DOI:
- 10.4238/gmr16019380
Common genetic risk factors of venous thromboembolism in Western and Asian populations
Authors: S.S. Huang1*, Y. Liu2*, Z.C. Jing3, X.J. Wang3 and Y.M. Mao1
Venous thromboembolism (VTE) is a multifactorial disorder involving both acquired and genetic risk factors. The common genetic factors in Western populations have been studied and reported for several decades, while studies on Asian populations are relatively scarce. Evidence suggests that the prevalence and genetic risk factors of VTE vary significantly .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017644
- DOI:
- 10.4238/gmr.15017644