Human Genetics
Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas
Authors: P.K. Mishra, S.K. Jatawa, G.V. Raghuram, N. Pathak, A. Jain,A. Tiwari, S. Varshney and K.K. Maudar
Gallbladder carcinoma is an uncommon, but highly malignant tumor, with poor prognostic, and diagnostic manifestations in early stages. The Indian Council of Medical Research reported increased incidence of gallbladder carcinoma in the surviving population of the Bhopal gas tragedy that involved exposure of more than 500,000 pe.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr653
- DOI:
- 10.4238/vol8-4gmr653
Effects of grafting on key photosynthetic enzymes and gene expression in the citrus cultivar Huangguogan
Authors: L. Liao1, S.Y. Cao1, Y. Rong1 and Z.H. Wang1,2
Grafting influences scion photosynthetic capacity and fruit quality. Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), which strongly affects photosynthetic rate, and Rubisco activase (RCA), which regulates Rubisco activity, are two key photosynthetic enzymes. However, little information is available regarding the effect of grafting on the concen.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017690
- DOI:
- 10.4238/gmr.15017690
Effect of GJB2 235delC and 30-35delG genetic polymorphisms on risk of congenital deafness in a Chinese population
Authors: Y. Xiong, M. Zhong, J. Chen, Y.L. Yan, X.F. Lin and X. Li
Congenital deafness is a serious and irreversible condition in humans. The GJB2 gene is implicated in the pathogenesis of autosomal recessive nonsyndromic hearing loss. Its 235delC and 30-35delG polymorphisms are reported to be associated with risk of hereditary deafness. However, the effect of the interaction between GJB2 235.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019165
- DOI:
- 10.4238/gmr16019165
Expression of microRNA-210 in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion
Authors: T.Y. Liu1, H. Zhang2, S.M. Du3, J. Li1 and X.H. Wen1
This study investigated the expression of microRNA-210 (miR-210) in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion. Thirty-two renal carcinoma patients in our hospital were selected as the study group and 32 people receiving a physical examination were selected as the control grou.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017746
- DOI:
- 10.4238/gmr.15017746
First cytogenetic study of Cavernicola pilosa Barber, 1937 (Hemiptera, Triatominae)
Authors: E.S. Souza, K.C.C. Alevi, A.R. Ribeiro, M.B. Furtado, N.C.B.V. Atzingen, M.T.V. Azeredo-Oliveira and J.A. Rosa
Cavernicola pilosa is a triatomine species that lives in caves and feeds on bat blood. This vector has a wide geographical distribution, and is found in Brazil, Colombia, Panama, Peru, and Venezuela. Little is known about the reproductive biology of this species, because most previous studies have only characterized its morphology, morphometry, ecology, a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.9
- DOI:
- 10.4238/2015.October.29.9
Molecular identification of Echinococcus granulosus on the Tibetan Plateau using mitochondrial DNA markers
Authors: D. Hu, X. Song, N. Wang, X. Zhong, J. Wang, T. Liu, Z. Jiang, T. Dawa, X. Gu, X. Peng and G. Yang
Cystic echinococcosis (CE) is an important worldwide zoonotic disease that causes large economic losses and human suffering. Echinococcus granulosus, the causative agent of CE, exhibits different genotypes in different locations. In order to identify its genotypes and analyze its genetic structure on the Tibetan Plateau, we collected 72 hydatid cysts from.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.12
- DOI:
- 10.4238/2015.October.29.12
Nested polymerase chain reaction technique for the detection of Gpc3 and Afp mRNA in liver cancer micrometastases
Authors: J. Luo, K. Yang and Y.G. Wen
The incidence of liver cancer has gradually risen to a high level in China, and tumor metastasis occurs via multiple pathways. Alpha fetal protein (AFP) is the main biomarker of liver cancer micrometastases. A recent study showed that glypican-3 (GPC3), which is abundant in hepatoma cells, has promising specificity and could b.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018947
- DOI:
- 10.4238/gmr16018947
ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk
Authors: N. Jiang, G. Yang and C.L. Peng
The aim of this meta-analysis was to evaluate the correlations between the estrogen receptor 1 (ESR1) gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) and the risk of cardiovascular disease (CVD). Case-control studies were screened and selected from a larger group of studies that were retrieved through a comprehensive search of scient.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.14
- DOI:
- 10.4238/2015.October.29.14
Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway
Authors: Z.G. Peng1, D.C. Liu2, Y.B. Yao1, X.L. Feng3, X. Huang1, Y.L. Tang1, J. Yang1 and X.X. Wang1
Paclitaxel (PTX) is a mitotic inhibitor widely used in chemotherapy for many types of cancers, including solid tumors and hematological malignancies. However, the molecular basis of the anti-proliferation activity of PTX is not fully understood. In this paper, we focused on the role of c-Jun N-terminal kinase (JNK) pathways in PTX-induced apoptosis and pr.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15013904
- DOI:
- 10.4238/gmr.15013904
Lack of association of C282Y and H63D mutations in the hemochromatosis (HFE) gene with diabetes mellitus type 2 in a case-control study of women in Brazil
Authors: K.B. Gomes, M.G. Carvalho, F.F. Coelho, I.F. Rodrigues, A.L. Soares, D.A. Guimar�£es and A.P. Fernandes
Hereditary hemochromatosis is one of the most common autosomal recessive diseases; it is characterized by excess absorption of iron. Clinically, the major challenge is to diagnose increased iron deposition before irreversible tissue damage has occurred. C282Y and H63D are the main mutations related to hereditary hemochromatosi.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr663
- DOI:
- 10.4238/vol8-4gmr663