Human Genetics
Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1
Authors: Y. Wu, Y.-N. Wei, W.-Y. Yue, W.-F. Chen and S. Fu
We investigated the effects of gossypol acetic acid (GAA) on the proliferation, apoptosis, and expression of DNA methyltransferase 1 (DNMT1) mRNA in human adenoid cystic carcinoma (ACC-M) cells in vitro. The proliferation and apoptosis of ACC-M cells after treatment with different concentrations of GAA were detected using Cell Counting Kit-8 and flow cyto.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.6
- DOI:
- 10.4238/2015.October.28.6
Identification of molecular markers related to human alveolar bone cells and pathway analysis in diabetic patients
Authors: X. Sun, Q.H. Ren, L. Bai and Q. Feng
Alveolar bone osteoblasts are widely used in dental and related research. They are easily affected by systemic diseases such as diabetes. However, the mechanism of diabetes-induced alveolar bone absorption remains unclear. This study systematically explored the changes in human alveolar bone cell-related gene expression and biological pathways, which may .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.8
- DOI:
- 10.4238/2015.October.28.8
GSTM1 polymorphism in patients with primary open-angle glaucoma
Authors: A.M. Barbosa A.B. Frare N.B. Costa R.E. Silva K.K.V.O. Moura
Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally blind. .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.12.8
- DOI:
- 10.4238/2012.September.12.8
Blockade of S100A3 activity inhibits murine hair growth
Authors: W. Guan, Q. Deng, X.L. Yu, Y.S. Yuan, J. Gao, J.J. Li, L. Zhou, P. Xia, G.Y.Q. Han, W. Han and Y. Yu
Using mouse gene expression microarray analysis, we obtained dynamic expression profiles of the whole genome in a depilation-induced hair growth mouse model. S100A3 expression increased during the anagen phase and returned to normal during the telogen phase. The effects of S100A3 blockade on the hair growth cycle were examined in mice after subcutaneous i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.14
- DOI:
- 10.4238/2015.October.28.14
Dithranol downregulates expression of Id1 mRNA in human keratinocytes in vitro
Authors: C. Ronpirin T. Tencomnao
The precise causes of psoriasis, a chronic skin disorder characterized by hyperproliferation of keratinocytes and incomplete keratinization, are unclear. It is known that expression of helix-loop-helix transcription factor Id1, which functions as an inhibitor of differentiation, is upregulated in psoriatic skin. We investigated the effect of the antipsori.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.12.12
- DOI:
- 10.4238/2012.September.12.12
Occurrence of mutations in loci linked to Y chromosome in the offspring born to individuals exposed to ionizing radiation
Authors: J.T. Arruda
In September 1987, in Goiânia, GO, Brazil, one of the most serious radiological accidents occurred at a radiotherapy unit involving a source of cesium-137. An area of 2000 m2 was contaminated and 249 people were exposed, both externally and internally, to substantial doses of ionizing radiation, resulting in four fatalities due to acute radiation sy.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3ta021
- DOI:
- 10.4238/vol8-3ta021
Role of MTHFR C677T polymorphism in systemic carcinogenesis, besides its role in the pathogenesis of colo-rectal carcinomas
Authors: S. Kapoor
--.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.24.2
- DOI:
- 10.4238/2012.September.24.2
Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk
Authors: Y.M. Zhang X.C. Zhou Z. Xu C.J. Tang
In order to make a comprehensive assessment of the potential association between two genetic variants in the IL-10 gene promoter, -1082 A>G (rs1800896) and -592 C>A (rs1800872), and colorectal cancer (CRC) risk, we conduced a meta-analysis of seven epidemiological studies, which included 1469 colorectal cancer cases and 2566 controls. Neither of the.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.25.7
- DOI:
- 10.4238/2012.September.25.7
Proteomics-based approach for identification and purification of human phosphate binding apolipoprotein from amniotic fluid
Authors: M. Alam1, M. Mahajan1, M. Raziuddin2, T.P. Singh1 and S. Yadav1
Human amniotic fluid is of both maternal and fetal origin; it protects the fetus and provides the environment for growth and development of the fetus. We used a proteomics-based approach for targeting and purifying human phosphate binding protein, a member of the DING family of proteins from amniotic fluid, using Blue Sepharose CL-6B, DEAE-Sephacel and ge.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr620
- DOI:
- 10.4238/vol8-3gmr620
Effectiveness of muscle basal lamina carrying neural stem cells and olfactory ensheathing cells in spinal cord repair
Authors: X.W. Kang, J.L. Hu, S.K. Wang and J. Wang
We examined the effect of muscle basal lamina (MBL) with neural stem cells (NSCs) and olfactory ensheathing cells (OECs) on spinal cord injury repair. Seventy-two Sprague-Dawley rats were subjected to spinal cord hemisection and divided into 6 groups. In blank control group (group A), the ends of the spinal cord hemisection model were flushed with physiol.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.5
- DOI:
- 10.4238/2015.October.28.5