Human Genetics
Full-sib reciprocal recurrent selection in the maize populations Cimmyt and Piran�£o
Authors: K.S. da Cunha M.G. Pereira L.S.A. Gon�§alves A.P.C.G. Berilli E.C. de Oliveira H.C.C. Ramos A.T. do Amaral J�ºnior
We estimated the genetic gains of the 12th cycle of reciprocal recurrent selection for maize traits of agronomic interest. We used 23 ISSR molecular markers in an attempt to maximize genetic variability among and within populations based on selection of S1 progenies. To this end, 138 full-sib families were evaluated in a randomized block design in two enviro.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.25.8
- DOI:
- 10.4238/2012.September.25.8
Prevalence of Plasmodium falciparum and P. vivax in an area of transmission located in Par�¡ State, Brazil, determined by amplification of mtDNA using a real-time PCR assay
Authors: C.R.T. Souza T.A.A. Carvalho R.C.G. Amaral L.S. Cunha M.G. Cunha J.F. Guerreiro
The need for a more sensitive and time-efficient assay for malaria has led to the development of molecular assays involving real-time PCR (qPCR), a procedure that has the potential to detect low levels of parasitemia, identify mixed infections, and allow for precise differentiation of species via melting curve analysis or TaqMan fluorescence-labeled probe.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.25.9
- DOI:
- 10.4238/2012.September.25.9
Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population
Authors: M.Y. Zhao Y. Xue Z.Q. Zhao F.J. Li D.P. Fan L.L. Wei X.J. Sun X. Zhang X.C. Wang Y.X. Zhang J.C. Li
Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear. We examined whether single nucleotide polymorphisms at positions -1145 and -159 in the promoter region of the CD14 gene are associate.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.25.11
- DOI:
- 10.4238/2012.September.25.11
Case-control investigations of a DRD2 missense variant in Asian populations: more noise, less signal
Authors: P.G. Sand
--.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.25.14
- DOI:
- 10.4238/2012.September.25.14
Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk
Authors: D.Y. Zhong H.Y. Chu M.L. Wang L. Ma D.N. Shi Z.D. Zhang
The functional polymorphism Ser326Cys (rs1052133) in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in bladder cancer risk. However, reports of this association between the Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to help clarify this relationship, we made a meta-analysis of seven case-control studi.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.26.4
- DOI:
- 10.4238/2012.September.26.4
Bioinformatics analysis with graph-based clustering to detect gastric cancer-related pathways
Authors: P. Liu X. Wang C.H. Hu T.H. Hu
Despite a dramatic reduction in incidence and mortality rates, gastric cancer still remains one of the most common malignant tumors worldwide, especially in China. We sought to identify a set of discriminating genes that could be used for characterization and prediction of response to gastric cancer. Using bioinformatics analysis, two gastric cancer datas.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.26.5
- DOI:
- 10.4238/2012.September.26.5
Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis
Authors: F. Zhang Y. Yang D. Hu H. Lei Y. Wang
Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.26.7
- DOI:
- 10.4238/2012.September.26.7
Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility
Authors: A.C.F. Finotti1,2, R.C.P. Costa e Silva1,2, B.M. Bordin1,2, C.T.X. Silva2 and K.K.V.O. Moura1,2
Male infertility is a heterogeneous disorder, with various genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxifying enzymes of phase II drug metabolism can modify their expression or functi.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr642
- DOI:
- 10.4238/vol8-3gmr642
New insights into telomeric DNA sequence (TTAGGG)n location in bat chromosomes
Authors: K.C. Faria1, S.R.C. Marchesin3, P.R.L. Moreira2, M.R. Beguelini2and E. Morielle-Versute3
Molossidae species, Cynomops abrasus (2n = 34, fundamental number, FN = 64), Eumops auripendulus (2n = 42, FN = 62), Molossus rufus (2n = 48, FN = 64), Molossops temminckii (2n = 48, FN = 64), and Nyctinomops laticaudatus (2n = 48, FN = 64), and Phyllostomidae species, Phyllostomus discolor (2n = 32, FN = 60), have karyotypes with different chro.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr637
- DOI:
- 10.4238/vol8-3gmr637
Analysis of vaccine potential of live recombinant and inactivated wild strains of Corynebacterium pseudotuberculosis
Authors: F.A. Dorella
Caseous lymphadenitis (CLA) is a worldwide chronic disease that affects sheep and goats, whose etiological agent is Corynebacterium pseudotuberculosis. Despite all the economic losses caused by CLA, there is not much information about molecular mechanisms in the pathogenesis of this bacterium, and immune prophylaxis against the infection is not able to re.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3ta022
- DOI:
- 10.4238/vol8-3ta022