Human Genetics
Dynamic relationship between SIPA1 gene and protein expression and the development of gastric cancer
Authors: J.Y. Li, J.B. Wang, C.B. Liu, D.L. Ma, J.H. Ma
Association of signal-induced proliferation-associated 1 (SIPA) gene and protein expression with gastric cancer development was examined. SIPA1 mRNA and protein levels were determined by real-time quantitative polymerase chain reaction and western blot, respectively, in 40 gastric tumor and tumor-adjacent normal tissues. SIPA1.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019271
- DOI:
- 10.4238/gmr16019271
Paracrine effect of bone marrow mesenchymal stem cells on proliferation, apoptosis, and alpha-actin-2 expression in hepatic stellate cells
Authors: H.-J. Cao, M.-D. Wang, S.-G. Li, L. Zhu, J.-H. Zheng
We investigated the paracrine effects of bone marrow mesenchymal stem cells (BMSCs) on the proliferation, apoptosis, and alpha-actin-2 (ACTA2) expression of hepatic stellate cells (HSCs), and explored the possible mechanisms of hepatocyte growth factor (HGF). We established a co-culture system by culturing BMSCs on the upper layer and HSCs on the lower la.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019201
- DOI:
- 10.4238/gmr16019201
Expression profiling based on coexpressed modules in obese prepubertal children
Authors: J.F. Zhang G.Y. Yao Y.H. Wu
The aim of this study was to identify related genes and the underlying molecular mechanisms in obese patients who show a series of clinical and metabolic abnormalities known as metabolic syndrome. We identified expression profiles through a coexpression network. In addition, a similarity matrix and expression modules were constructed based on domain and p.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.5
- DOI:
- 10.4238/2012.August.31.5
Co-inheritance of variants/mutations in Malaysian patients with Crohn�s disease
Authors: K.H. Chua C.C. Ng I. Hilmi K.L. Goh
Crohn’s disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deeper layers of the digestive wall. Two Crohn’s disease patients who carried the JW1 variant and two patients who carried the SNP5 variant were investigated for other co-inherited polymorphisms that could influence Crohn’s disease development. .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.9
- DOI:
- 10.4238/2012.August.31.9
11�²-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease
Authors: F. Atalar B. Vural C. Ciftci A. Demirkan G. Akan B. Susleyici-Duman D. Gunay B. Akpinar E. Sagbas U. Ozbek A.S. Buyukdevrim
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) activity and mRNA levels are increased in visceral and subcutaneous adipose tissues of metabolic syndrome subjects. We analyzed 11β-HSD-1 expression in human epicardial adipose (EA) and ascending aorta (AA) tissues of metabolic syndrome patients and examined their contribution to the devel.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.10
- DOI:
- 10.4238/2012.August.31.10
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer
Authors: T.D. Silva A.V. Felipe C.A.M. Pimenta K. Bar�£o N.M. Forones
We investigated a possible association between alcoholism, cigarette smoking, obesity and CYP2E1 RsaI and 96-bp insertion genetic polymorphisms with risk for colorectal cancer (CRC). Patients with CRC (70 women and 61 men) were matched for gender and age to 206 healthy controls. The mean age of the two groups was 62 years. Meat intake, cigarette smoking a.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.2
- DOI:
- 10.4238/2012.September.3.2
Expression and function of PDGF-�± in columnar epithelial cells of age-related cataracts patients
Authors: J. Wei, H. Tang, Z.Q. Xu, B. Li, L.Q. Xie and G.X. Xu
We studied the expression and function of platelet-derived growth factor A (PDGF-α) in the lens epithelial cells of cataracts patients. Ninety age-related cataracts patients were recruited in our hospital between January 2012 and January 2014. The expression levels of platelet-derived growth factor receptor (PDGFR) in the anterior capsule of the len.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.28
- DOI:
- 10.4238/2015.October.26.28
Cloning and prokaryotic expression of rat homolog of Serpina3n and its expression change during liver regeneration
Authors: G.P. Wang X.S. Zhang Y.H. Li J.L. Zheng C.Z. Tang W.X. Zhang
A strikingly upregulated expressed sequence tag was screened from regenerating rat liver at 8 h in a 0-4-8-12 h short-interval successive partial hepatectomy model from a previous study. In the present study, a full-length open reading frame (ORF) corresponding to this expressed sequence tag was predicted through electronic cloning and was subsequently cl.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.6
- DOI:
- 10.4238/2012.September.3.6
Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men
Authors: Y. Huang, H.D. Ye, X. Gao, S. Nie, Q.X. Hong, H.H. Ji, J. Sun, S.J. Zhou, B. Fei, K.Q. Li, J.K. Zhao, Z.P. Wang, M.Q. Xu and S.W. Duan
Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution o.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.3
- DOI:
- 10.4238/2015.October.28.3
Selection pressures have driven population differentiation of domesticated and wild common carp (Cyprinus carpio L.)
Authors: L.H. Xu C.H. Wang J. Wang Z.J. Dong Y.Q. Ma X.X. Yang
Selection pressures are the principle evolutionary forces for the genetic differentiation of populations. Recent changes in selection pressures on mitochondrial DNA and microsatellite have been described in a wide variety of organisms. The common carp (Cyprinus carpio) has experienced strong selection pressure, in particular artificial selection, during i.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.12.5
- DOI:
- 10.4238/2012.September.12.5