Human Genetics
IL-8 -251A/T polymorphism contributes to coronary artery disease susceptibility in a Chinese population
Authors: R.J. Zhang, X.D. Li, S.W. Zhang, X.H. Li and L. Wu
Interleukin-8 (IL-8) is a mediator of inflammation and plays an important role in regulating immune responses. To date, several studies have tested the association between IL-8 gene polymorphisms and development of coronary artery disease (CAD), but their results have proved to be inconsistent. We conducted an investigation to.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018224
- DOI:
- 10.4238/gmr16018224
Polymorphism in the third intron of the interferon-�³ gene is associated with susceptibility to multiple sclerosis
Authors: X.L. Wang, F.R. Meng, X. Wang, S.H. Wang and L. Guo
The present study aims to examine the relationship between polymorphisms in the third intron of the IFN-γ gene and their influence on susceptibility to multiple sclerosis. A population-based case-control study was used for this purpose. Multiple sclerosis patients and healthy controls were interviewed. Genetic polymorphi.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16017538
- DOI:
- 10.4238/gmr16017538
Osteoblast differentiation of rabbit adipose-derived stem cells by polyethylenimine-mediated BMP-2 gene transfection in vitro
Authors: Q.F. Wang, Y. Huang, G.C. He, H.S. Wang, Z.H. Chen, X.H. Cai, Y.H. Xie and Q. Liu
The aim of this study was to examine the efficiency of polyethylenimine-mediated transfection of the human bone morphogenetic protein-2 (BMP-2) gene into rabbit adipose-derived stem cells (ADSCs), and its effect on osteoblast differentiation. Adipose tissue was isolated from the necks of adult Japanese white rabbits and cultur.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16015358
- DOI:
- 10.4238/gmr16015358
Reduced levels of genetic variation in Aedes albopictus (Diptera: Culicidae) from Manaus, Amazonas State, Brazil, based on analysis of the mitochondrial DNA ND5 gene
Authors: R.T. Maia1, V.M. Scarpassa2, L.H. Maciel-Litaiff3 and W.P. Tadei2
Aedes albopictus, a mosquito originally from Southeast Asia, is considered to be one of the main vectors of dengue fever, yellow fever and other arboviruses. We examined the genetic variability and population structure of 68 individuals of Ae. albopictus collected from five neighborhoods of the city of Manaus, based on the mitochondrial gene cod.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr624
- DOI:
- 10.4238/vol8-3gmr624
Genetic characterization of the mite Varroa destructor (Acari: Varroidae) collected from honey bees Apis mellifera (Hymenoptera, Apidae) in the State of Santa Catarina, Brazil
Authors: R. Strapazzon, F.E. Carneiro, J.C.V. Guerra Jr. and G. Moretto
The mite Varroa destructor is an ectoparasite that is considered a major pest for beekeeping with European honey bees. However, Africanized bee colonies are less threatened by this ectoparasite, because infestation levels remain low in these bees. The low reproductive ability of female mites of the Japanese biotype (J), introduced to Brazil early in .. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr567
- DOI:
- 10.4238/vol8-3gmr567
Molecular cloning, sequence characterization of a novel pepper gene NADP-ICDH and its effect on cytoplasmic male sterility
Authors: M.H. Deng J.F. Wen J.L. Huo H.S. Zhu X.Z. Dai Z.Q. Zhang H. Zhou X.X. Zou
NADP-dependent isocitrate dehydrogenase (NADP-ICDH) is an important enzyme involved in energy metabolism. The complete coding sequence of the pepper (Capsicum annuum) NADP-ICDH gene was amplified using a reverse transcriptase PCR based on the conserved sequence information of the tomato and other Solanaceae plants and known highly homologous pepper ESTs. Nuc.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.15
- DOI:
- 10.4238/2012.May.18.15
Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors
Authors: A.-X. Wang B. Xu N. Tong S.-Q. Chen Y. Yang X.-W. Zhang H. Jiang N. Liu J. Liu X.-N. Hu G.-Z. Sha M. Chen
Evidence has shown that miR-146a is involved in carcinogenesis, and a common G/C variant (rs2910164) in the pre-miR-146a gene has been associated with various types of cancer. We summarized the data from 22 published case-control studies on the association between rs2910164 and cancer risk and performed subgroup analyses by ethnicity, gender and smoking stat.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.2
- DOI:
- 10.4238/2012.August.31.2
Association between C807T(C/T) polymorphism of platelet glycoprotein gene and sensitivity to ischemic stroke: a meta-analysis
Authors: C. Luo, L.H. Fan, H. Zhang, J. Zhao, L. Li, L. Zhang, H.X. Zhang and M.M. Ma
Ischemic stroke can lead to loss of neurologic functions. It occurs due to obstruction in blood supply to the brain. It has been proposed that C807T(C/T) polymorphism within the platelet glycoprotein gene may be associated with density and function of glycoprotein Ia/IIa receptors and contributes to the pathogenesis of thrombo.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019416
- DOI:
- 10.4238/gmr16019416
Expression of growth genes in response to glycerol use in Japanese quail diets
Authors: E. Gasparino A.R. Oliveira Neto A.P. Del Vesco A.V. Pires E. Batista D.M. Voltolini K.R.S. Souza
Glycerol can be used as a substitute for corn for feeding poultry, but there are concerns about how it may affect growth performance and health of the birds. We evaluated the expression of mRNA of growth hormone (GH) and insulin-like growth factor I (IGF-I) in 35-day-old Japanese quails fed different glycerol levels (0, 4, and 8% dietary glycerol instead .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.3
- DOI:
- 10.4238/2012.August.31.3
Role of Th1/Th2 cytokines in the diagnosis and prognostic evaluation of ankylosing spondylitis
Authors: J.T. Wen, D.H. Zhang, P.F. Fang, M.H. Li, R.J. Wang, S.H. Li
Ankylosing spondylitis (AS), a progressive disease of the spine, manifests as peripheral arthritis with tendon and ligament inflammation that restricts activity. AS is a rheumatoid autoimmune disease although the rheumatoid factor is absent in patients with AS. It is characterized by inflammatory changes such as elevated level.. Read More»
- Genet. Mol. Res. 16(1):
- Ankylosing spondylitis; Th1; Th2; Inflammatory cytokines
- DOI:
- Ankylosing spondylitis; Th1; Th2; Inflammatory cytokines