Human Genetics
Assessing potential miRNA targets based on a Markov model
Authors: Hao-Yue Fu1,2, Ding-Yu Xue2, Xiang-de Zhang1 and Pei-Ying Yang2
At present, studies on microRNA mainly focus on the identification of microRNA genes and their mRNA targets. Although researchers have identified many microRNA genes, relatively few microRNA targets have been identified by experimental methods. Computational programs designed for predicting potential microRNA targets provide numerous targets for expe.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr604
- DOI:
- 10.4238/vol8-3gmr604
Occurrence of multiple nucleolus organizer regions and intraspecific karyotype variation in Scaptotrigona xanthotricha Moure (Hymenoptera, Meliponini)
Authors: O.M.P. Duarte1, C.C.C. Martins1, A.M. Waldschmidt2 and M.A. Costa1
Scaptotrigona xanthotricha has a wide geographic distribution in the Brazilian Atlantic rainforest. One population from southeast and two from northeast Brazil were analyzed and were found to have chromosome polymorphisms. Although the chromosome number 2n = 34 is conserved in this species, karyotypic analysis revealed clear differences between .. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr598
- DOI:
- 10.4238/vol8-3gmr598
A novel NF1 mutation in a Chinese patient with giant caf�©-au-lait macule in neurofibromatosis type 1 associated with a malignant peripheral nerve sheath tumor and bone abnormality
Authors: H.-X. Tong M. Li Y. Zhang J. Zhu W.-Q. Lu
Neurofibromatosis type 1 (NF1; OMIM#162200) is a common neurocutaneous disorder that is characterized by multiple café-au-lait, skinfold freckling, Lisch nodules, and neurofibromas. Mutations in the NF1 gene, which encodes the neurofibromin protein, have been identified as the pathogenic gene of NF1. In this study, we present a clinical and molecul.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.10.6
- DOI:
- 10.4238/2012.July.10.6
Generation of a preliminary bovine gene atlas, using expression clustering to annotate gene function
Authors: O.M. Keane1,3, N. Maqbool2, A.F. McCulloch2, J.C. McEwan2 and K.G. Dodds2
Genes whose products function in a common biological process are often co-regulated. When regulation occurs at the transcriptional level, co-expressed genes can be detected globally by expression arrays or by sequencing non-normalized cDNA libraries. We examined bovine gene expression in 27 tissues using non-normalized cDNA library sequencing. Contigs wer.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr594
- DOI:
- 10.4238/vol8-3gmr594
Gene expressions levels of 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPase�² in gill tissue of Mugil cephalus acclimated to low salinity
Authors: L. Li, M. Jiang and X.Q. Shen
Fishes adapt to salinity changes primarily through osmotic pressure regulation, a process often associated with several genes, including 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPaseβ. The present study investigated the differential expression of genes 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPaseβ in the gill tissue of Mu.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019444
- DOI:
- 10.4238/gmr16019444
Inhibition of SHH pathway mechanisms by arsenic trioxide in pediatric medulloblastomas: a comprehensive literature review
Authors: P.H.S. Klinger, A.F. Andrade, L.E.A. Delsin, R.G.P. Queiroz, C.A. Scrideli, L.G. Tone and E.T. Valera
Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. Among the four different medulloblastoma subgroups described to date, the sonic hedgehog (SHH) genetic pathway is the pathway activated in the tumorigene.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019412
- DOI:
- 10.4238/gmr16019412
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes
Authors: J. Zekri, A. Al-Shehri, M. Mahrous, S. Al-Rehaily, T. Darwish, S. Bassi, H. El Taani, A. Al Zahrani, S. Elsamany, J. Al-Maghrabi and B.B. Sadiq
Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019369
- DOI:
- 10.4238/gmr16019369
Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer
Authors: D.H. Xiu, Y. Chen, L. Liu, H.S. Yang and G.F. Liu
Kruppel-like factors (KLFs) are a group of transcriptional regulators that have recently been identified to exhibit tumor-suppressive function against various gastrointestinal cancers. The present study aims to investigate the expression patterns and prognostic value of KLF-4 in colorectal cancers (CRCs). KLF-4 levels in CRC t.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019272
- DOI:
- 10.4238/gmr16019272
Arylamine N-acetyltransferase 2 genotypes in a Mexican population
Authors: L. Taja-Chayeb, J.A. Ag�ºndez, C. Miguez-Mu�±oz, A. Chavez-Blanco and A. Due�±as-Gonzalez
The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican popu.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.7
- DOI:
- 10.4238/2012.April.27.7
MicroRNA-139 modulates Alzheimer�s-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2
Authors: Y. Tang, J.S. Bao, J.H. Su and W. Huang
Alzheimer’s disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as we.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019166
- DOI:
- 10.4238/gmr16019166