Human Genetics
Protective effects of naringin against gp120-induced injury mediated by P2X7 receptors in BV2 microglial cells
Authors: Q. Chen, J. Hu, S.S. Qin, C.L. Liu, H. Wu, J.R. Wang, X.M. Lu, J. Wang, G.Q. Chen, Y. Liu, B.Y. Liu, C.S. Xu and S.D. Liang
This study was aimed at exploring the effects of P2X7 receptors on gp120-induced injury and naringin’s protective effects against gp120-induced injury in BV2 microglia. BV2 microglia injury model was established by gp120 treatment and MTS assay was used to verify whether naringin has a cell-protective effect against gp12.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028649
- DOI:
- 10.4238/gmr.15028649
Analysis of DNA equilibrium configuration under interfacial traction
Authors: Y.Z. Wang, Q.C. Zhang, W. Wang and Y.W. Yang
Kirchhoff thin elastic rod models are important in the study of the mechanism determining the configurations of flexible structures not only at the macroscopic but also at the microscopic scale. In this study, the energy balance method has been well applied to analyze the configuration of a DNA elastic rod in the presence of i.. Read More»
- Genet. Mol. Res. 15(2):
Identification of robust adaptation gene regulatory network parameters using an improved particle swarm optimization algorithm
Authors: X.N. Huang and H.P. Ren
Robust adaptation is a critical ability of gene regulatory network (GRN) to survive in a fluctuating environment, which represents the system responding to an input stimulus rapidly and then returning to its pre-stimulus steady state timely. In this paper, the GRN is modeled using the Michaelis-Menten rate equations, which are.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028652
- DOI:
- 10.4238/gmr.15028652
Verification and characterization of chromosome duplication in haploid maize
Authors: E.G. de Oliveira Couto, E.V. Resende Von Pinho, R.G. Von Pinho, A.D. Veiga, M.R. de Carvalho, F. de Oliveira Bustamante and M.S. Nascimento
Doubled haploid technology has been used by various private companies. However, information regarding chromosome duplication methodologies, particularly those concerning techniques used to identify duplication in cells, is limited. Thus, we analyzed and characterized artificially doubled haploids using microsatellites molecular markers, pollen viability, .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.9
- DOI:
- 10.4238/2015.June.26.9
Construction of a cDNA library of the Chinese wild Vitis amurensis under cold stress and analysis of potential hardiness-related expressed sequence tags
Authors: J. Zhang, N. Liu, R. Niu, Y. Liu, H. Zhai, W. Xu and Y. Wang
A cDNA library of Chinese wild Vitis amurensis, which is the most cold-resistant species in the genus Vitis, was constructed using young leaves of seedlings of the clone Heilongjiang potted and subjected to cold stress. The leaves were harvested at various times after cold stress for total RNA extraction, which was used to generate expressed sequence tags.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.12.5
- DOI:
- 10.4238/2013.April.12.5
Polymorphism in the melatonin receptor gene in buffalo populations of the Brazilian Amazon - Genet. Mol. Res. 15 (2): gmr.15027960
Authors: E.M. Barbosa, B.B. Souza, R.C. Guimar�£es, J.S.N. Azevedo, E.C. Gon�§alves, H.F.L. Ribeiro, S.T. Rolim Filho and E. Silva Filho
-.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.150279601
- DOI:
- 10.4238/gmr.150279601
Identification of Ca2+-binding residues of a protein from its primary sequence
Authors: Z. Jiang, X.Z. Hu, G. Geriletu, H.R. Xing and X.Y. Cao
Calcium is one of the most abundant minerals in the human body, playing a critical role in many cellular activities by interacting with different calcium ion (Ca2+)-binding proteins. Therefore, the correct identification of Ca2+-binding residues is essential for protein functional research. In this study, a new method was deve.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027618
- DOI:
- 10.4238/gmr.15027618
Phylogenetic relationships of twenty Gymnothorax species based on cytochrome b sequence data
Authors: M. Du, S.W. Yin and B.Z. Niu
To study the phylogenetic relationships of the genus Gymnothorax (moray eels) distributed in South China Sea, polymerase chain reactions were performed, and the amplification products were sequenced by cloning into the PMD18T-vector (TaKaRa). The entire gene sequences encoding cytochrome b (1140 bp) for 16 Gymnothorax (G. flav.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028157
- DOI:
- 10.4238/gmr.15028157
S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer
Authors: Z. Hussain, M.I. Khan, M. Shahid and F.N. Almajhdi
DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in cancer development. Gene silencing via CpG island methylation/demethylation in the promoter region is one of the mechanisms by which different genes are inactivated/activated in human cancers. Tissue inhibitor of metalloprotein.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.10.6
- DOI:
- 10.4238/2013.April.10.6
Analysis of uridine diphosphate glucuronosyl transferase 1A1 gene mutations in neonates with unconjugated hyperbilirubinemia
Authors: X.H. Guo, Y.F. Sun, M. Cui1, J.B. Wang, S.Z. Han and J. Miao
This study was carried out to analyze uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) gene mutations in neonates with unconjugated hyperbilirubinemia, from two different ethnic groups. Polymerase chain reaction and gene sequencing were used to analyze the differences in genotypes and allele frequencies of differ.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028373
- DOI:
- 10.4238/gmr.15028373