Human Genetics
Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population
Authors: F.M. Feng, X.X. Liu, Y.H. Sun, P. Zhang, S.F. Sun, B. Zhang, X.T. Wang and L.J. Lu
We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using pol.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.14
- DOI:
- 10.4238/2014.September.26.14
Comparative analysis of the liver tissue transcriptomes of Mongolian and Lanzhou fat-tailed sheep
Authors: X. Cheng, S.G. Zhao, Y. Yue, Z. Liu, H.W. Li and J.P. Wu
Research on gene regulation has been made possible with the help of RNA sequencing applications such as RNA-Seq technology for high-throughput sequencing platforms. Recent studies have explored the transcriptomes from different tissues of domestic animals using RNA-Seq technology, but little research has been done to study the.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028572
- DOI:
- 10.4238/gmr.15028572
Value of diffusion weighted imaging in the differential diagnosis of benign and malignant breast lesions at 3.0T MRI
Authors: X.Y. Jiang, Q.Z. Xie, X.S. Cao, T. Gao, C.Y. Xing and X.L. Li
The aim of this study was to investigate the correlation between apparent diffusion coefficients (ADCs), the relative apparent diffusion coefficient (rADC), and the pathological prognostic factor human epidermal growth factor receptor 2 (HER-2) in patients with breast cancer. A total of 64 women with breast cancer underwent br.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.15
- DOI:
- 10.4238/2014.September.26.15
Association of vitamin D receptor BsmI gene polymorphism with risk of low bone mineral density in post-menopausal women: a meta-analysis
Authors: C. Ma, Q.L. Zhou, Y.J. Deng, X. Liang, D.P. Wu and Y.Z. Dong
The vitamin D receptor BsmI gene polymorphism is reportedly associated with low bone mineral density (BMD) in postmenopausal women, but results from previous studies are conflicting. In the present study, we investigated the association between this polymorphism and the risk of low BMD through a meta-analysis of published stud.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.17
- DOI:
- 10.4238/2014.September.26.17
Overregulation of microRNA-212 in the poor prognosis of esophageal cancer patients
Authors: B. Qi, S.G. Liu, X.G. Qin, W.J. Yao, J.G. Lu, L. Guo, T.Y. Wang, H.C. Li and B.S. Zhao
There have been few reports evaluating the expression and function of the microRNA miR-212 in esophageal cancer. The aim of this study was to investigate the relationship between miR-212 expression and clinicopathological factors and prognoses of esophageal cancer. MicroRNA was extracted from 46 esophageal cancer patients usin.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.18
- DOI:
- 10.4238/2014.September.26.18
Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction
Authors: B. Yuan and J.F. Teng
We examined the association between the adiponectin receptor 2 gene and the risk of ischemic stroke. Polymerase chain reaction-restriction fragment length polymorphism was used to detect rs12342 genotypes of the adiponectin receptor 2 gene in 300 ischemic stroke patients and 320 age- and gender-matched healthy controls. In the.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.19
- DOI:
- 10.4238/2014.September.26.19
Relationship between genetic polymorphisms of DNA ligase 1 and non-small cell lung cancer susceptibility and radiosensitivity
Authors: H. Tian, X. He, L. Yin, W.J. Guo, Y.Y. Xia and Z.X. Jiang
The aim of this study was to examine the relationship between genetic polymorphisms in DNA ligase 1 (LIG1) and nonsmall cell lung cancer (NSCLC) susceptibility and radiosensitivity in a Chinese population. This was a case-control study that included 352 NSCLC patients and 448 healthy controls. Polymerase chain reactionrestriction fragment length polymorph.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.14
- DOI:
- 10.4238/2015.June.26.14
miR-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2
Authors: P. Wang, H.Y. Lv, D.M. Zhou and E.N. Zhang
Aberrant expression of microRNA is associated with the development and progression of cancers. MicroRNA-204 (miR-204) down-regulation has been previously demonstrated in non-small-cell lung carcinoma (NSCLC); however, the underlying mechanism by which miR-204 suppresses tumorigenesis in NSCLC remains elusive. In this study, mi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026415
- DOI:
- 10.4238/gmr.15026415
Estimate of genetic gain in popcorn after cycles of phenotypic recurrent selection
Authors: H.J. Ematn�©, J.A.R. Nunes, K.O.G. Dias, P.E.R. Prado and J.C. Souza
Popcorn is widely consumed in Brazil, yet there are few breeding programs for this crop. Recurrent selection (RS) is a viable breeding alternative for popcorn; however, the gains achieved must be frequently checked. The aim of this study was to assess the effect of selection for grain type (round and pointed) after four cycles.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026860
- DOI:
- 10.4238/gmr.15026860
Tristetraprolin: a novel mediator of the anticancer properties of resveratrol
Authors: C. Li, C. Tang and G. He
Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). The initiation and progression of cancer are associa.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027213
- DOI:
- 10.4238/gmr.15027213