Human Genetics
Association between MTHFR 677C/T polymorphism and psoriasis risk:a meta-analysis
Authors: J.H. Qi,J.H. Qi,N. Shi,Y.J. Chen and G. Nie
Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.16
Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis
Authors: S.Y. Pang, H.Y. Liu, Y.J. Huang, Y.F. Liu, Y.M. Dai, P. Zeng and H.S. Zeng
The prevalence rates of anti-citrullinated protein/peptide antibodies (ACPAs) were investigated in a cohort of juvenile idiopathic arthritis (JIA) patients, and their diagnostic performances were compared. ACPAs, including anti-cyclic citrullinated peptide IgG (anti-CCP), anti-CCP IgG/IgA (anti-CCP3.1), citrullinated recombina.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028641
- DOI:
- 10.4238/gmr.15028641
Inhibitory effect of ursolic acid and oleanolic acid from Eriobotrya fragrans on A549 cell viability in vivo
Authors: Y.S. Gao, Y. Yuan, G. Song and S.Q. Lin
Loquat [Eriobotrya japonica (Lindl.)] is a traditional Chinese medicine, which has been used as an anti-inflammatory and for curing chronic bronchitis among other potential applications. Extracted ursolic acid (UA) and oleanolic acid (OA) from wild loquat were previously found capable of suppressing the proliferation of A549 c.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028642
- DOI:
- 10.4238/gmr.15028642
Models of logistic regression analysis, support vector machine, and back-propagation neural network based on serum tumor markers in colorectal cancer diagnosis
Authors: B. Zhang, X.L. Liang, H.Y. Gao, L.S. Ye and Y.G. Wang
We evaluated the application of three machine learning algorithms, including logistic regression, support vector machine and back-propagation neural network, for diagnosing congenital heart disease and colorectal cancer. By inspecting related serum tumor marker levels in colorectal cancer patients and healthy subjects, early d.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028643
- DOI:
- 10.4238/gmr.15028643
PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer
Authors: F.S. Ramos, L.T.R. Serino, C.M.S. Carvalho, R.S. Lima, C.A. Urban, I.J. Cavalli and E.M.S.F. Ribeiro
Changes in the expression of the protein disulfide isomerase genes PDIA3 and PDIA6 may increase endoplasmic reticulum stress, leading to cellular instability and neoplasia. We evaluated the expression of PDIA3 and PDIA6 in invasive ductal carcinomas. Using reverse transcription-quantitative polymerase chain reaction, we compared the mRNA expression level .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.4
- DOI:
- 10.4238/2015.June.26.4
Inhibition of adipogenic differentiation of bone marrow mesenchymal stem cells by erythropoietin via activating ERK and P38 MAPK
Authors: G.X. Liu, J.C. Zhu, X.Y. Chen, A.Z. Zhu, C.C. Liu, Q. Lai and S.T. Chen
We examined whether erythropoietin (EPO) can inhibit adipogenic differentiation of mesenchymal stem cells (MSCs) in the mouse bone marrow and its underlying mechanism. We separated and extracted mouse bone marrow MSCs and induced adipogenic differentiation using 3-isobutyl-1-methylxanthine, insulin, and dexamethasone. Different concentrations of EPO were .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.5
- DOI:
- 10.4238/2015.June.26.5
Serum immunoglobulin E level and its impact on the pregnancy outcome associated with fetal growth restriction: a prospective cohort study
Authors: F. Xiong,Y. Tong,P. Li,T. Huo and M. Mao
We evaluated the relationship between total serum immunoglobulin E (IgE) levels and pregnancy outcome in a prospective cohort study focusing on fetal growth restriction (FGR). Sixty women with FGR and twenty with normal singleton pregnancy were enrolled during their third trimester. Infants were followed up for 6 months. Blood samples were obtained from p.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.2
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.2
Analysis of regulatory mechanism after ErbB4 gene mutation based on local modeling methodology
Authors: C.L. Chen and J.W. Zhao
ErbB4 is an oncogene belonging to the epidermal growth factor receptor family and contributes to the occurrence and development of multiple cancers, such as gastric, breast, and colorectal cancers. Therefore, studies of the regulation of ErbB4 in cancerigenic pathway will advance molecular targeted therapy. Advanced bioinforma.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028647
- DOI:
- 10.4238/gmr.15028647
Expression of human amyloid precursor protein in Drosophila melanogaster nerve cells causes a decrease in presynaptic gene mRNA levels
Authors: D.I. Rodin, A.L. Schwarzman and S.V. Sarantseva
Amyloid precursor protein (APP) is a key player in Alzheimer’s disease. The proteolytic cleavage of APP results in various short peptide fragments including the toxic amyloid-beta peptide, which is a main component of senile plaques. However, the functions of APP and its processed fragments are not yet well understood. Here, using real-time polymera.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.2
- DOI:
- 10.4238/2015.August.10.2
Correlation between protein 4.1R and the progression of heart failure in vivo
Authors: Z. Wei, G. Yang, R. Xu, C. Zhu, F. He, Q. Dou and J. Tang
We aimed to assess the protein 4.1R (4.1R) expression of the membrane skeleton in cardiomyocytes and to determine the potential role of 4.1R in the pathogenesis of heart failure (HF). Forty-two male mice were randomly divided into two groups: an HF group (N = 22) and control group (N = 20). The HF model was established by abdo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028648
- DOI:
- 10.4238/gmr.15028648